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Sucralfate

Medication mucosal protectant digestive
Aka: Ulsanic, Carafate
Brands seen in Singapore: Apo-Sucralfate
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Prescribed for ulcers in the gut lining
When to take
HealthHub: half to one hour before food
Take with
Water on an empty stomach · 2 h from other medicines
Pros & cons
Pros
  • HealthHub: treats and prevents ulcers in the gut
  • FDA: adverse effects in 129 of 2,700+ patients (4.7%)
  • FDA: other drugs 2 h earlier ends the interaction
Cons
  • FDA: constipation was the most frequent complaint (2%)
  • FDA: binds many other drugs and cuts their absorption
  • FDA: chronic renal failure — aluminium can build up
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered locally, not re-fetched) · read 2026-08-27
    what it says
    “One registered sucralfate product, Forensicclassification 'Prescription Only' — SIN08585P APO-SUCRALFATE TABLET 1 g, Licenseholder PHARMAFORTE SINGAPORE PTE LTD (ATC A02BX02, dosage form TABLET). No General Sale List or Pharmacy Only sucralfate row exists.”
  2. Singapore National Drug Formulary — APO-SUCRALFATE TABLET 1 G [SIN08585P], Product Info (no indication or dosing sections published) · read 2026-08-27
    what it says
    “APO-SUCRALFATE TABLET 1 G [SIN08585P] … Active Ingredient and Strength SUCRALFATE - 1 G … Forensic Classification PRESCRIPTION ONLY MEDICINES … Anatomical Therapeutic Chemical (ATC) code A02BX02”
  3. HealthHub (Pharmaceutical Society of Singapore) — Sucralfate: what is this medication for · read 2026-08-27
    what it says
    “The medication is used for the treatment and prevention of ulcers in the gastrointestinal tract.”
  4. HealthHub — Sucralfate: how should I take or use this medication · read 2026-08-27
    what it says
    “Do not stop taking your medication without checking with your healthcare professional. This medication should be taken half to one hour before food.”
  5. HealthHub — Sucralfate: what precautions should I take · read 2026-08-27
    what it says
    “Inform your healthcare professional if: You are allergic to this medication … You are pregnant, planning to become pregnant or breastfeeding. You are taking any other medications, including supplements, traditional medications and herbal remedies.”
  6. HealthHub — Sucralfate: what food or medication should I avoid · read 2026-08-27
    what it says
    “This drug commonly affects the effect of other drugs administered at the same time. Space at least 2 hours apart from other medications … alendronate/risedronate, certain heart medications, medications for the treatment of human immunodeficiency virus (HIV) and warfarin.”
  7. US FDA label for CARAFATE (sucralfate) Oral Suspension, Indications and Usage, via openFDA drug/label.json (effective 2023-06-08) · read 2026-08-27
    what it says
    “CARAFATE (sucralfate) Oral Suspension is indicated in the short-term (up to 8 weeks) treatment of active duodenal ulcer.”
  8. US FDA label for CARAFATE, Dosage and Administration, via openFDA · read 2026-08-27
    what it says
    “The recommended adult oral dosage for duodenal ulcer is 1 gram (10 mL) four times per day. CARAFATE Oral Suspension should be administered on an empty stomach. Antacids … should not be taken within one-half hour before or after”
  9. US FDA label for CARAFATE, Adverse Reactions, via openFDA · read 2026-08-27
    what it says
    “In studies involving over 2700 patients treated with sucralfate, adverse effects were reported in 129 (4.7%). Constipation was the most frequent complaint (2%) … Bezoars have been reported in patients treated with sucralfate.”
  10. US FDA label for CARAFATE, Drug Interactions, via openFDA · read 2026-08-27
    what it says
    “simultaneous sucralfate administration … reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline … dosing the concomitant medication 2 hours before sucralfate eliminated the interaction”
  11. US FDA label for CARAFATE, Precautions — Chronic Renal Failure and Dialysis Patients, via openFDA · read 2026-08-27
    what it says
    “Aluminum accumulation and toxicity (aluminum osteodystrophy, osteomalacia, encephalopathy) have been described in patients with renal impairment. Sucralfate should be used with caution in patients with chronic renal failure … Episodes of hyperglycemia have been reported in diabetic patients.”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.