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Squalene

Supplement lipid skin & hairimmune
Aka: shark liver oil, squalane
Brands seen in Singapore: Mild By Nature, Vanicream, Advanced Clinicals, Pura D'or, Missha
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
A sebum lipid; SG listings are topical squalane skincare
Pros & cons
Pros
  • A normal component of human sebum
  • The body makes it, so toxicity potential is low
  • Mf59 squalene adjuvant: safety well characterised
Cons
  • SG listings are skincare, not oral supplements
  • Myalgia rose slightly with the mf59 adjuvant (rr 1.35)
  • Not in HSA's annex a/b — that list is not exhaustive
Sources
  1. The heterogeneity and complexity of skin surface lipids in human skin health and disease (Mijaljica et al., Prog Lipid Res 2024) — abstract via Europe PMC · read 2026-08-27
    what it says
    “sebum is a waxy mixture predominantly composed of acylglycerols, wax esters, non-esterified fatty acids, squalene, cholesterol and cholesterol esters”
  2. Systematic Review of Safety of MF59-Adjuvanted Influenza Vaccine in Older Adults (2026) — why squalene was chosen · read 2026-08-27
    what it says
    “Squalene was chosen as the base for this adjuvant because it is a naturally occurring oil synthesized by humans and, therefore, offers low toxicity potential”
  3. Systematic Review of Safety of MF59-Adjuvanted Influenza Vaccine in Older Adults (2026) — conclusion · read 2026-08-27
    what it says
    “MF59-adjuvanted influenza vaccines have a favorable and well-characterized safety profile in adults aged 60 years and older. Adverse events are predominantly mild and transient”
  4. Systematic Review of Safety of MF59-Adjuvanted Influenza Vaccine in Older Adults (2026) — the one signal found · read 2026-08-27
    what it says
    “only myalgia showed a small but significant increase with adjuvanted vaccines (RR 1.35, 95% CI 1.02–1.78) compared with non-adjuvanted vaccines”
  5. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev 001 (Oct 2025), Annex A/B — searched, no row for this ingredient · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  6. iHerb Singapore — Squalane category (default order, 1 - 36 of 36 results); sg.iherb.com/c/squalene and /c/shark-liver-oil both return 404, so this topical category is the only matching one · read 2026-08-27
    what it says
    “Mild By Nature, All Day Hydration Cream … Vanicream, Daily Facial Moisturizer … Advanced Clinicals, Hyaluronic Acid Hydrating Body Cream … Pura D'or, Squalane Oil … Missha, M B.B Boomer”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.