← All supplements

Zinc carnosine

Supplement mineral complex gut
Aka: PepZin GI, polaprezinc, zinc-L-carnosine
Brands seen in Singapore: California Gold Nutrition, Doctor's Best, Terra Origin, NOW Foods, Life Extension
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Gastric mucosal protection — small, mixed human evidence
When to take
Twice daily in the h. pylori trial, with the antibiotics
Take with
Water · absorption was measured fasted and after food
Pros & cons
Pros
  • H. pylori clearance 93.5% vs 69.6% when added on
  • Granules were well tolerated in healthy-adult pk work
  • An infant reflux RCT found it safe and non-inferior
Cons
  • Efsa 2026: safety and bioavailability not established
  • The h. pylori result is one 92-patient trial
  • The zinc it carries counts toward HSA's 15 mg limit
Sources
  1. EFSA NDA Panel — Safety of zinc l-carnosine as a novel food and bioavailability of zinc from this source (EFSA Journal 2026) · read 2026-08-27
    what it says
    “The target population is individuals above the age of 12 years, excluding pregnant and lactating women … The Panel concludes that the NF is insufficiently characterised and neither its bioavailability nor its safety can be established”
  2. Zinc carnosine-based modified bismuth quadruple therapy vs standard triple therapy for Helicobacter pylori eradication: a randomized controlled study (World J Clin Cases 2022; n=92) · read 2026-08-27
    what it says
    “a 10-d course of modified bismuth quadruple therapy fortified with zinc carnosine … zinc carnosine (75 mg twice daily). … The eradication rate was higher [93.5% (43/46)] … compared to 69.6% (32/46) in the standard TT group”
  3. Pharmacokinetics and Safety of Polaprezinc Granules Oral Administration in Healthy Chinese Volunteers Under Fasting and Fed Conditions (Clin Transl Sci 2025; n=48) · read 2026-08-27
    what it says
    “Healthy Chinese fasting (N = 24, 75 mg) or fed (N = 24, 300 mg) subjects randomly received a single oral dose … Both study products were well-tolerated with no serious adverse events”
  4. Zinc-L-Carnosine (Polaprezinc) in managing infant regurgitation: a two-center randomized controlled trial (Front Pediatr 2026; n=60) · read 2026-08-27
    what it says
    “Zinc-L-carnosine is a safe and effective alternative to thickened formula in treating persistent infant regurgitation … Although no statistically significant difference was observed in overall symptomatic remission”
  5. Pharmacological Treatment of Gastritis: A Narrative Review with a Systematic Literature Search (Gut Liver 2025) — mucoprotective agents · read 2026-08-27
    what it says
    “Mucoprotective agents enhance gastric mucosal protection through multiple mechanisms, such as by promoting mucosal regeneration, reducing inflammation, and mitigating oxidative stress”
  6. NIH ODS — Zinc Fact Sheet for Health Professionals — Recommended Intakes; Dietary Supplements (FDA Daily Value) · read 2026-08-27
    what it says
    “These values range from 8 to 12 mg for adults … The DV for zinc is 11 mg for adults and children age 4 years and older”
  7. NIH ODS — Zinc Fact Sheet for Health Professionals — Health Risks from Excessive Zinc · read 2026-08-27
    what it says
    “Doses of 50 mg of zinc or more over a period of weeks can inhibit copper absorption, reduce immune function, and lower high-density lipoprotein cholesterol levels … The Tolerable Upper Intake Level for zinc is 40 mg for adults”
  8. NIH ODS — Zinc Fact Sheet for Health Professionals — Zinc and Health / Dietary Supplements (iron interaction) · read 2026-08-27
    what it says
    “Taking supplements containing 25 mg elemental iron or more at the same time as zinc supplements can reduce zinc absorption and plasma zinc concentrations”
  9. HSA — Guidelines on Prohibited and Restricted Ingredients in HS and TM (October 2025), Annex A row 118: Zinc · read 2026-08-27
    what it says
    “118. Zinc — Restricted use in HS and TM — Maximum Daily Dose: When for oral use by general adult population, the maximum recommended daily dose should not provide more than 15mg”
  10. HSA — Health Supplements Guidelines (January 2026), Table 5 Minerals Limits + clause 4.11 · read 2026-08-27
    what it says
    “Table 5: Minerals Limits … Zinc 15 mg … Examples of supplements intended for specific adult population groups that require higher levels of supplementation are: a. Zinc for patients with wounds or metabolic conditions”
  11. iHerb Singapore — Zinc Carnosine · read 2026-08-27
    what it says
    “1 - 26 of 26 results; California Gold Nutrition, Zinc-L-Carnosine Complex; Doctor's Best, PepZin GI®, Zinc-L-Carnosine; Terra Origin, Healthy Gut™; NOW Foods, Gastro Comfort™ with PepZin GI™; Life Extension, Gastro-Ease™, 60 Vegetarian Capsules”
Report a correction View as JSON

Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.