{"ok":true,"entry":{"slug":"vitamin-b5","kind":"supplement","name":"vitamin b5","aliases":["pantothenic acid","calcium pantothenate","pantethine"],"brands_sg":["Jarrow Formulas","Life Extension","Natural Factors","Swanson Vitamins","Nutricost"],"class":"vitamin","tags":["energy","skin-hair"],"use_for":"coenzyme a synthesis · normal energy-yielding metabolism","use_after":"no timing rule given","use_duration":null,"take_with":"any form · calcium pantothenate vs pantethine not compared","pros":["ai is 5 mg a day for adults; deficiency is rare","no ul — no human toxicity reported at high intakes","no known clinically relevant drug interactions"],"cons":["skin/hair: small acne trials only — limited evidence","~10 g/day doses: mild diarrhea, stomach upset","hsa cap 200 mg/day · many iherb doses are 500–1,000 mg"],"dose_note":"ai is 5 mg a day for adults 19+, 6 mg in pregnancy and 7 mg when breastfeeding; no ul has been set because no human toxicity has been reported, though ~10 g/day has caused mild diarrhea; supplements typically range from ~10 mg in multis up to 1,000 mg in b-complex or stand-alone products; hsa's general-adult limit for health supplements in singapore is 200 mg a day","dosage":{"ul":null,"unit":"mg","fda_dv":"5 mg","rda_ai":"5 mg (AI, adults 19+)","ul_status":"none_established","population":"general adult","hsa_max_daily":"200 mg"},"ul_status":"none_established","sg_class":null,"cautions":["high cholesterol or triglycerides — pantethine (not plain b5) lowered lipids in small trials; ask your doctor rather than self-treating","acne — a 2023 systematic review found only small trials of b5; ask a doctor or pharmacist before relying on it"],"clashes":[],"sources":[{"id":"nih_ods_b5_intake","url":"https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/","label":"NIH ODS — Pantothenic Acid Fact Sheet for Health Professionals (updated May 1, 2026; read via archive.org capture, see verify_notes) — Table 1 AIs, Introduction, Intakes and Status, Deficiency","quote":"19+ years 5 mg 5 mg 6 mg 7 mg … the synthesis of coenzyme A (CoA) … a typical mixed diet in the United States provides an estimated daily intake of about 6 mg … deficiency is rare","accessed":"2026-08-27"},{"id":"nih_ods_b5_forms","url":"https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/","label":"NIH ODS — Pantothenic Acid Fact Sheet for Health Professionals (updated May 1, 2026; read via archive.org capture, see verify_notes) — Dietary supplements","quote":"Some supplements contain pantethine … or more commonly, calcium pantothenate. No studies have compared the relative bioavailability … typically ranges from about 10 mg in multivitamin/multimineral products to up to 1,000 mg in supplements of B-complex vitamins or pantothenic acid alone","accessed":"2026-08-27"},{"id":"nih_ods_b5_safety","url":"https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/","label":"NIH ODS — Pantothenic Acid Fact Sheet for Health Professionals (updated May 1, 2026; read via archive.org capture, see verify_notes) — Health Risks from Excessive Pantothenic Acid","quote":"The FNB was unable to establish ULs for pantothenic acid because there are no reports of pantothenic acid toxicity in humans at high intakes. Some individuals taking large doses … (e.g., 10 g/day) develop mild diarrhea and gastrointestinal distress","accessed":"2026-08-27"},{"id":"nih_ods_b5_interactions","url":"https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/","label":"NIH ODS — Pantothenic Acid Fact Sheet for Health Professionals (updated May 1, 2026; read via archive.org capture, see verify_notes) — Interactions with Medications","quote":"Pantothenic acid is not known to have any clinically relevant interactions with medications","accessed":"2026-08-27"},{"id":"nih_ods_b5_lipids","url":"https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/","label":"NIH ODS — Pantothenic Acid Fact Sheet for Health Professionals (updated May 1, 2026; read via archive.org capture, see verify_notes) — Pantothenic Acid and Health — Hyperlipidemia","quote":"Several clinical trials have shown that the form of pantothenic acid known as pantethine reduces lipid levels when taken in large amounts, but pantothenic acid itself does not appear to have the same effects","accessed":"2026-08-27"},{"id":"shields2023","url":"https://europepmc.org/article/PMC/PMC11015159","label":"Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic Review (Shields et al., JAMA Dermatology 2023) — abstract via Europe PMC","quote":"Studies of fair or good quality showed the potential benefit of vitamins B5 and D, botanical extracts (green tea), probiotics, and ω-3 fatty acids in the treatment of acne … Many studies were of small size","accessed":"2026-08-27"},{"id":"fda_dv","url":"https://www.fda.gov/food/nutrition-facts-label/daily-value-nutrition-and-supplement-facts-labels","label":"FDA — Daily Value on the Nutrition and Supplement Facts Labels, Reference Guide: Daily Values for Nutrients (content current as of 03/05/2024)","quote":"DVs are the recommended amounts of nutrients to consume or not to exceed each day … Pantothenic Acid … 5mg","accessed":"2026-08-27"},{"id":"hsa_hs_guidelines","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020, January 2026 — clause 4.8, Table 4 Vitamins Limits + List of Health Claims","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits … Vitamin B5 (pantothenic acid) 200mg … Contribute to normal energy-yielding metabolism • Biotin, vitamin B1, B2, B3, B5, B6, C, D","accessed":"2026-08-27"},{"id":"hsa_prohibited","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines GL-CHPB-1-012 Rev. No. 001, October 2025 — Annex A row 110","quote":"110. Vitamin B5 (pantothenic acid) Restricted use in HS and TM … When for oral use by general adult population, the maximum recommended daily dose should not provide more than 200mg","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/vitamin-b5-pantothenic-acid","label":"iHerb Singapore — category page Vitamin B5 (Pantothenic Acid), default order, 11 results","quote":"Jarrow Formulas, Pantothenic Acid B5, 100 Veggie Caps … Life Extension, Pantothenic Acid, Vitamin B-5, 500 mg … Natural Factors, BioCoenzymated, B5, Pantethine, 450 mg … Swanson Vitamins, Pantesin Pantethine … Nutricost, Vitamin B5, 120 Capsules … NaturesPlus, Pantothenic Acid, Sustained Release, 1,000 mg","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:34.039038+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}