{"ok":true,"entry":{"slug":"topiramate","kind":"medication","name":"topiramate","aliases":["Topamax"],"brands_sg":["Topamax","Trokendi XR","Topiron"],"class":"anticonvulsant","tags":["other"],"use_for":"seizures in epilepsy, and prevention of migraine","use_after":"sg label: without regard to meals · usually two daily doses","use_duration":null,"take_with":"a glass of water · sg label: tablets not to be broken","pros":["sg label: used alone or added to other epilepsy drugs","also registered in sg for migraine prophylaxis","healthhub: may be crushed into soft food if needed"],"cons":["dizziness, drowsiness and blurred vision are common","kidney stones and reduced sweating are label risks","sg label: contraindicated in pregnancy for migraine use"],"dose_note":"the sg topamax label states that for epilepsy monotherapy in adults \"The recommended initial target dose for topiramate monotherapy in adults is 100 mg/day and the maximum recommended daily dose is 500 mg\", while for migraine \"The recommended total daily dose of topiramate as treatment for prophylaxis of migraine headache is 100 mg/day administered in two divided doses\" — the two ceilings are for different uses; as directed on the label or by your doctor","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["eye problems, especially glaucoma — healthhub asks that this be declared before starting","kidney problems, a history of kidney stones, or dialysis — healthhub precaution; the sg label halves the dose below 70 mL/min creatinine clearance","pregnancy or the chance of pregnancy — the sg label contraindicates migraine prophylaxis without highly effective contraception","liver problems, past metabolic acidosis, or a ketogenic diet — healthhub asks that these be declared"],"clashes":[{"src":["nhs_topiramate_int"],"note":"nhs: may not mix well with topiramate; another method such as condoms may be recommended","with":"hormonal contraceptives such as the combined pill"},{"src":["nhs_topiramate_int"],"note":"nhs lists them among medicines that may not mix well with topiramate","with":"other epilepsy medicines"},{"src":["hh_topiramate_food","nhs_topiramate_int"],"food":true,"note":"healthhub: can cause excessive drowsiness; nhs adds it may raise the chance of a seizure","with":"alcohol"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/api/action/datastore_search?resource_id=d_767279312753558cbf19d48344577084&limit=6000","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg d_767279312753558cbf19d48344577084), Forensicclassification column; cached at /tmp/hsa_all.json and filtered locally, not re-fetched","quote":"TOPAMAX 100 TABLET 100 mg SIN09687P | TOPIRAMATE | Prescription Only | N03AX11; TOPAMAX 50 SIN09689P; TOPAMAX 25 SIN09688P; TROKENDI XR 25/50/100/200MG SIN16662P-SIN16665P; Topiron 25/50/100mg SIN14132P, SIN14131P, SIN14311P — all 10 topiramate rows Prescription Only","accessed":"2026-08-27"},{"id":"ndf_topamax","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin09687p/","label":"MOH National Drug Formulary (Singapore) — TOPAMAX 100 TABLET 100 MG [SIN09687P], product information","quote":"TOPIRAMATE - 100 MG … Forensic Classification PRESCRIPTION ONLY MEDICINES … Anatomical Therapeutic Chemical (ATC) code N03AX11 … Prescription-only Medicines with Exemptions for Supply without Prescription NA","accessed":"2026-08-27"},{"id":"ndf_topamax_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin09687p/","label":"MOH National Drug Formulary (Singapore) — TOPAMAX [SIN09687P], Indications","quote":"TOPAMAX® is indicated as monotherapy for adults and children with partial onset seizures and generalized seizures … TOPAMAX® is also indicated for adults for the prophylaxis of migraine headache.","accessed":"2026-08-27"},{"id":"ndf_topamax_dose_mono","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin09687p/","label":"MOH National Drug Formulary (Singapore) — TOPAMAX [SIN09687P], Dosage: epilepsy monotherapy in adults","quote":"The recommended initial target dose for topiramate monotherapy in adults is 100 mg/day and the maximum recommended daily dose is 500 mg.","accessed":"2026-08-27"},{"id":"ndf_topamax_dose_mig","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin09687p/","label":"MOH