{"ok":true,"entry":{"slug":"vildagliptin","kind":"medication","name":"vildagliptin","aliases":["Galvus"],"brands_sg":["Galvus","Galvus Met","Bidsiptin","Avexa Avildag"],"class":"DPP-4 inhibitor","tags":["diabetes"],"use_for":"prescribed for type 2 diabetes, with diet and exercise","use_after":"healthhub: once or twice a day, before or after food","use_duration":null,"take_with":"water · smpc: with or without a meal","pros":["healthhub: raises insulin release after a meal","smpc: low potential for drug-drug interactions","smpc: no dose change needed at 65 and over"],"cons":["healthhub: headache, dizziness, fatigue, tremor","smpc: rare hepatic dysfunction; liver tests monitored","smpc: linked to a risk of acute pancreatitis"],"dose_note":"the eu summary of product characteristics for galvus states 'the recommended daily dose of vildagliptin is 100 mg, administered as one dose of 50 mg in the morning and one dose of 50 mg in the evening' and, plainly, 'Doses higher than 100 mg are not recommended' — 100 mg a day is the label maximum. the same document gives 50 mg once daily with a sulphonylurea and in moderate or severe renal impairment. sg-registered galvus and generic tablets are 50 mg. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["liver problems — smpc: should not be used in hepatic impairment","kidney problems or dialysis — smpc: lower dose, and caution in esrd","a history of acute pancreatitis — smpc: caution","pregnancy or breastfeeding — smpc: should not be used"],"clashes":[{"src":["ema_galvus_di"],"note":"smpc: there may be an increased risk of angioedema when taken together","with":"ace inhibitors (ramipril, enalapril, lisinopril)"},{"src":["ema_galvus_warn","ema_galvus_su"],"note":"smpc: risk of hypoglycaemia; a lower sulphonylurea dose may be considered","with":"sulphonylureas"},{"src":["ema_galvus_di"],"note":"smpc: these may reduce the blood-sugar-lowering effect of vildagliptin","with":"thiazides, corticosteroids, thyroid products, sympathomimetics"},{"src":["hh_vilda_food"],"food":true,"note":"healthhub: can increase the chance of developing pancreatitis","with":"alcohol"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered locally)","quote":"All 6 registered vildagliptin products carry Forensicclassification 'Prescription Only' — SIN13407P Galvus Tablet 50mg · SIN13684/13685/13952P Galvus Met with metformin · SIN17250P BIDSIPTIN TABLET 50MG · SIN17509P AVEXA AVILDAG TABLET 50MG","accessed":"2026-08-27"},{"id":"hh_vilda_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/vildagliptin","label":"HealthHub (Pharmaceutical Society of Singapore) — Vildagliptin: what is this medication for","quote":"Vildagliptin is used in the treatment of diabetes by helping to increase the insulin release after a meal and decrease the amount of sugar made by the liver.","accessed":"2026-08-27"},{"id":"hh_vilda_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/vildagliptin","label":"HealthHub — Vildagliptin: how should I take or use this medication","quote":"This medication can be taken once or twice a day. You may take this medication before food or after food.","accessed":"2026-08-27"},{"id":"hh_vilda_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/vildagliptin","label":"HealthHub — Vildagliptin: what precautions should I take","quote":"Are pregnant, planning to become pregnant or breastfeeding; Have pancreas problems such as pancreatitis; Have gallstones, drink alcohol very often or have very high levels of triglycerides … Have kidney or liver problems","accessed":"2026-08-27"},{"id":"hh_vilda_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/vildagliptin","label":"HealthHub — Vildagliptin: common side effects","quote":"The common side effects of Vildagliptin include: Headache; Dizziness; Fatigue; Myalgia (muscle pain) and arthralgia (joint pain or stiffness); Tremor/shaking","accessed":"2026-08-27"},{"id":"hh_vilda_food","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/vildagliptin","label":"HealthHub — Vildagliptin: what food or medication should I avoid","quote":"Avoid taking alcohol with this medication as this can increase