{"ok":true,"entry":{"slug":"vortioxetine","kind":"medication","name":"vortioxetine","aliases":["Brintellix"],"brands_sg":["Brintellix","Vortioson"],"class":"multimodal antidepressant","tags":["mental-health"],"use_for":"healthhub: symptoms of depression such as low mood","use_after":"healthhub: with or without food; drops go into a drink","use_duration":null,"take_with":"water · hh: alcohol can worsen low mood and add sleepiness","pros":["hh: a multimodal antidepressant for depression","hh: tablet may be taken with or without food","hsa: 5, 10 and 20 mg tablets and oral drops in sg"],"cons":["hh: nausea, diarrhoea, constipation, dizziness","hh: unusual dreams, decreased sexual drive","hh: stopping suddenly brings dizziness, nausea"],"dose_note":"the us trintellix label's dosage section gives a starting dose of '10 mg administered orally once daily without regard to meals', increased 'to 20 mg/day, as tolerated', and states that 'the efficacy and safety of doses above 20 mg/day have not been evaluated in controlled clinical trials'. it sets a lower ceiling for some people: 'the maximum recommended dose of trintellix is 10 mg/day in known cyp2d6 poor metabolizers', and halves the dose alongside a strong cyp2d6 inhibitor. the same molecule is sold in singapore as brintellix and vortioson in 5, 10 and 20 mg, plus 20 mg/ml oral drops; the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["kidney or liver disease — healthhub","seizures, parkinson's, glaucoma or low blood sodium (hh)","bipolar disorder, mania or bleeding problems (healthhub)","under 25 — healthhub warns of new self-harm thoughts early on"],"clashes":[{"src":["hh_vor_avoid"],"food":true,"note":"healthhub: it can worsen depression symptoms and cause excessive sleepiness","with":"alcohol"},{"src":["fda_trin_cyp"],"note":"us label: the dose is halved while they are taken together","with":"strong cyp2d6 inhibitors (bupropion, fluoxetine, paroxetine, quinidine)"},{"src":["fda_trin_inducer"],"note":"us label: a dose increase is considered beyond 14 days together","with":"strong cyp inducers (rifampin, carbamazepine, phenytoin)"},{"src":["fda_trin_maoi"],"note":"us label: 14 days before starting, 21 days after stopping","with":"maois (psychiatric)"},{"src":["hh_vor_precautions"],"note":"healthhub: some may affect how it works or cause serious drug interactions","with":"st john's wort, other medicines and herbal remedies"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All seven registered vortioxetine products read 'Prescription Only' — BRINTELLIX FILM-COATED TABLETS 5/10/20MG, BRINTELLIX ORAL DROPS, SOLUTION 20MG/ML and VORTIOSON FILM-COATED TABLET 5/10/20MG, ATC N06AX26.","accessed":"2026-08-27"},{"id":"hh_vor_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/vortioxetine","label":"HealthHub (National Medication Information workgroup, SG) — Vortioxetine: what is this medication for","quote":"Vortioxetine belongs to a class of medications known as Multimodal Serotonergic antidepressants. It is used to treat symptoms of depression such as: Feeling sad, Loss of interest in usual activities, Feeling hopeless or useless","accessed":"2026-08-27"},{"id":"hh_vor_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/vortioxetine","label":"HealthHub — Vortioxetine: how should I take this medication","quote":"For Vortioxetine tablet: Vortioxetine may be taken with or without food … For Vortioxetine oral drops: … You may mix the oral drops with water, juice or other non-alcoholic drinks … unpleasant effects … if you suddenly stop","accessed":"2026-08-27"},{"id":"hh_vor_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/vortioxetine","label":"HealthHub — Vortioxetine: what precautions should I take","quote":"Kidney or liver disease … seizures (fits), Parkinson's disease, low sodium in the blood (hyponatremia), increased eye pressure (glaucoma), or bleeding problems … bipolar disorder, abnormally high or excited mood (mania)","accessed":"2026-08-27"},{"id":"hh_vor_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/vortioxetine","label":"HealthHub — Vortioxetine: common side effects","quote":"Nausea, vomiting or loss of appetite … Diarrhoea … Constipation … Dizziness … Dreams that are different from usual, decreased sexual drive or ability","accessed":"2026-08-27"},{"id":"hh_vor_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/vortioxetine","label":"HealthHub — Vortioxetine: what food or medication should I avoid","quote":"Avoid drinking alcohol while taking Vortioxetine as it can worsen the symptoms of your depression and cause excessive sleepiness.","accessed":"2026-08-27"},{"id":"hh_vor_young","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/vortioxetine","label":"HealthHub — Vortioxetine: important warning for people under 25","quote":"The following changes have been observed in some patients particularly below the age of 25 years … New or worsening thoughts of harming yourself or ending your life; Worsening agitation, restlessness, violent behaviour","accessed":"2026-08-27"},{"id":"fda_trin_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22TRINTELLIX%22&limit=1","label":"US FDA label for TRINTELLIX (vortioxetine), section 2.1 Recommended Dosage, via openFDA (Takeda, effective 2025-03-05)","quote":"The recommended starting dose is 10 mg administered orally once daily … Dosage should then be increased to 20 mg/day, as tolerated. The efficacy and safety of doses above 20 mg/day have not been evaluated in controlled clinical trials.","accessed":"2026-08-27"},{"id":"fda_trin_cyp","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22TRINTELLIX%22&limit=1","label":"US FDA label for TRINTELLIX, sections 2.5–2.6 CYP2D6 poor metabolizers, inhibitors and inducers, via openFDA","quote":"The maximum recommended dose of TRINTELLIX is 10 mg/day in known CYP2D6 poor metabolizers. Reduce the dose of TRINTELLIX by one-half when patients are receiving a CYP2D6 strong inhibitor (e.g., bupropion, fluoxetine, paroxetine, or quinidine) concomitantly.","accessed":"2026-08-27"},{"id":"fda_trin_maoi","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22TRINTELLIX%22&limit=1","label":"US FDA label for TRINTELLIX, section 2.4 switching to or from an MAOI, via openFDA","quote":"At least 14 days must elapse between discontinuation of a MAOI intended to treat psychiatric disorders and initiation of therapy with TRINTELLIX … at least 21 days must elapse after stopping TRINTELLIX before starting an MAOI","accessed":"2026-08-27"},{"id":"fda_trin_inducer","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22TRINTELLIX%22&limit=1","label":"US FDA label for TRINTELLIX, section 2.6 use with strong CYP inducers, via openFDA","quote":"Consider increasing the dose of TRINTELLIX when a strong CYP inducer (e.g., rifampin, carbamazepine, or phenytoin) is coadministered for greater than 14 days. The maximum recommended dose should not exceed three times the original dose.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:34.039038+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}