{"ok":true,"entry":{"slug":"urolithin-a","kind":"supplement","name":"urolithin A","aliases":["Mitopure"],"brands_sg":["Timeline","Codeage","ProHealth Longevity","Neurogan Health","Nutri"],"class":"postbiotic metabolite","tags":["fitness","general"],"use_for":"limited human evidence — 5 small trials on muscle endpoints","use_after":null,"use_duration":null,"take_with":null,"pros":["pooled trials used 500 mg or 1,000 mg a day","not named in HSA's prohibited or restricted annexes"],"cons":["pooled 6-min walk gain was not significant (p = 0.135)","GRADE certainty low; 5 small trials, n = 236 total","human cases of urolithin A kidney stones are reported"],"dose_note":"the pooled RCTs used 500 mg and 1,000 mg a day; the meta-analysis calls the non-walk-test findings exploratory rather than reproducible evidence","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["kidney stone history — human urolithin A calculi are reported","no upper limit set — absence of a cap is not safety"],"clashes":[],"sources":[{"id":"uroa_meta","url":"https://europepmc.org/article/MED/42559151","label":"Effects of Urolithin A supplementation on muscle health outcomes in humans from randomized controlled trials (Front Nutr 2026, systematic review and meta-analysis)","quote":"Five randomized controlled trials (n = 236) were included … the pooled mean difference was +17.03 m (95% CI -5.33 to 39.40 m; p = 0.135) … The certainty of evidence for the 6MWT outcome was rated as low (GRADE)","accessed":"2026-08-27"},{"id":"uroa_stone","url":"https://europepmc.org/article/PMC/PMC13123385","label":"First Reported Human Cases of Urolithin A Renal Calculi (Kidney Int Rep 2026)","quote":"First Reported Human Cases of Urolithin A Renal Calculi","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annexes A and B","quote":"Annex A: List of substances which are prohibited or restricted for use with conditions … Annex B: List of substances with potential safety issues [urolithin A appears in neither annex]","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits","quote":"Table 4: Vitamins Limits … Table 5: Minerals Limits [neither table names urolithin A]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/urolithin-a","label":"iHerb Singapore — Urolithin A","quote":"1 - 10 of 10 results; Timeline, Urolithin A, 60 Softgels; Codeage, Liposomal Urolithin A, Eternal, 60 Vegetable Capsules; ProHealth Longevity, Full Spectrum Urolithin A, 60 Capsules; Neurogan Health, Pro+ Urolithin, Precursor, 120 Capsules; Nutri, Urolithin A Diacetate","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Timeline","example":"Longevity Supplement – Mitopure (Urolithin A) Berry Powder – Timeline","programme":"NSF Certified for Sport","matching_products":4,"brand_total_certified":4},{"brand":"Codeage","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":1}],"updated_at":"2026-08-30T17:59:39.960259+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}