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Urolithin A

Supplement postbiotic metabolite fitnessgeneral nutrition
Aka: Mitopure
Brands seen in Singapore: Timeline, Codeage, ProHealth Longevity, Neurogan Health, Nutri
Third-party tested: Timeline lists a certified urolithin a product with NSF Certified for Sport. Codeage certifies other products with NSF Certified for Sport, but nothing for urolithin a.Certification is granted per product, so check the tub you actually own. Not being listed is not the same as failing.
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Limited human evidence — 5 small trials on muscle endpoints
Pros & cons
Pros
  • Pooled trials used 500 mg or 1,000 mg a day
  • Not named in HSA's prohibited or restricted annexes
Cons
  • Pooled 6-min walk gain was not significant (p = 0.135)
  • GRADE certainty low; 5 small trials, n = 236 total
  • Human cases of urolithin A kidney stones are reported
Sources
  1. Effects of Urolithin A supplementation on muscle health outcomes in humans from randomized controlled trials (Front Nutr 2026, systematic review and meta-analysis) · read 2026-08-27
    what it says
    “Five randomized controlled trials (n = 236) were included … the pooled mean difference was +17.03 m (95% CI -5.33 to 39.40 m; p = 0.135) … The certainty of evidence for the 6MWT outcome was rated as low (GRADE)”
  2. First Reported Human Cases of Urolithin A Renal Calculi (Kidney Int Rep 2026) · read 2026-08-27
    what it says
    “First Reported Human Cases of Urolithin A Renal Calculi”
  3. HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annexes A and B · read 2026-08-27
    what it says
    “Annex A: List of substances which are prohibited or restricted for use with conditions … Annex B: List of substances with potential safety issues [urolithin A appears in neither annex]”
  4. HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits · read 2026-08-27
    what it says
    “Table 4: Vitamins Limits … Table 5: Minerals Limits [neither table names urolithin A]”
  5. iHerb Singapore — Urolithin A · read 2026-08-27
    what it says
    “1 - 10 of 10 results; Timeline, Urolithin A, 60 Softgels; Codeage, Liposomal Urolithin A, Eternal, 60 Vegetable Capsules; ProHealth Longevity, Full Spectrum Urolithin A, 60 Capsules; Neurogan Health, Pro+ Urolithin, Precursor, 120 Capsules; Nutri, Urolithin A Diacetate”
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Updated 2026-08-30. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.