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Vildagliptin

Medication DPP-4 inhibitor diabetes
Aka: Galvus
Brands seen in Singapore: Galvus, Galvus Met, Bidsiptin, Avexa Avildag
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Prescribed for type 2 diabetes, with diet and exercise
When to take
HealthHub: once or twice a day, before or after food
Take with
Water · smpc: with or without a meal
Pros & cons
Pros
  • HealthHub: raises insulin release after a meal
  • Smpc: low potential for drug-drug interactions
  • Smpc: no dose change needed at 65 and over
Cons
  • HealthHub: headache, dizziness, fatigue, tremor
  • Smpc: rare hepatic dysfunction; liver tests monitored
  • Smpc: linked to a risk of acute pancreatitis
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered locally) · read 2026-08-27
    what it says
    “All 6 registered vildagliptin products carry Forensicclassification 'Prescription Only' — SIN13407P Galvus Tablet 50mg · SIN13684/13685/13952P Galvus Met with metformin · SIN17250P BIDSIPTIN TABLET 50MG · SIN17509P AVEXA AVILDAG TABLET 50MG”
  2. HealthHub (Pharmaceutical Society of Singapore) — Vildagliptin: what is this medication for · read 2026-08-27
    what it says
    “Vildagliptin is used in the treatment of diabetes by helping to increase the insulin release after a meal and decrease the amount of sugar made by the liver.”
  3. HealthHub — Vildagliptin: how should I take or use this medication · read 2026-08-27
    what it says
    “This medication can be taken once or twice a day. You may take this medication before food or after food.”
  4. HealthHub — Vildagliptin: what precautions should I take · read 2026-08-27
    what it says
    “Are pregnant, planning to become pregnant or breastfeeding; Have pancreas problems such as pancreatitis; Have gallstones, drink alcohol very often or have very high levels of triglycerides … Have kidney or liver problems”
  5. HealthHub — Vildagliptin: common side effects · read 2026-08-27
    what it says
    “The common side effects of Vildagliptin include: Headache; Dizziness; Fatigue; Myalgia (muscle pain) and arthralgia (joint pain or stiffness); Tremor/shaking”
  6. HealthHub — Vildagliptin: what food or medication should I avoid · read 2026-08-27
    what it says
    “Avoid taking alcohol with this medication as this can increase your chances of developing pancreatitis.”
  7. EMA product information (EU summary of product characteristics) for Galvus 50 mg tablets, section 4.1 · read 2026-08-27
    what it says
    “Each tablet contains 50 mg of vildagliptin … when these do not provide adequate glycaemic control (see sections 4.4, 4.5 and 5.1 for available data on different combinations).”
  8. EMA product information for Galvus, section 4.2 Posology · read 2026-08-27
    what it says
    “the recommended daily dose of vildagliptin is 100 mg, administered as one dose of 50 mg in the morning and one dose of 50 mg in the evening … Doses higher than 100 mg are not recommended”
  9. EMA product information for Galvus, section 4.2 Posology — dual combination with a sulphonylurea · read 2026-08-27
    what it says
    “When used in dual combination with a sulphonylurea, the recommended dose of vildagliptin is 50 mg once daily administered in the morning. In this patient population, vildagliptin 100 mg daily was no more effective than vildagliptin 50 mg once daily.”
  10. EMA product information for Galvus, sections 4.2 and 4.4 — renal impairment · read 2026-08-27
    what it says
    “In patients with moderate or severe renal impairment or with end-stage renal disease (ESRD), the recommended dose of Galvus is 50 mg once daily … There is limited experience in patients with ESRD on haemodialysis.”
  11. EMA product information for Galvus, section 4.2 — elderly · read 2026-08-27
    what it says
    “No dose adjustments are necessary in elderly patients (see also sections 5.1 and 5.2).”
  12. EMA product information for Galvus, section 4.2 Method of administration · read 2026-08-27
    what it says
    “Oral use. Galvus can be administered with or without a meal (see also section 5.2).”
  13. EMA product information for Galvus, section 4.4 Special warnings and precautions for use · read 2026-08-27
    what it says
    “Galvus should not be used in patients with hepatic impairment … Rare cases of hepatic dysfunction (including hepatitis) have been reported … Use of vildagliptin has been associated with a risk of developing acute pancreatitis.”
  14. EMA product information for Galvus, section 4.5 Interactions · read 2026-08-27
    what it says
    “Vildagliptin has a low potential for interactions with co-administered medicinal products … There may be an increased risk of angioedema in patients concomitantly taking ACE-inhibitors … the hypoglycaemic effect may be reduced by thiazides, corticosteroids, thyroid products and sympathomimetics”
  15. EMA product information for Galvus, section 4.6 Fertility, pregnancy and lactation · read 2026-08-27
    what it says
    “Due to lack of human data, Galvus should not be used during pregnancy … It is unknown whether vildagliptin is excreted in human milk … Galvus should not be used during breast-feeding.”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.