{"ok":true,"entry":{"slug":"ucii-collagen","kind":"supplement","name":"undenatured type II collagen","aliases":["UC-II","type II collagen"],"brands_sg":["California Gold Nutrition","Vital Proteins","NOW Foods","Youtheory","NeoCell"],"class":"collagen","tags":["bone-joint"],"use_for":"joint function and comfort, studied in knee osteoarthritis","use_after":"daily","use_duration":"one trial ran 180 days at 40 mg a day","take_with":null,"pros":["40 mg a day is the dose used in trials","rated safe short- and mid-term in one review"],"cons":["long-term efficacy is not established yet","placebo also improved in the 180-day trial","one review was qualitative, not a meta-analysis"],"dose_note":"trials use 40 mg a day; one ran 180 days in healthy adults with activity-related joint discomfort","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":[],"clashes":[],"sources":[{"id":"gupta2025","url":"https://europepmc.org/article/PMC/PMC12010644","label":"Undenatured type II collagen for knee osteoarthritis (Gupta & Maffulli, Annals of Medicine 2025) — PRISMA-guided narrative review","quote":"qualitatively presents the pre-clinical, clinical and on-going scientific literature … administration of UC-2 (40 mg daily) is safe and efficacious in the short- and mid-term … more adequately powered … randomized controlled trials with longer follow-up are warranted","accessed":"2026-08-27"},{"id":"nutrj2026","url":"https://europepmc.org/article/PMC/PMC13077837","label":"Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomised trial (Nutrition Journal 2026)","quote":"Participants were randomized to receive placebo (PBO) or native (undenatured) type-II collagen (CN2) at 40 mg/d for 180 days … In both groups a significant improvement in joint function measured with the KOOS score was detected at 180 days","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Guidelines on health supplements (Singapore), maximum daily limits Tables 4–5","quote":"Table 4: Vitamins Limits … Nutrient Maximum Daily Limit … Table 5: Minerals Limits","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annex A/B","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/collagen-supplements","label":"iHerb Singapore — Collagen Supplements category page (default best-selling order)","quote":"Collagen Supplements","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Vital Proteins","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":9}],"updated_at":"2026-08-30T17:59:36.026222+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}