your chances of developing pancreatitis.","accessed":"2026-08-27"},{"id":"ema_galvus_about","url":"https://www.ema.europa.eu/en/documents/product-information/galvus-epar-product-information_en.pdf","label":"EMA product information (EU summary of product characteristics) for Galvus 50 mg tablets, section 4.1","quote":"Each tablet contains 50 mg of vildagliptin … when these do not provide adequate glycaemic control (see sections 4.4, 4.5 and 5.1 for available data on different combinations).","accessed":"2026-08-27"},{"id":"ema_galvus_dose","url":"https://www.ema.europa.eu/en/documents/product-information/galvus-epar-product-information_en.pdf","label":"EMA product information for Galvus, section 4.2 Posology","quote":"the recommended daily dose of vildagliptin is 100 mg, administered as one dose of 50 mg in the morning and one dose of 50 mg in the evening … Doses higher than 100 mg are not recommended","accessed":"2026-08-27"},{"id":"ema_galvus_su","url":"https://www.ema.europa.eu/en/documents/product-information/galvus-epar-product-information_en.pdf","label":"EMA product information for Galvus, section 4.2 Posology — dual combination with a sulphonylurea","quote":"When used in dual combination with a sulphonylurea, the recommended dose of vildagliptin is 50 mg once daily administered in the morning. In this patient population, vildagliptin 100 mg daily was no more effective than vildagliptin 50 mg once daily.","accessed":"2026-08-27"},{"id":"ema_galvus_renal","url":"https://www.ema.europa.eu/en/documents/product-information/galvus-epar-product-information_en.pdf","label":"EMA product information for Galvus, sections 4.2 and 4.4 — renal impairment","quote":"In patients with moderate or severe renal impairment or with end-stage renal disease (ESRD), the recommended dose of Galvus is 50 mg once daily … There is limited experience in patients with ESRD on haemodialysis.","accessed":"2026-08-27"},{"id":"ema_galvus_elderly","url":"https://www.ema.europa.eu/en/documents/product-information/galvus-epar-product-information_en.pdf","label":"EMA product information for Galvus, section 4.2 — elderly","quote":"No dose adjustments are necessary in elderly patients (see also sections 5.1 and 5.2).","accessed":"2026-08-27"},{"id":"ema_galvus_route","url":"https://www.ema.europa.eu/en/documents/product-information/galvus-epar-product-information_en.pdf","label":"EMA product information for Galvus, section 4.2 Method of administration","quote":"Oral use. Galvus can be administered with or without a meal (see also section 5.2).","accessed":"2026-08-27"},{"id":"ema_galvus_warn","url":"https://www.ema.europa.eu/en/documents/product-information/galvus-epar-product-information_en.pdf","label":"EMA product information for Galvus, section 4.4 Special warnings and precautions for use","quote":"Galvus should not be used in patients with hepatic impairment … Rare cases of hepatic dysfunction (including hepatitis) have been reported … Use of vildagliptin has been associated with a risk of developing acute pancreatitis.","accessed":"2026-08-27"},{"id":"ema_galvus_di","url":"https://www.ema.europa.eu/en/documents/product-information/galvus-epar-product-information_en.pdf","label":"EMA product information for Galvus, section 4.5 Interactions","quote":"Vildagliptin has a low potential for interactions with co-administered medicinal products … There may be an increased risk of angioedema in patients concomitantly taking ACE-inhibitors … the hypoglycaemic effect may be reduced by thiazides, corticosteroids, thyroid products and sympathomimetics","accessed":"2026-08-27"},{"id":"ema_galvus_preg","url":"https://www.ema.europa.eu/en/documents/product-information/galvus-epar-product-information_en.pdf","label":"EMA product information for Galvus, section 4.6 Fertility, pregnancy and lactation","quote":"Due to lack of human data, Galvus should not be used during pregnancy … It is unknown whether vildagliptin is excreted in human milk … Galvus should not be used during breast-feeding.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:34.039038+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}