{"ok":true,"entry":{"slug":"salicylic-acid","kind":"medication","name":"salicylic acid","aliases":["Duofilm","BHA","beta hydroxy acid"],"brands_sg":["Collomack","Duofilm","ICM White Spot Lotion","Nixoderm","Sato Uonome"],"class":"keratolytic","tags":["skin"],"use_for":"removal of common warts, and of corns and calluses","use_after":"on an area washed and dried first, per the us otc label","use_duration":null,"take_with":"external use only · not on face, moles or genital warts","pros":["cochrane 2012: rr 1.56 vs placebo for wart clearance","general sale list in sg — 17 of 22 registrations","cochrane: no clear difference vs cryotherapy"],"cons":["cochrane: many trials at high risk of bias","us otc label caps a wart course at 12 weeks","not for diabetes or poor circulation, per the label"],"dose_note":"no singapore salicylic acid registration publishes a dosing section — the ndf pages for Collomack Salicylic Acid Solution 10% [SIN13728P], SALICYLIC ACID 2% CREAM [SIN02882P] and DUOFILM COLLODION [SIN04047P] each show product information only. the nearest stated label maximum is the us otc monograph: for wart removers 21 CFR 358.150(d)(2) requires the directions to read 'repeat this procedure once or twice daily as needed (until wart is removed) for up to 12 weeks', and for corn and callus removers 21 CFR 358.550(d)(2) reads 'repeat this procedure once or twice daily as needed for up to 14 days (until corn/callus is removed)' — once or twice a day, with a 12-week (wart) or 14-day (corn/callus) ceiling, is the largest amount those labels state; as directed on the label or by your pharmacist or doctor","dosage":null,"ul_status":null,"sg_class":"general-sale","cautions":["diabetes or poor blood circulation — the us otc label says not to use it","irritated, infected or reddened skin — the us otc label says not to use it","moles, birthmarks, hairy warts, genital warts, the face or mucous membranes — excluded by the label","the sg combination products add a steroid or fluorouracil and are prescription only"],"clashes":[{"src":["ndf_collomack","ndf_duofilm","ndf_sa_cream"],"note":"the ndf pages for Collomack, Duofilm and Salicylic Acid 2% Cream publish no interaction section — untested, not shown safe","with":"nothing documented on the sg registrations"},{"src":["hsa_register_sa"],"note":"the 5 prescription-only sg rows are all salicylic acid combined with a corticosteroid or with fluorouracil, which is what makes them prescription-only","with":"betamethasone or fluorouracil in the same product"}],"sources":[{"id":"ndf_collomack","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13728p/","label":"MOH National Drug Formulary — COLLOMACK SALICYLIC ACID SOLUTION 10% [SIN13728P], product information (page last updated 28 Jul 2026)","quote":"Active Ingredient and Strength SALICYLIC ACID - 100 MG … Dosage Form SOLUTION … Forensic Classification GENERAL SALE LIST … Anatomical Therapeutic Chemical (ATC) code D01AE12","accessed":"2026-08-27"},{"id":"ndf_sa_cream","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02882p/","label":"MOH National Drug Formulary — SALICYLIC ACID 2% CREAM [SIN02882P], product information","quote":"SALICYLIC ACID 2% CREAM [SIN02882P] … Forensic Classification GENERAL SALE LIST","accessed":"2026-08-27"},{"id":"ndf_duofilm","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin04047p/","label":"MOH National Drug Formulary — DUOFILM COLLODION [SIN04047P], product information","quote":"Active ingredients: LACTIC ACID 16.7% EQUIVALENT TO LACTIC ACID ANHYDROUS | SALICYLIC ACID … SALICYLIC ACID - 16.7% … Forensic Classification GENERAL SALE LIST","accessed":"2026-08-27"},{"id":"ecfr_wart","url":"https://www.ecfr.gov/current/title-21/chapter-I/subchapter-D/part-358/subpart-B/section-358.150","label":"US FDA OTC monograph — 21 CFR 358.150, Labeling of wart remover drug products (indications, warnings, directions)","quote":"For the removal of common warts … Wash affected area … Dry area thoroughly. Apply one drop at a time … Repeat this procedure once or twice daily as needed (until wart is removed) for up to 12 weeks … Do not use this product on irritated skin, on any area that is infected or reddened, if you are a diabetic, or if you have poor blood circulation","accessed":"2026-08-27"},{"id":"ecfr_corn","url":"https://www.ecfr.gov/current/title-21/chapter-I/subchapter-D/part-358/subpart-F/section-358.550","label":"US FDA OTC monograph — 21 CFR 358.550, Labeling of corn and callus remover drug products (directions)","quote":"Wash affected area and dry thoroughly. Apply one drop at a time with applicator to sufficiently cover each corn/callus. Let dry. Repeat this procedure once or twice daily as needed for up to 14 days (until corn/callus is removed).","accessed":"2026-08-27"},{"id":"cochrane_warts2012","url":"https://europepmc.org/article/PMC/PMC8101088","label":"Cochrane Database of Systematic Reviews — Topical treatments for cutaneous warts (Kwok, Gibbs, Bennett, Holland, Abbott 2012; PMC8101088)","quote":"Trials of salicylic acid (SA) versus placebo showed that the former significantly increased the chance of clearance of warts at all sites (RR 1.56, 95% CI 1.20 to 2.03) … Meta-analysis did not demonstrate a significant difference in effectiveness between cryotherapy and SA at all sites … Many of the studies were judged to be at high risk of bias","accessed":"2026-08-27"},{"id":"hsa_register_sa","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA register of therapeutic products (data.gov.sg d_767279312753558cbf19d48344577084) — 22 salicylic-acid rows (acetylsalicylic acid excluded), filtered locally from the cached copy on 27 Aug 26","quote":"SALICYLIC ACID 2% CREAM … General Sale List … Collomack Salicylic Acid Solution 10% … General Sale List … ICM WHITE SPOT LOTION 5% … General Sale List … DUOFILM COLLODION … General Sale List … BEPROSALIC OINTMENT … Prescription Only … VERRUMAL SOLUTION … Prescription Only","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:31.341231+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}