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Salicylic acid

Medication keratolytic skin
Aka: Duofilm, BHA, beta hydroxy acid
Brands seen in Singapore: Collomack, Duofilm, ICM White Spot Lotion, Nixoderm, Sato Uonome
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Removal of common warts, and of corns and calluses
When to take
On an area washed and dried first, per the US otc label
Take with
External use only · not on face, moles or genital warts
Pros & cons
Pros
  • Cochrane 2012: rr 1.56 vs placebo for wart clearance
  • General sale list in SG — 17 of 22 registrations
  • Cochrane: no clear difference vs cryotherapy
Cons
  • Cochrane: many trials at high risk of bias
  • US otc label caps a wart course at 12 weeks
  • Not for diabetes or poor circulation, per the label
Sources
  1. MOH National Drug Formulary — COLLOMACK SALICYLIC ACID SOLUTION 10% [SIN13728P], product information (page last updated 28 Jul 2026) · read 2026-08-27
    what it says
    “Active Ingredient and Strength SALICYLIC ACID - 100 MG … Dosage Form SOLUTION … Forensic Classification GENERAL SALE LIST … Anatomical Therapeutic Chemical (ATC) code D01AE12”
  2. MOH National Drug Formulary — SALICYLIC ACID 2% CREAM [SIN02882P], product information · read 2026-08-27
    what it says
    “SALICYLIC ACID 2% CREAM [SIN02882P] … Forensic Classification GENERAL SALE LIST”
  3. MOH National Drug Formulary — DUOFILM COLLODION [SIN04047P], product information · read 2026-08-27
    what it says
    “Active ingredients: LACTIC ACID 16.7% EQUIVALENT TO LACTIC ACID ANHYDROUS | SALICYLIC ACID … SALICYLIC ACID - 16.7% … Forensic Classification GENERAL SALE LIST”
  4. US FDA OTC monograph — 21 CFR 358.150, Labeling of wart remover drug products (indications, warnings, directions) · read 2026-08-27
    what it says
    “For the removal of common warts … Wash affected area … Dry area thoroughly. Apply one drop at a time … Repeat this procedure once or twice daily as needed (until wart is removed) for up to 12 weeks … Do not use this product on irritated skin, on any area that is infected or reddened, if you are a diabetic, or if you have poor blood circulation”
  5. US FDA OTC monograph — 21 CFR 358.550, Labeling of corn and callus remover drug products (directions) · read 2026-08-27
    what it says
    “Wash affected area and dry thoroughly. Apply one drop at a time with applicator to sufficiently cover each corn/callus. Let dry. Repeat this procedure once or twice daily as needed for up to 14 days (until corn/callus is removed).”
  6. Cochrane Database of Systematic Reviews — Topical treatments for cutaneous warts (Kwok, Gibbs, Bennett, Holland, Abbott 2012; PMC8101088) · read 2026-08-27
    what it says
    “Trials of salicylic acid (SA) versus placebo showed that the former significantly increased the chance of clearance of warts at all sites (RR 1.56, 95% CI 1.20 to 2.03) … Meta-analysis did not demonstrate a significant difference in effectiveness between cryotherapy and SA at all sites … Many of the studies were judged to be at high risk of bias”
  7. HSA register of therapeutic products (data.gov.sg d_767279312753558cbf19d48344577084) — 22 salicylic-acid rows (acetylsalicylic acid excluded), filtered locally from the cached copy on 27 Aug 26 · read 2026-08-27
    what it says
    “SALICYLIC ACID 2% CREAM … General Sale List … Collomack Salicylic Acid Solution 10% … General Sale List … ICM WHITE SPOT LOTION 5% … General Sale List … DUOFILM COLLODION … General Sale List … BEPROSALIC OINTMENT … Prescription Only … VERRUMAL SOLUTION … Prescription Only”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.