{"ok":true,"entry":{"slug":"zinc-carnosine","kind":"supplement","name":"zinc carnosine","aliases":["PepZin GI","polaprezinc","zinc-L-carnosine"],"brands_sg":["California Gold Nutrition","Doctor's Best","Terra Origin","NOW Foods","Life Extension"],"class":"mineral complex","tags":["gut"],"use_for":"gastric mucosal protection — small, mixed human evidence","use_after":"twice daily in the h. pylori trial, with the antibiotics","use_duration":null,"take_with":"water · absorption was measured fasted and after food","pros":["h. pylori clearance 93.5% vs 69.6% when added on","granules were well tolerated in healthy-adult pk work","an infant reflux rct found it safe and non-inferior"],"cons":["efsa 2026: safety and bioavailability not established","the h. pylori result is one 92-patient trial","the zinc it carries counts toward hsa's 15 mg limit"],"dose_note":"the h. pylori trial added zinc carnosine 75 mg twice daily to triple therapy plus bismuth for 10 days; pharmacokinetic work used single doses of 75 mg fasting and 300 mg fed in healthy adults; no rda, ul or fda dv exists for the complex itself, and efsa concluded in 2026 that it is insufficiently characterised; the elemental zinc it provides counts toward the zinc rda (11 mg men, 8 mg women), the 40 mg ul, the 11 mg fda dv and hsa's 15 mg maximum daily dose","dosage":{"ul":40,"unit":"mg elemental zinc","fda_dv":11,"rda_ai":null,"ul_status":"established","population":"general adult","hsa_max_daily":15},"ul_status":"established","sg_class":null,"cautions":["efsa could not establish the complex's safety — ask your doctor before starting","over 40 mg elemental zinc a day — above the ul; only under a doctor's care","50 mg zinc or more for weeks — copper absorption and hdl fall","pregnant or breastfeeding, or under 12 — outside the efsa target population"],"clashes":[{"src":["nih_ods_zinc_supp"],"note":"taken together, zinc absorption and plasma zinc fall","with":"iron supplements (25 mg or more)"},{"src":["nih_ods_zinc_ul"],"note":"50 mg+ zinc for weeks inhibits copper absorption","with":"copper"}],"sources":[{"id":"efsa_znc2026","url":"https://europepmc.org/article/PMC/PMC13273396","label":"EFSA NDA Panel — Safety of zinc l-carnosine as a novel food and bioavailability of zinc from this source (EFSA Journal 2026)","quote":"The target population is individuals above the age of 12 years, excluding pregnant and lactating women … The Panel concludes that the NF is insufficiently characterised and neither its bioavailability nor its safety can be established","accessed":"2026-08-27"},{"id":"hp_zncarn2022","url":"https://europepmc.org/article/PMC/PMC8727261","label":"Zinc carnosine-based modified bismuth quadruple therapy vs standard triple therapy for Helicobacter pylori eradication: a randomized controlled study (World J Clin Cases 2022; n=92)","quote":"a 10-d course of modified bismuth quadruple therapy fortified with zinc carnosine … zinc carnosine (75 mg twice daily). … The eradication rate was higher [93.5% (43/46)] … compared to 69.6% (32/46) in the standard TT group","accessed":"2026-08-27"},{"id":"pola_pk2025","url":"https://europepmc.org/article/PMC/PMC12261970","label":"Pharmacokinetics and Safety of Polaprezinc Granules Oral Administration in Healthy Chinese Volunteers Under Fasting and Fed Conditions (Clin Transl Sci 2025; n=48)","quote":"Healthy Chinese fasting (N = 24, 75 mg) or fed (N = 24, 300 mg) subjects randomly received a single oral dose … Both study products were well-tolerated with no serious adverse events","accessed":"2026-08-27"},{"id":"znc_infant2026","url":"https://europepmc.org/article/PMC/PMC13139114","label":"Zinc-L-Carnosine (Polaprezinc) in managing infant regurgitation: a two-center randomized controlled trial (Front Pediatr 2026; n=60)","quote":"Zinc-L-carnosine is a safe and effective alternative to thickened formula in treating persistent infant regurgitation … Although no statistically significant difference was observed in overall symptomatic remission","accessed":"2026-08-27"},{"id":"gastritis_review2025","url":"https://europepmc.org/article/PMC/PMC12616137","label":"Pharmacological Treatment of Gastritis: A Narrative Review with a Systematic Literature Search (Gut Liver 2025) — mucoprotective agents","quote":"Mucoprotective agents enhance gastric mucosal protection through multiple mechanisms, such as by promoting mucosal regeneration, reducing inflammation, and mitigating oxidative stress","accessed":"2026-08-27"},{"id":"nih_ods_zinc_rda","url":"https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/","label":"NIH ODS — Zinc Fact Sheet for Health Professionals — Recommended Intakes; Dietary Supplements (FDA Daily Value)","quote":"These values range from 8 to 12 mg for adults … The DV for zinc is 11 mg for adults and children age 4 years and older","accessed":"2026-08-27"},{"id":"nih_ods_zinc_ul","url":"https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/","label":"NIH ODS — Zinc Fact Sheet for Health Professionals — Health Risks from Excessive Zinc","quote":"Doses of 50 mg of zinc or more over a period of weeks can inhibit copper absorption, reduce immune function, and lower high-density lipoprotein cholesterol levels … The Tolerable Upper Intake Level for zinc is 40 mg for adults","accessed":"2026-08-27"},{"id":"nih_ods_zinc_supp","url":"https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/","label":"NIH ODS — Zinc Fact Sheet for Health Professionals — Zinc and Health / Dietary Supplements (iron interaction)","quote":"Taking supplements containing 25 mg elemental iron or more at the same time as zinc supplements can reduce zinc absorption and plasma zinc concentrations","accessed":"2026-08-27"},{"id":"hsa_pr_zinc","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in HS and TM (October 2025), Annex A row 118: Zinc","quote":"118. Zinc — Restricted use in HS and TM — Maximum Daily Dose: When for oral use by general adult population, the maximum recommended daily dose should not provide more than 15mg","accessed":"2026-08-27"},{"id":"hsa_hs_zinc","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (January 2026), Table 5 Minerals Limits + clause 4.11","quote":"Table 5: Minerals Limits … Zinc 15 mg … Examples of supplements intended for specific adult population groups that require higher levels of supplementation are: a. Zinc for patients with wounds or metabolic conditions","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/zinc-carnosine","label":"iHerb Singapore — Zinc Carnosine","quote":"1 - 26 of 26 results; California Gold Nutrition, Zinc-L-Carnosine Complex; Doctor's Best, PepZin GI®, Zinc-L-Carnosine; Terra Origin, Healthy Gut™; NOW Foods, Gastro Comfort™ with PepZin GI™; Life Extension, Gastro-Ease™, 60 Vegetarian Capsules","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:34.039038+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}