{"ok":true,"entry":{"slug":"sucralfate","kind":"medication","name":"sucralfate","aliases":["Ulsanic","Carafate"],"brands_sg":["Apo-Sucralfate"],"class":"mucosal protectant","tags":["digestive"],"use_for":"prescribed for ulcers in the gut lining","use_after":"healthhub: half to one hour before food","use_duration":null,"take_with":"water on an empty stomach · 2 h from other medicines","pros":["healthhub: treats and prevents ulcers in the gut","fda: adverse effects in 129 of 2,700+ patients (4.7%)","fda: other drugs 2 h earlier ends the interaction"],"cons":["fda: constipation was the most frequent complaint (2%)","fda: binds many other drugs and cuts their absorption","fda: chronic renal failure — aluminium can build up"],"dose_note":"no singapore package insert for sucralfate is published on the national drug formulary and healthhub gives no number, so the nearest label maximum read was the us fda label for carafate (sucralfate) oral suspension: “the recommended adult oral dosage for duodenal ulcer is 1 gram (10 mL) four times per day”, “administered on an empty stomach”, for “the short-term (up to 8 weeks) treatment of active duodenal ulcer”; that label also says antacids “should not be taken within one-half hour before or after” it. the single sucralfate product on the sg register is apo-sucralfate 1 g tablet. in singapore this is prescription-only and the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["chronic renal failure or dialysis — fda: aluminium accumulation and toxicity described","diabetes — fda: hyperglycaemia reported; close monitoring of glycaemia recommended","delayed gastric emptying or tube feeding — fda: bezoars have been reported","pregnant, planning pregnancy or breastfeeding — healthhub: inform your healthcare professional"],"clashes":[{"src":["fda_carafate_di"],"note":"fda: simultaneous sucralfate reduced the extent of absorption of single doses","with":"levothyroxine, digoxin, phenytoin, quinidine, theophylline"},{"src":["fda_carafate_di"],"note":"fda: absorption reduced; dosing them 2 hours before sucralfate eliminated the interaction","with":"fluoroquinolone antibiotics (ciprofloxacin, norfloxacin, ofloxacin)"},{"src":["fda_carafate_di"],"note":"fda: subtherapeutic prothrombin times reported in case reports, though two clinical studies showed no change","with":"warfarin"},{"src":["fda_carafate_dose","fda_carafate_renal"],"note":"fda: not within half an hour before or after; may raise total body aluminium burden","with":"antacids and other aluminium-containing products"},{"src":["hh_sucralfate_avoid"],"note":"healthhub: space at least 2 hours apart from other medications","with":"alendronate, risedronate and hiv medicines"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered locally, not re-fetched)","quote":"One registered sucralfate product, Forensicclassification 'Prescription Only' — SIN08585P APO-SUCRALFATE TABLET 1 g, Licenseholder PHARMAFORTE SINGAPORE PTE LTD (ATC A02BX02, dosage form TABLET). No General Sale List or Pharmacy Only sucralfate row exists.","accessed":"2026-08-27"},{"id":"ndf_sucralfate","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin08585p/","label":"Singapore National Drug Formulary — APO-SUCRALFATE TABLET 1 G [SIN08585P], Product Info (no indication or dosing sections published)","quote":"APO-SUCRALFATE TABLET 1 G [SIN08585P] … Active Ingredient and Strength SUCRALFATE - 1 G … Forensic Classification PRESCRIPTION ONLY MEDICINES … Anatomical Therapeutic Chemical (ATC) code A02BX02","accessed":"2026-08-27"},{"id":"hh_sucralfate_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/sucralfate","label":"HealthHub (Pharmaceutical Society of Singapore) — Sucralfate: what is this medication for","quote":"The medication is used for the treatment and prevention of ulcers in the gastrointestinal tract.","accessed":"2026-08-27"},{"id":"hh_sucralfate_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/sucralfate","label":"HealthHub — Sucralfate: how should I take or use this medication","quote":"Do not stop taking your medication without checking with your healthcare professional. This medication should be taken half to one hour before food.","accessed":"2026-08-27"},{"id":"hh_sucralfate_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/sucralfate","label":"HealthHub — Sucralfate: what precautions should I take","quote":"Inform your healthcare professional if: You are allergic to this medication … You are pregnant, planning to become pregnant or breastfeeding. You are taking any other medications, including supplements, traditional medications and herbal remedies.","accessed":"2026-08-27"},{"id":"hh_sucralfate_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/sucralfate","label":"HealthHub — Sucralfate: what food or medication should I avoid","quote":"This drug commonly affects the effect of other drugs administered at the same time. Space at least 2 hours apart from other medications … alendronate/risedronate, certain heart medications, medications for the treatment of human immunodeficiency virus (HIV) and warfarin.","accessed":"2026-08-27"},{"id":"fda_carafate_ind","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22CARAFATE%22&limit=1","label":"US FDA label for CARAFATE (sucralfate) Oral Suspension, Indications and Usage, via openFDA drug/label.json (effective 2023-06-08)","quote":"CARAFATE (sucralfate) Oral Suspension is indicated in the short-term (up to 8 weeks) treatment of active duodenal ulcer.","accessed":"2026-08-27"},{"id":"fda_carafate_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22CARAFATE%22&limit=1","label":"US FDA label for CARAFATE, Dosage and Administration, via openFDA","quote":"The recommended adult oral dosage for duodenal ulcer is 1 gram (10 mL) four times per day. CARAFATE Oral Suspension should be administered on an empty stomach. Antacids … should not be taken within one-half hour before or after","accessed":"2026-08-27"},{"id":"fda_carafate_ar","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22CARAFATE%22&limit=1","label":"US FDA label for CARAFATE, Adverse Reactions, via openFDA","quote":"In studies involving over 2700 patients treated with sucralfate, adverse effects were reported in 129 (4.7%). Constipation was the most frequent complaint (2%) … Bezoars have been reported in patients treated with sucralfate.","accessed":"2026-08-27"},{"id":"fda_carafate_di","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22CARAFATE%22&limit=1","label":"US FDA label for CARAFATE, Drug Interactions, via openFDA","quote":"simultaneous sucralfate administration … reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline … dosing the concomitant medication 2 hours before sucralfate eliminated the interaction","accessed":"2026-08-27"},{"id":"fda_carafate_renal","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22CARAFATE%22&limit=1","label":"US FDA label for CARAFATE, Precautions — Chronic Renal Failure and Dialysis Patients, via openFDA","quote":"Aluminum accumulation and toxicity (aluminum osteodystrophy, osteomalacia, encephalopathy) have been described in patients with renal impairment. Sucralfate should be used with caution in patients with chronic renal failure … Episodes of hyperglycemia have been reported in diabetic patients.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:31.341231+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}