{"ok":true,"entry":{"slug":"serrapeptase","kind":"supplement","name":"serrapeptase","aliases":["serratiopeptidase"],"brands_sg":["California Gold Nutrition","Nutricost","Doctor's Best","Vitamatic","Enzymedica"],"class":"proteolytic enzyme","tags":["bone-joint","general"],"use_for":"swelling and pain claims — limited human evidence","use_after":null,"use_duration":null,"take_with":null,"pros":["a dental meta-analysis found less trismus after surgery"],"cons":["evidence insufficient to support use as a supplement","long-term safety data is lacking","no swelling benefit vs steroids in one meta-analysis"],"dose_note":"a systematic review found dose and duration were not specified in some of the studies it graded","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["long-term safety data is lacking — a 2013 systematic review flagged this","supporting trials were small and of poor methodology","not named in hsa's prohibited/restricted annex — that list is not exhaustive, so it is not a safety clearance","hsa does not approve health supplements before sale in singapore"],"clashes":[],"sources":[{"id":"bhagat2013","url":"https://europepmc.org/article/MED/23380245","label":"Serratiopeptidase: a systematic review of the existing evidence (Bhagat et al., Int J Surg 2013)","quote":"The existing scientific evidence for Serratiopeptidase is insufficient to support its use as an analgesic and health supplement. The data on long-term safety of this enzyme is lacking.","accessed":"2026-08-27"},{"id":"bhagat2013_meth","url":"https://europepmc.org/article/MED/23380245","label":"Serratiopeptidase systematic review (Bhagat 2013) — evidence synthesis","quote":"based on clinical studies which are of poor methodology. Only few RCTs, which are usually placebo control, with a small sample size are there. The dose and duration of treatment was not specified in some studies","accessed":"2026-08-27"},{"id":"rao2018","url":"https://europepmc.org/article/PMC/PMC5878179","label":"Role of Serratiopeptidase After Surgical Removal of Impacted Molar: A Systematic Review and Meta-analysis (J Maxillofac Oral Surg 2018)","quote":"Five studies were included for final review. Serratiopeptidase improved trismus better than corticosteroids … As regards to swelling, no significant difference was observed for serratiopeptidase when compared to corticosteroids","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Guidelines on prohibited and restricted ingredients in HS and TM (GL-CHPB-1-012, Oct 2025), s1.3 / Annex A","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Health Supplements Guidelines (GL-CHPB-3-001 Rev. 020, Jan 2026), s8.1","quote":"Currently, HS are not subject to premarket approval and licensing by HSA for their importation, manufacture and sales in Singapore.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/serrapeptase","label":"iHerb Singapore — Serrapeptase category (default best-selling order)","quote":"California Gold Nutrition … Nutricost … Doctor's Best … Vitamatic … Enzymedica","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:31.341231+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}