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Royal jelly

Supplement bee product energywomen's health
Aka: 10-HDA, gelee royale
Brands seen in Singapore: California Gold Nutrition, NOW Foods, Imperial Elixir, Honey Gardens, Swanson Vitamins
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Menopausal symptoms in one RCT · strength trial null
When to take
Daily
Take with
Water · trials used capsules or tablets, not raw jelly
Studied for
Trials ran from 8 weeks to 12 months
Pros & cons
Pros
  • 8-week RCT, 1,000 mg: menopausal score fell
  • 12-month trial: no treatment-related adverse events
  • 10-hda is the marker fatty acid used on labels
Cons
  • Asthma and anaphylaxis reported after eating it
  • 12-month trial found no gain in physical performance
  • Composition varies with bee species, diet and season
Sources
  1. Effect of royal jelly on menopausal symptoms: A randomized placebo-controlled clinical trial (Sharif & Darsareh, Complement Ther Clin Pract 2019) · read 2026-08-27
    what it says
    “Each participant received either 1000 mg of royal jelly capsules or placebo daily for eight weeks … The menopausal score reduced significantly after eight weeks of intervention in experimental group … However, further research is necessary to confirm the effects”
  2. Effects of protease-treated royal jelly on muscle strength in elderly nursing home residents: A randomized, double-blind, placebo-controlled trial (Meng et al., Scientific Reports 2017) · read 2026-08-27
    what it says
    “the results of this 12-month trial showed that pRJ treatment might not improve, but rather attenuate the progression of decrease in muscle strength in elderly people … we have not found that pRJ intervention can achieve improvement … in physical performance”
  3. Meng et al., Scientific Reports 2017 — tolerability over 12 months · read 2026-08-27
    what it says
    “Both the intervention and placebo groups were tolerated well by the study participants, and no treatment related adverse events occurred”
  4. Meng et al., Scientific Reports 2017 — tablet strength · read 2026-08-27
    what it says
    “Table 2 shows the components included in the placebo and pRJ tablets (400 mg pRJ per tablet)”
  5. Asthma and anaphylaxis induced by royal jelly (Thien et al., Clinical and Experimental Allergy 1996) · read 2026-08-27
    what it says
    “Asthma, together with, in some cases, anaphylaxis, was observed in seven subjects following ingestion of royal jelly … Symptoms of asthma and anaphylaxis seen in subjects following ingestion of royal jelly were true IgE-mediated hypersensitivity reactions”
  6. Thien et al., Clin Exp Allergy 1996 — cross-reactivity in allergic controls · read 2026-08-27
    what it says
    “Examination of 63 sera from subjects allergic to bee venom showed … 38% of the sera reacted with a royal jelly solid phase. IgE antibody reactivity to royal jelly proteins was also detected in 52% of 75 subjects with allergies”
  7. Royal jelly a promising therapeutic intervention and functional food supplement: A systematic review (Kumar et al., Heliyon 2024) — composition · read 2026-08-27
    what it says
    “RJ is an acidic secretion with a pH of 3.5–4.2. It mostly consists of water 60–70 %, sugars 7–18 %, proteins 9–18 %, lipids 3–8%, minerals … Major lipids in it consist of 10-hydroxy-2-decanoic acid and sebacic acid”
  8. Kumar et al., Heliyon 2024 — limitations of the evidence base · read 2026-08-27
    what it says
    “Variability in the composition of RJ due to differences in bee species, diet, and environmental factors poses challenges in standardizing dosages and formulations. Lastly, the limited number of large-scale, well-controlled clinical trials restricts the ability to draw definitive conclusions”
  9. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev 001 (Oct 2025) · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [royal jelly / 10-HDA not listed in Annex A or B]”
  10. HSA — Health Supplements Guidelines (Jan 2026), clause 4.8 and Tables 4–5 (vitamins and minerals limits) · read 2026-08-27
    what it says
    “HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5”
  11. iHerb Singapore — Royal Jelly category (default order) · read 2026-08-27
    what it says
    “California Gold Nutrition, Royal Jelly, 500 mg … NOW Foods, Royal Jelly, 60 Capsules (500 mg per Capsule) … Imperial Elixir, Ginseng and Royal Jelly … Honey Gardens, Royal Jelly, In Raw Honey … Swanson Vitamins, Royal Jelly, 100 Softgels”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.