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Vitamin B5

Supplement vitamin energyskin & hair
Aka: pantothenic acid, calcium pantothenate, pantethine
Brands seen in Singapore: Jarrow Formulas, Life Extension, Natural Factors, Swanson Vitamins, Nutricost
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Coenzyme a synthesis · normal energy-yielding metabolism
When to take
No timing rule given
Take with
Any form · calcium pantothenate vs pantethine not compared
Pros & cons
Pros
  • Ai is 5 mg a day for adults; deficiency is rare
  • No UL — no human toxicity reported at high intakes
  • No known clinically relevant drug interactions
Cons
  • Skin/hair: small acne trials only — limited evidence
  • ~10 g/day doses: mild diarrhea, stomach upset
  • HSA cap 200 mg/day · many iherb doses are 500–1,000 mg
Sources
  1. NIH ODS — Pantothenic Acid Fact Sheet for Health Professionals (updated May 1, 2026; read via archive.org capture, see verify_notes) — Table 1 AIs, Introduction, Intakes and Status, Deficiency · read 2026-08-27
    what it says
    “19+ years 5 mg 5 mg 6 mg 7 mg … the synthesis of coenzyme A (CoA) … a typical mixed diet in the United States provides an estimated daily intake of about 6 mg … deficiency is rare”
  2. NIH ODS — Pantothenic Acid Fact Sheet for Health Professionals (updated May 1, 2026; read via archive.org capture, see verify_notes) — Dietary supplements · read 2026-08-27
    what it says
    “Some supplements contain pantethine … or more commonly, calcium pantothenate. No studies have compared the relative bioavailability … typically ranges from about 10 mg in multivitamin/multimineral products to up to 1,000 mg in supplements of B-complex vitamins or pantothenic acid alone”
  3. NIH ODS — Pantothenic Acid Fact Sheet for Health Professionals (updated May 1, 2026; read via archive.org capture, see verify_notes) — Health Risks from Excessive Pantothenic Acid · read 2026-08-27
    what it says
    “The FNB was unable to establish ULs for pantothenic acid because there are no reports of pantothenic acid toxicity in humans at high intakes. Some individuals taking large doses … (e.g., 10 g/day) develop mild diarrhea and gastrointestinal distress”
  4. NIH ODS — Pantothenic Acid Fact Sheet for Health Professionals (updated May 1, 2026; read via archive.org capture, see verify_notes) — Interactions with Medications · read 2026-08-27
    what it says
    “Pantothenic acid is not known to have any clinically relevant interactions with medications”
  5. NIH ODS — Pantothenic Acid Fact Sheet for Health Professionals (updated May 1, 2026; read via archive.org capture, see verify_notes) — Pantothenic Acid and Health — Hyperlipidemia · read 2026-08-27
    what it says
    “Several clinical trials have shown that the form of pantothenic acid known as pantethine reduces lipid levels when taken in large amounts, but pantothenic acid itself does not appear to have the same effects”
  6. Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic Review (Shields et al., JAMA Dermatology 2023) — abstract via Europe PMC · read 2026-08-27
    what it says
    “Studies of fair or good quality showed the potential benefit of vitamins B5 and D, botanical extracts (green tea), probiotics, and ω-3 fatty acids in the treatment of acne … Many studies were of small size”
  7. FDA — Daily Value on the Nutrition and Supplement Facts Labels, Reference Guide: Daily Values for Nutrients (content current as of 03/05/2024) · read 2026-08-27
    what it says
    “DVs are the recommended amounts of nutrients to consume or not to exceed each day … Pantothenic Acid … 5mg”
  8. HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020, January 2026 — clause 4.8, Table 4 Vitamins Limits + List of Health Claims · read 2026-08-27
    what it says
    “HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits … Vitamin B5 (pantothenic acid) 200mg … Contribute to normal energy-yielding metabolism • Biotin, vitamin B1, B2, B3, B5, B6, C, D”
  9. HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines GL-CHPB-1-012 Rev. No. 001, October 2025 — Annex A row 110 · read 2026-08-27
    what it says
    “110. Vitamin B5 (pantothenic acid) Restricted use in HS and TM … When for oral use by general adult population, the maximum recommended daily dose should not provide more than 200mg”
  10. iHerb Singapore — category page Vitamin B5 (Pantothenic Acid), default order, 11 results · read 2026-08-27
    what it says
    “Jarrow Formulas, Pantothenic Acid B5, 100 Veggie Caps … Life Extension, Pantothenic Acid, Vitamin B-5, 500 mg … Natural Factors, BioCoenzymated, B5, Pantethine, 450 mg … Swanson Vitamins, Pantesin Pantethine … Nutricost, Vitamin B5, 120 Capsules … NaturesPlus, Pantothenic Acid, Sustained Release, 1,000 mg”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.