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Ubiquinol

Supplement coenzyme heart & metabolicenergy
Aka: reduced CoQ10, Kaneka ubiquinol
Brands seen in Singapore: California Gold Nutrition, Doctor's Best, NOW Foods, Life Extension, Qunol
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Reduced form of CoQ10 · heart evidence inconclusive
When to take
Daily use
Studied for
Plasma CoQ10 rose by 6 weeks
Pros & cons
Pros
  • A 12-person trial found better uptake than ubiquinone
  • NCCIH: no serious side effects have been reported
Cons
  • NCCIH: no benefit shown for statin muscle pain
  • NCCIH: probably no meaningful effect on blood pressure
  • 6 weeks at 300 mg didn't raise exercise capacity
Sources
  1. NIH NCCIH — Coenzyme Q10 (Bottom Line) · read 2026-08-27
    what it says
    “CoQ10 in heart failure is also inconclusive … the overall scientific evidence does not support the idea that CoQ10 can reduce muscle pain caused by … statins … probably doesn't have a meaningful effect on blood pressure”
  2. NIH NCCIH — Coenzyme Q10 (Safety) · read 2026-08-27
    what it says
    “No serious side effects of CoQ10 have been reported. Mild side effects such as insomnia or digestive upsets may occur. CoQ10 may interact with the anticoagulant (blood thinner) warfarin and the diabetes drug insulin”
  3. Crossover bioavailability of a cocrystal ubiquinol vs a ubiquinone formulation (Clin Pharmacol Drug Dev, 2026) · read 2026-08-27
    what it says
    “randomized, double-blind, two-period crossover study with 12 healthy subjects under fasting conditions … the test ubiquinol formulation demonstrated substantially higher relative systemic bioavailability compared with the ubiquinone reference”
  4. Six weeks ubiquinol supplementation, mitochondrial respiratory function and exercise capacity (Eur J Appl Physiol, 2026) · read 2026-08-27
    what it says
    “randomised to receive either 300 mg·day-1 UQH2 or placebo (PLA) for 6 weeks … Six-weeks UQH2 supplementation increased plasma [CoQ10] and oxidative phosphorylation coupling efficiency … TLim were not different between groups post-supplementation”
  5. HSA prohibited/restricted ingredients in HS and TM (Oct 2025), Annex A item 30 — Coenzyme Q10 · read 2026-08-27
    what it says
    “Coenzyme Q10 … Restricted use in HS and TM … the maximum recommended daily dose should not provide more than 150mg … "Do not take while on warfarin therapy without medical advice."”
  6. HSA Guidelines on prohibited and restricted ingredients in HS and TM (GL-CHPB-1-012, Oct 2025), s1.3 / Annex A · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  7. iHerb Singapore — CoQ10 category (default best-selling order) · read 2026-08-27
    what it says
    “California Gold Nutrition … Doctor's Best … NOW Foods … Life Extension … Qunol”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.