National Drug Formulary (Singapore) — TOPAMAX [SIN09687P], Dosage: migraine prophylaxis in adults","quote":"The recommended total daily dose of topiramate as treatment for prophylaxis of migraine headache is 100 mg/day administered in two divided doses … Patients have received a total daily dose up to 200 mg/day.","accessed":"2026-08-27"},{"id":"ndf_topamax_admin","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin09687p/","label":"MOH National Drug Formulary (Singapore) — TOPAMAX [SIN09687P], Administration","quote":"TOPAMAX® (topiramate) is available in tablets for oral administration. It is recommended that TOPAMAX® tablets not be broken. TOPAMAX® can be taken without regard to meals.","accessed":"2026-08-27"},{"id":"ndf_topamax_renal","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin09687p/","label":"MOH National Drug Formulary (Singapore) — TOPAMAX [SIN09687P], renal impairment","quote":"Patients with renal impairment (CL CR <70mL/min) may require a dose reduction. Half of the usual starting and maintenance dose is recommended","accessed":"2026-08-27"},{"id":"ndf_topamax_ci","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin09687p/","label":"MOH National Drug Formulary (Singapore) — TOPAMAX [SIN09687P], Contraindications","quote":"Hypersensitivity to any component of this product. Migraine prophylaxis: in pregnancy and in women of childbearing potential if not using a highly effective method of contraception.","accessed":"2026-08-27"},{"id":"hh_topiramate","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/topiramate","label":"HealthHub (MOH Singapore) — Topiramate, medication information leaflet","quote":"Topiramate is used to control seizures (fits) and other problems related to the nervous system. It can also be used for migraine prevention.","accessed":"2026-08-27"},{"id":"hh_topiramate_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/topiramate","label":"HealthHub (MOH Singapore) — Topiramate, how to take it","quote":"You can take this medication with or without food. Swallow the tablets with a glass of water. If you are unable to swallow the tablet, you may crush it and add it to a small amount of food","accessed":"2026-08-27"},{"id":"hh_topiramate_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/topiramate","label":"HealthHub (MOH Singapore) — Topiramate, precautions","quote":"Eye problems, especially glaucoma Liver problems Kidney problems, especially history of kidney stones or are getting dialysis History of metabolic acidosis (blood and body fluid abnormality) On ketogenic diet","accessed":"2026-08-27"},{"id":"hh_topiramate_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/topiramate","label":"HealthHub (MOH Singapore) — Topiramate, common side effects","quote":"The common side effects of Topiramate include: Dizziness … Drowsiness or double vision or blurred vision … Loose stools (Diarrhoea) … Nausea, vomiting … Loss of appetite or weight loss Reduced sweating and increased body temperature","accessed":"2026-08-27"},{"id":"hh_topiramate_rare","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/topiramate","label":"HealthHub (MOH Singapore) — Topiramate, rare but serious side effects","quote":"Difficulty or pain in urinating, blood in urine, sudden reduction in urine volume, lower back pain Kidney stones … Sudden worsening in eyesight, red eye or eye pain","accessed":"2026-08-27"},{"id":"hh_topiramate_food","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/topiramate","label":"HealthHub (MOH Singapore) — Topiramate, food and medication to avoid","quote":"Avoid drinking alcohol while taking this medication as it can cause excessive drowsiness.","accessed":"2026-08-27"},{"id":"nhs_topiramate_int","url":"https://www.nhs.uk/medicines/topiramate/","label":"NHS medicines A–Z — Topiramate, taking it with other medicines, food and drink (reviewed 29 July 2026)","quote":"There are some medicines, herbal remedies and supplements that may not mix well with topiramate. These include: hormonal contraceptives, such as the combined pill … any other medicines for epilepsy","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:33.302383+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}