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White willow bark

Supplement botanical bone & jointgeneral nutrition
Aka: Salix alba, salicin
Brands seen in Singapore: Nature's Way, Super Nutrition, Nature's Answer, Solaray, Frontier Co-op
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Arthritis pain — a small effect at very low certainty
Pros & cons
Pros
  • Pooled RCTs show a small pain benefit
Cons
  • Certainty of the evidence is rated very low
  • Salicylate allergy needs careful assessment first
  • Under 16 — the review says it is best avoided
Sources
  1. Willow Bark (Salix spp.) Used for Pain Relief in Arthritis: A Meta-Analysis of Randomized Controlled Trials (Life 2023) — results and discussion · read 2026-08-27
    what it says
    “meta-analysis showed a statistically significant difference in pain controls … quality of evidence: very low … carefully assessed for those with a history of allergy to salicylates … children under the age of 16 were suggested to avoid using willow bark”
  2. Same meta-analysis (Life 2023) — interaction paragraph and Table 2 study characteristics · read 2026-08-27
    what it says
    “Components in willow bark may interact with anticoagulants (increase bleeding tendency), beta-blockers and diuretics (decrease the effect of the drugs), and NSAIDs (increase the risk of stomach bleeding) … a dose of 240 mg salicin/day”
  3. HSA — Guidelines on health supplements (Singapore), maximum daily limits Tables 4–5 · read 2026-08-27
    what it says
    “Table 4: Vitamins Limits … Nutrient Maximum Daily Limit … Table 5: Minerals Limits”
  4. HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annex A/B · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  5. iHerb Singapore — White Willow Bark category page (default best-selling order) · read 2026-08-27
    what it says
    “White Willow Bark”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.