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Vortioxetine

Medication multimodal antidepressant mental health
Aka: Brintellix
Brands seen in Singapore: Brintellix, Vortioson
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
HealthHub: symptoms of depression such as low mood
When to take
HealthHub: with or without food; drops go into a drink
Take with
Water · hh: alcohol can worsen low mood and add sleepiness
Pros & cons
Pros
  • Hh: a multimodal antidepressant for depression
  • Hh: tablet may be taken with or without food
  • HSA: 5, 10 and 20 mg tablets and oral drops in SG
Cons
  • Hh: nausea, diarrhoea, constipation, dizziness
  • Hh: unusual dreams, decreased sexual drive
  • Hh: stopping suddenly brings dizziness, nausea
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally) · read 2026-08-27
    what it says
    “All seven registered vortioxetine products read 'Prescription Only' — BRINTELLIX FILM-COATED TABLETS 5/10/20MG, BRINTELLIX ORAL DROPS, SOLUTION 20MG/ML and VORTIOSON FILM-COATED TABLET 5/10/20MG, ATC N06AX26.”
  2. HealthHub (National Medication Information workgroup, SG) — Vortioxetine: what is this medication for · read 2026-08-27
    what it says
    “Vortioxetine belongs to a class of medications known as Multimodal Serotonergic antidepressants. It is used to treat symptoms of depression such as: Feeling sad, Loss of interest in usual activities, Feeling hopeless or useless”
  3. HealthHub — Vortioxetine: how should I take this medication · read 2026-08-27
    what it says
    “For Vortioxetine tablet: Vortioxetine may be taken with or without food … For Vortioxetine oral drops: … You may mix the oral drops with water, juice or other non-alcoholic drinks … unpleasant effects … if you suddenly stop”
  4. HealthHub — Vortioxetine: what precautions should I take · read 2026-08-27
    what it says
    “Kidney or liver disease … seizures (fits), Parkinson's disease, low sodium in the blood (hyponatremia), increased eye pressure (glaucoma), or bleeding problems … bipolar disorder, abnormally high or excited mood (mania)”
  5. HealthHub — Vortioxetine: common side effects · read 2026-08-27
    what it says
    “Nausea, vomiting or loss of appetite … Diarrhoea … Constipation … Dizziness … Dreams that are different from usual, decreased sexual drive or ability”
  6. HealthHub — Vortioxetine: what food or medication should I avoid · read 2026-08-27
    what it says
    “Avoid drinking alcohol while taking Vortioxetine as it can worsen the symptoms of your depression and cause excessive sleepiness.”
  7. HealthHub — Vortioxetine: important warning for people under 25 · read 2026-08-27
    what it says
    “The following changes have been observed in some patients particularly below the age of 25 years … New or worsening thoughts of harming yourself or ending your life; Worsening agitation, restlessness, violent behaviour”
  8. US FDA label for TRINTELLIX (vortioxetine), section 2.1 Recommended Dosage, via openFDA (Takeda, effective 2025-03-05) · read 2026-08-27
    what it says
    “The recommended starting dose is 10 mg administered orally once daily … Dosage should then be increased to 20 mg/day, as tolerated. The efficacy and safety of doses above 20 mg/day have not been evaluated in controlled clinical trials.”
  9. US FDA label for TRINTELLIX, sections 2.5–2.6 CYP2D6 poor metabolizers, inhibitors and inducers, via openFDA · read 2026-08-27
    what it says
    “The maximum recommended dose of TRINTELLIX is 10 mg/day in known CYP2D6 poor metabolizers. Reduce the dose of TRINTELLIX by one-half when patients are receiving a CYP2D6 strong inhibitor (e.g., bupropion, fluoxetine, paroxetine, or quinidine) concomitantly.”
  10. US FDA label for TRINTELLIX, section 2.4 switching to or from an MAOI, via openFDA · read 2026-08-27
    what it says
    “At least 14 days must elapse between discontinuation of a MAOI intended to treat psychiatric disorders and initiation of therapy with TRINTELLIX … at least 21 days must elapse after stopping TRINTELLIX before starting an MAOI”
  11. US FDA label for TRINTELLIX, section 2.6 use with strong CYP inducers, via openFDA · read 2026-08-27
    what it says
    “Consider increasing the dose of TRINTELLIX when a strong CYP inducer (e.g., rifampin, carbamazepine, or phenytoin) is coadministered for greater than 14 days. The maximum recommended dose should not exceed three times the original dose.”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.