← All supplements

Spermidine

Supplement polyamine general nutrition
Aka: wheat germ spermidine
Brands seen in Singapore: California Gold Nutrition, Probase Nutrition, Neurogan Health, Force Factor, ProHealth Longevity
Third-party tested: Force Factor certifies other products with NSF Certified for Sport, but nothing for spermidine.Certification is granted per product, so check the tub you actually own. Not being listed is not the same as failing.
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Limited human evidence — a 40-person pilot in older adults
Pros & cons
Pros
  • A pilot RCT used 6 mg a day for 13 weeks
  • Not named in HSA's prohibited or restricted annexes
Cons
  • Human evidence is limited and largely inconclusive
  • Benefit appeared only in vaccine non-responders
  • No RDA, no upper limit, no SG cap set
Sources
  1. Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults — A Pilot Study (Aging Cell 2026) · read 2026-08-27
    what it says
    “We conducted a double-blind, randomised, placebo-controlled pilot study in 40 adults over 65 years of age … Daily oral supplementation (6 mg, 13 weeks) was well-tolerated … specifically in non-responders”
  2. Spermidine in Alzheimer's Disease: Evidence from Animal Models and Human Studies (Degener Neurol Neuromuscul Dis 2026) · read 2026-08-27
    what it says
    “human clinical evidence remains limited and largely inconclusive. Observational studies suggest associations between higher dietary spermidine intake and better cognitive outcomes, but do not establish causality”
  3. HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annexes A and B · read 2026-08-27
    what it says
    “Annex A: List of substances which are prohibited or restricted for use with conditions … Annex B: List of substances with potential safety issues [spermidine appears in neither annex]”
  4. HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits · read 2026-08-27
    what it says
    “Table 4: Vitamins Limits … Table 5: Minerals Limits [neither table names spermidine]”
  5. iHerb Singapore — Spermidine category page, default order · read 2026-08-27
    what it says
    “California Gold Nutrition, Spermidine, Rice Germ Extract … Probase Nutrition, Spermidine, 10 mg, 120 Capsules … Neurogan Health, Spermidine, 10 mg, 120 Tablets … Force Factor, Spermidine, 120 Vegetable Capsules … ProHealth Longevity, Pure Spermidine, 1 mg”
Report a correction View as JSON

Updated 2026-08-30. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.