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Topiramate

Medication anticonvulsant other
Aka: Topamax
Brands seen in Singapore: Topamax, Trokendi XR, Topiron
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Seizures in epilepsy, and prevention of migraine
When to take
SG label: without regard to meals · usually two daily doses
Take with
A glass of water · SG label: tablets not to be broken
Pros & cons
Pros
  • SG label: used alone or added to other epilepsy drugs
  • Also registered in SG for migraine prophylaxis
  • HealthHub: may be crushed into soft food if needed
Cons
  • Dizziness, drowsiness and blurred vision are common
  • Kidney stones and reduced sweating are label risks
  • SG label: contraindicated in pregnancy for migraine use
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg d_767279312753558cbf19d48344577084), Forensicclassification column; cached at /tmp/hsa_all.json and filtered locally, not re-fetched · read 2026-08-27
    what it says
    “TOPAMAX 100 TABLET 100 mg SIN09687P | TOPIRAMATE | Prescription Only | N03AX11; TOPAMAX 50 SIN09689P; TOPAMAX 25 SIN09688P; TROKENDI XR 25/50/100/200MG SIN16662P-SIN16665P; Topiron 25/50/100mg SIN14132P, SIN14131P, SIN14311P — all 10 topiramate rows Prescription Only”
  2. MOH National Drug Formulary (Singapore) — TOPAMAX 100 TABLET 100 MG [SIN09687P], product information · read 2026-08-27
    what it says
    “TOPIRAMATE - 100 MG … Forensic Classification PRESCRIPTION ONLY MEDICINES … Anatomical Therapeutic Chemical (ATC) code N03AX11 … Prescription-only Medicines with Exemptions for Supply without Prescription NA”
  3. MOH National Drug Formulary (Singapore) — TOPAMAX [SIN09687P], Indications · read 2026-08-27
    what it says
    “TOPAMAX® is indicated as monotherapy for adults and children with partial onset seizures and generalized seizures … TOPAMAX® is also indicated for adults for the prophylaxis of migraine headache.”
  4. MOH National Drug Formulary (Singapore) — TOPAMAX [SIN09687P], Dosage: epilepsy monotherapy in adults · read 2026-08-27
    what it says
    “The recommended initial target dose for topiramate monotherapy in adults is 100 mg/day and the maximum recommended daily dose is 500 mg.”
  5. MOH National Drug Formulary (Singapore) — TOPAMAX [SIN09687P], Dosage: migraine prophylaxis in adults · read 2026-08-27
    what it says
    “The recommended total daily dose of topiramate as treatment for prophylaxis of migraine headache is 100 mg/day administered in two divided doses … Patients have received a total daily dose up to 200 mg/day.”
  6. MOH National Drug Formulary (Singapore) — TOPAMAX [SIN09687P], Administration · read 2026-08-27
    what it says
    “TOPAMAX® (topiramate) is available in tablets for oral administration. It is recommended that TOPAMAX® tablets not be broken. TOPAMAX® can be taken without regard to meals.”
  7. MOH National Drug Formulary (Singapore) — TOPAMAX [SIN09687P], renal impairment · read 2026-08-27
    what it says
    “Patients with renal impairment (CL CR <70mL/min) may require a dose reduction. Half of the usual starting and maintenance dose is recommended”
  8. MOH National Drug Formulary (Singapore) — TOPAMAX [SIN09687P], Contraindications · read 2026-08-27
    what it says
    “Hypersensitivity to any component of this product. Migraine prophylaxis: in pregnancy and in women of childbearing potential if not using a highly effective method of contraception.”
  9. HealthHub (MOH Singapore) — Topiramate, medication information leaflet · read 2026-08-27
    what it says
    “Topiramate is used to control seizures (fits) and other problems related to the nervous system. It can also be used for migraine prevention.”
  10. HealthHub (MOH Singapore) — Topiramate, how to take it · read 2026-08-27
    what it says
    “You can take this medication with or without food. Swallow the tablets with a glass of water. If you are unable to swallow the tablet, you may crush it and add it to a small amount of food”
  11. HealthHub (MOH Singapore) — Topiramate, precautions · read 2026-08-27
    what it says
    “Eye problems, especially glaucoma Liver problems Kidney problems, especially history of kidney stones or are getting dialysis History of metabolic acidosis (blood and body fluid abnormality) On ketogenic diet”
  12. HealthHub (MOH Singapore) — Topiramate, common side effects · read 2026-08-27
    what it says
    “The common side effects of Topiramate include: Dizziness … Drowsiness or double vision or blurred vision … Loose stools (Diarrhoea) … Nausea, vomiting … Loss of appetite or weight loss Reduced sweating and increased body temperature”
  13. HealthHub (MOH Singapore) — Topiramate, rare but serious side effects · read 2026-08-27
    what it says
    “Difficulty or pain in urinating, blood in urine, sudden reduction in urine volume, lower back pain Kidney stones … Sudden worsening in eyesight, red eye or eye pain”
  14. HealthHub (MOH Singapore) — Topiramate, food and medication to avoid · read 2026-08-27
    what it says
    “Avoid drinking alcohol while taking this medication as it can cause excessive drowsiness.”
  15. NHS medicines A–Z — Topiramate, taking it with other medicines, food and drink (reviewed 29 July 2026) · read 2026-08-27
    what it says
    “There are some medicines, herbal remedies and supplements that may not mix well with topiramate. These include: hormonal contraceptives, such as the combined pill … any other medicines for epilepsy”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.