{"ok":true,"entry":{"slug":"spermidine","kind":"supplement","name":"spermidine","aliases":["wheat germ spermidine"],"brands_sg":["California Gold Nutrition","Probase Nutrition","Neurogan Health","Force Factor","ProHealth Longevity"],"class":"polyamine","tags":["general"],"use_for":"limited human evidence — a 40-person pilot in older adults","use_after":null,"use_duration":null,"take_with":null,"pros":["a pilot RCT used 6 mg a day for 13 weeks","not named in HSA's prohibited or restricted annexes"],"cons":["human evidence is limited and largely inconclusive","benefit appeared only in vaccine non-responders","no RDA, no upper limit, no SG cap set"],"dose_note":"a double-blind placebo-controlled pilot in 40 adults over 65 used 6 mg a day for 13 weeks; no standard dose is settled","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["the only human dose anchor is one 40-person pilot in over-65s","no upper limit set — absence of a cap is not safety"],"clashes":[],"sources":[{"id":"sperm_pilot","url":"https://europepmc.org/article/PMC/PMC13240347","label":"Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults — A Pilot Study (Aging Cell 2026)","quote":"We conducted a double-blind, randomised, placebo-controlled pilot study in 40 adults over 65 years of age … Daily oral supplementation (6 mg, 13 weeks) was well-tolerated … specifically in non-responders","accessed":"2026-08-27"},{"id":"sperm_review","url":"https://europepmc.org/article/PMC/PMC13292852","label":"Spermidine in Alzheimer's Disease: Evidence from Animal Models and Human Studies (Degener Neurol Neuromuscul Dis 2026)","quote":"human clinical evidence remains limited and largely inconclusive. Observational studies suggest associations between higher dietary spermidine intake and better cognitive outcomes, but do not establish causality","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annexes A and B","quote":"Annex A: List of substances which are prohibited or restricted for use with conditions … Annex B: List of substances with potential safety issues [spermidine appears in neither annex]","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits","quote":"Table 4: Vitamins Limits … Table 5: Minerals Limits [neither table names spermidine]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/spermidine","label":"iHerb Singapore — Spermidine category page, default order","quote":"California Gold Nutrition, Spermidine, Rice Germ Extract … Probase Nutrition, Spermidine, 10 mg, 120 Capsules … Neurogan Health, Spermidine, 10 mg, 120 Tablets … Force Factor, Spermidine, 120 Vegetable Capsules … ProHealth Longevity, Pure Spermidine, 1 mg","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Force Factor","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":6}],"updated_at":"2026-08-30T17:59:38.376296+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}