{"ok":true,"entry":{"slug":"ubiquinol","kind":"supplement","name":"ubiquinol","aliases":["reduced CoQ10","Kaneka ubiquinol"],"brands_sg":["California Gold Nutrition","Doctor's Best","NOW Foods","Life Extension","Qunol"],"class":"coenzyme","tags":["heart","energy"],"use_for":"reduced form of coq10 · heart evidence inconclusive","use_after":"daily use","use_duration":"plasma coq10 rose by 6 weeks","take_with":null,"pros":["a 12-person trial found better uptake than ubiquinone","nccih: no serious side effects have been reported"],"cons":["nccih: no benefit shown for statin muscle pain","nccih: probably no meaningful effect on blood pressure","6 weeks at 300 mg didn't raise exercise capacity"],"dose_note":"hsa caps coq10 in sg health supplements at 150 mg a day; a 6-week ubiquinol trial used 300 mg a day","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":150},"ul_status":"none_established","sg_class":null,"cautions":["warfarin — hsa requires the label statement \"Do not take while on warfarin therapy without medical advice.\"","mild insomnia or digestive upset has been reported","cancer treatment — nccih notes coq10 may not be compatible with some types","hsa's restricted list is not exhaustive; a listing is a limit, not a safety clearance"],"clashes":[{"src":["hsa_pr_coq10","nccih_coq10_safety"],"note":"hsa mandates a medical-advice label; nccih lists warfarin as an interaction","with":"warfarin"},{"src":["nccih_coq10_safety"],"note":"nccih lists the diabetes drug insulin as a possible interaction","with":"insulin"}],"sources":[{"id":"nccih_coq10","url":"https://www.nccih.nih.gov/health/coenzyme-q10","label":"NIH NCCIH — Coenzyme Q10 (Bottom Line)","quote":"CoQ10 in heart failure is also inconclusive … the overall scientific evidence does not support the idea that CoQ10 can reduce muscle pain caused by … statins … probably doesn't have a meaningful effect on blood pressure","accessed":"2026-08-27"},{"id":"nccih_coq10_safety","url":"https://www.nccih.nih.gov/health/coenzyme-q10","label":"NIH NCCIH — Coenzyme Q10 (Safety)","quote":"No serious side effects of CoQ10 have been reported. Mild side effects such as insomnia or digestive upsets may occur. CoQ10 may interact with the anticoagulant (blood thinner) warfarin and the diabetes drug insulin","accessed":"2026-08-27"},{"id":"ubiq_bioav","url":"https://europepmc.org/article/PMC/PMC12965043","label":"Crossover bioavailability of a cocrystal ubiquinol vs a ubiquinone formulation (Clin Pharmacol Drug Dev, 2026)","quote":"randomized, double-blind, two-period crossover study with 12 healthy subjects under fasting conditions … the test ubiquinol formulation demonstrated substantially higher relative systemic bioavailability compared with the ubiquinone reference","accessed":"2026-08-27"},{"id":"ejap2026","url":"https://europepmc.org/article/MED/42249931","label":"Six weeks ubiquinol supplementation, mitochondrial respiratory function and exercise capacity (Eur J Appl Physiol, 2026)","quote":"randomised to receive either 300 mg·day-1 UQH2 or placebo (PLA) for 6 weeks … Six-weeks UQH2 supplementation increased plasma [CoQ10] and oxidative phosphorylation coupling efficiency … TLim were not different between groups post-supplementation","accessed":"2026-08-27"},{"id":"hsa_pr_coq10","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA prohibited/restricted ingredients in HS and TM (Oct 2025), Annex A item 30 — Coenzyme Q10","quote":"Coenzyme Q10 … Restricted use in HS and TM … the maximum recommended daily dose should not provide more than 150mg … \"Do not take while on warfarin therapy without medical advice.\"","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Guidelines on prohibited and restricted ingredients in HS and TM (GL-CHPB-1-012, Oct 2025), s1.3 / Annex A","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/coq10","label":"iHerb Singapore — CoQ10 category (default best-selling order)","quote":"California Gold Nutrition … Doctor's Best … NOW Foods … Life Extension … Qunol","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:33.302383+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}