{"ok":true,"entry":{"slug":"royal-jelly","kind":"supplement","name":"royal jelly","aliases":["10-HDA","gelee royale"],"brands_sg":["California Gold Nutrition","NOW Foods","Imperial Elixir","Honey Gardens","Swanson Vitamins"],"class":"bee product","tags":["energy","womens-health"],"use_for":"menopausal symptoms in one rct · strength trial null","use_after":"daily","use_duration":"trials ran from 8 weeks to 12 months","take_with":"water · trials used capsules or tablets, not raw jelly","pros":["8-week rct, 1,000 mg: menopausal score fell","12-month trial: no treatment-related adverse events","10-hda is the marker fatty acid used on labels"],"cons":["asthma and anaphylaxis reported after eating it","12-month trial found no gain in physical performance","composition varies with bee species, diet and season"],"dose_note":"the menopause trial gave 1,000 mg a day of royal jelly capsules to 200 postmenopausal women for 8 weeks and says further research is needed; the 12-month trial in elderly nursing-home residents used protease-treated royal jelly tablets of 400 mg each; the 2024 review says few large, well-controlled trials exist and that composition is hard to standardise","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["asthma — ige-mediated asthma and anaphylaxis are documented","allergy to inhalants or foods — half of such sera bound royal jelly proteins","bee-venom allergy — a third of those sera also reacted to royal jelly","pregnancy or breastfeeding — no trial data in the sources read"],"clashes":[],"sources":[{"id":"sharif2019","url":"https://europepmc.org/article/MED/31470366","label":"Effect of royal jelly on menopausal symptoms: A randomized placebo-controlled clinical trial (Sharif & Darsareh, Complement Ther Clin Pract 2019)","quote":"Each participant received either 1000 mg of royal jelly capsules or placebo daily for eight weeks … The menopausal score reduced significantly after eight weeks of intervention in experimental group … However, further research is necessary to confirm the effects","accessed":"2026-08-27"},{"id":"meng2017","url":"https://europepmc.org/article/PMC/PMC5595990","label":"Effects of protease-treated royal jelly on muscle strength in elderly nursing home residents: A randomized, double-blind, placebo-controlled trial (Meng et al., Scientific Reports 2017)","quote":"the results of this 12-month trial showed that pRJ treatment might not improve, but rather attenuate the progression of decrease in muscle strength in elderly people … we have not found that pRJ intervention can achieve improvement … in physical performance","accessed":"2026-08-27"},{"id":"meng2017_safety","url":"https://europepmc.org/article/PMC/PMC5595990","label":"Meng et al., Scientific Reports 2017 — tolerability over 12 months","quote":"Both the intervention and placebo groups were tolerated well by the study participants, and no treatment related adverse events occurred","accessed":"2026-08-27"},{"id":"meng2017_dose","url":"https://europepmc.org/article/PMC/PMC5595990","label":"Meng et al., Scientific Reports 2017 — tablet strength","quote":"Table 2 shows the components included in the placebo and pRJ tablets (400 mg pRJ per tablet)","accessed":"2026-08-27"},{"id":"thien1996","url":"https://europepmc.org/article/MED/8835130","label":"Asthma and anaphylaxis induced by royal jelly (Thien et al., Clinical and Experimental Allergy 1996)","quote":"Asthma, together with, in some cases, anaphylaxis, was observed in seven subjects following ingestion of royal jelly … Symptoms of asthma and anaphylaxis seen in subjects following ingestion of royal jelly were true IgE-mediated hypersensitivity reactions","accessed":"2026-08-27"},{"id":"thien1996_cross","url":"https://europepmc.org/article/MED/8835130","label":"Thien et al., Clin Exp Allergy 1996 — cross-reactivity in allergic controls","quote":"Examination of 63 sera from subjects allergic to bee venom showed … 38% of the sera reacted with a royal jelly solid phase. IgE antibody reactivity to royal jelly proteins was also detected in 52% of 75 subjects with allergies","accessed":"2026-08-27"},{"id":"kumar2024_composition","url":"https://europepmc.org/article/PMC/PMC11408027","label":"Royal jelly a promising therapeutic intervention and functional food supplement: A systematic review (Kumar et al., Heliyon 2024) — composition","quote":"RJ is an acidic secretion with a pH of 3.5–4.2. It mostly consists of water 60–70 %, sugars 7–18 %, proteins 9–18 %, lipids 3–8%, minerals … Major lipids in it consist of 10-hydroxy-2-decanoic acid and sebacic acid","accessed":"2026-08-27"},{"id":"kumar2024_limits","url":"https://europepmc.org/article/PMC/PMC11408027","label":"Kumar et al., Heliyon 2024 — limitations of the evidence base","quote":"Variability in the composition of RJ due to differences in bee species, diet, and environmental factors poses challenges in standardizing dosages and formulations. Lastly, the limited number of large-scale, well-controlled clinical trials restricts the ability to draw definitive conclusions","accessed":"2026-08-27"},{"id":"hsa_prohibited_2025","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev 001 (Oct 2025)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [royal jelly / 10-HDA not listed in Annex A or B]","accessed":"2026-08-27"},{"id":"hsa_hs_limits","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), clause 4.8 and Tables 4–5 (vitamins and minerals limits)","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/royal-jelly","label":"iHerb Singapore — Royal Jelly category (default order)","quote":"California Gold Nutrition, Royal Jelly, 500 mg … NOW Foods, Royal Jelly, 60 Capsules (500 mg per Capsule) … Imperial Elixir, Ginseng and Royal Jelly … Honey Gardens, Royal Jelly, In Raw Honey … Swanson Vitamins, Royal Jelly, 100 Softgels","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:29.426925+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}