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Undenatured type II collagen

Supplement collagen bone & joint
Aka: UC-II, type II collagen
Brands seen in Singapore: California Gold Nutrition, Vital Proteins, NOW Foods, Youtheory, NeoCell
Third-party tested: Vital Proteins certifies other products with NSF Certified for Sport, but nothing for undenatured type ii collagen.Certification is granted per product, so check the tub you actually own. Not being listed is not the same as failing.
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Joint function and comfort, studied in knee osteoarthritis
When to take
Daily
Studied for
One trial ran 180 days at 40 mg a day
Pros & cons
Pros
  • 40 mg a day is the dose used in trials
  • Rated safe short- and mid-term in one review
Cons
  • Long-term efficacy is not established yet
  • Placebo also improved in the 180-day trial
  • One review was qualitative, not a meta-analysis
Sources
  1. Undenatured type II collagen for knee osteoarthritis (Gupta & Maffulli, Annals of Medicine 2025) — PRISMA-guided narrative review · read 2026-08-27
    what it says
    “qualitatively presents the pre-clinical, clinical and on-going scientific literature … administration of UC-2 (40 mg daily) is safe and efficacious in the short- and mid-term … more adequately powered … randomized controlled trials with longer follow-up are warranted”
  2. Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomised trial (Nutrition Journal 2026) · read 2026-08-27
    what it says
    “Participants were randomized to receive placebo (PBO) or native (undenatured) type-II collagen (CN2) at 40 mg/d for 180 days … In both groups a significant improvement in joint function measured with the KOOS score was detected at 180 days”
  3. HSA — Guidelines on health supplements (Singapore), maximum daily limits Tables 4–5 · read 2026-08-27
    what it says
    “Table 4: Vitamins Limits … Nutrient Maximum Daily Limit … Table 5: Minerals Limits”
  4. HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annex A/B · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  5. iHerb Singapore — Collagen Supplements category page (default best-selling order) · read 2026-08-27
    what it says
    “Collagen Supplements”
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Updated 2026-08-30. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.