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Serrapeptase

Supplement proteolytic enzyme bone & jointgeneral nutrition
Aka: serratiopeptidase
Brands seen in Singapore: California Gold Nutrition, Nutricost, Doctor's Best, Vitamatic, Enzymedica
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Swelling and pain claims — limited human evidence
Pros & cons
Pros
  • A dental meta-analysis found less trismus after surgery
Cons
  • Evidence insufficient to support use as a supplement
  • Long-term safety data is lacking
  • No swelling benefit vs steroids in one meta-analysis
Sources
  1. Serratiopeptidase: a systematic review of the existing evidence (Bhagat et al., Int J Surg 2013) · read 2026-08-27
    what it says
    “The existing scientific evidence for Serratiopeptidase is insufficient to support its use as an analgesic and health supplement. The data on long-term safety of this enzyme is lacking.”
  2. Serratiopeptidase systematic review (Bhagat 2013) — evidence synthesis · read 2026-08-27
    what it says
    “based on clinical studies which are of poor methodology. Only few RCTs, which are usually placebo control, with a small sample size are there. The dose and duration of treatment was not specified in some studies”
  3. Role of Serratiopeptidase After Surgical Removal of Impacted Molar: A Systematic Review and Meta-analysis (J Maxillofac Oral Surg 2018) · read 2026-08-27
    what it says
    “Five studies were included for final review. Serratiopeptidase improved trismus better than corticosteroids … As regards to swelling, no significant difference was observed for serratiopeptidase when compared to corticosteroids”
  4. HSA Guidelines on prohibited and restricted ingredients in HS and TM (GL-CHPB-1-012, Oct 2025), s1.3 / Annex A · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  5. HSA Health Supplements Guidelines (GL-CHPB-3-001 Rev. 020, Jan 2026), s8.1 · read 2026-08-27
    what it says
    “Currently, HS are not subject to premarket approval and licensing by HSA for their importation, manufacture and sales in Singapore.”
  6. iHerb Singapore — Serrapeptase category (default best-selling order) · read 2026-08-27
    what it says
    “California Gold Nutrition … Nutricost … Doctor's Best … Vitamatic … Enzymedica”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.