Rivaroxaban
Medication
direct oral anticoagulant
heart & blood pressure
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Prescribed to prevent and treat blood clots and strokes
When to take
HealthHub: 15 mg and 20 mg tablets are taken after food
Take with
Water · NHS: with food; 2.5/10 mg with or without
Pros & cons
Pros
- HealthHub: no drastic lifestyle changes needed
- HealthHub: tablets can be crushed and mixed with water
- NHS: you can eat and drink as normal on it
Cons
- NHS: bleeding and bruising more easily than usual
- FDA: boxed warning on spinal or epidural haematoma
- FDA: stopping early raises the risk of clots
Sources
- HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally) · read 2026-08-27
what it says
“All 34 registered rivaroxaban rows read Forensicclassification 'Prescription Only' — brands Xarelto, Invarox, Estaelto, Rivason, Rivaroxaban-Teva, Jbrivo, Oranxa, Zyroxaban, Xabarem, Rivoban; strengths 2.5, 10, 15, 20 mg and 1 mg/ml granules; ATC B01AF01.”
- NHS Medicines A-Z — Rivaroxaban: what rivaroxaban is for · read 2026-08-27
what it says
“Rivaroxaban is a medicine used to help prevent blood clots. It is only available with a prescription … It's used to prevent conditions such as … deep vein thrombosis (DVT) … pulmonary embolism … atrial fibrillation”
- NHS Medicines A-Z — Rivaroxaban: how to take rivaroxaban · read 2026-08-27
what it says
“Rivaroxaban comes as a tablet that you swallow with water … You'll usually need to take it once or twice a day, at the same time every day. You take it with food.”
- NHS Medicines A-Z — Rivaroxaban: side effects · read 2026-08-27
what it says
“One of the most common side effects of taking rivaroxaban is bleeding more than usual … nosebleeds; bleeding from your gums when you brush your teeth; bruises that come up more easily”
- NHS Medicines A-Z — Rivaroxaban: who can and cannot take it · read 2026-08-27
what it says
“you have a condition that increases your risk of serious bleeding, such as a stomach ulcer or bowel ulcer … you've recently had a bleed in your brain … you have liver disease … antiphospholipid syndrome … pregnant or breastfeeding”
- NHS Medicines A-Z — Rivaroxaban: taking it with other medicines, food and drink · read 2026-08-27
what it says
“other medicines that prevent blood clots (anticoagulants), such as warfarin … some types of antidepressant medicines, such as SSRIs; some painkillers or anti-inflammatories (NSAIDs) … You can eat and drink as normal while taking rivaroxaban.”
- HealthHub (Pharmaceutical Society of Singapore) — Rivaroxaban: what is this medication for · read 2026-08-27
what it says
“Rivaroxaban is a blood thinning medication that prevents blood clots from forming in your body. It does not remove clots that are already formed, but prevents these clots from becoming bigger.”
- HealthHub — Rivaroxaban: how should I take this medication · read 2026-08-27
what it says
“If you are taking 2.5mg or 10mg tablets, take this medication with or without food. If you are taking 15mg or 20mg tablets, take this medication after food … you may crush the tablets and mix with water”
- HealthHub — Rivaroxaban: what should I do if I forget a dose (15 mg twice daily regimen) · read 2026-08-27
what it says
“take a dose immediately to ensure a total of 30mg is taken per day (in this case, two 15mg tablets may be taken together) … Do not take more than two 15mg tablets in a day.”
- HealthHub — Rivaroxaban: what precautions should I take · read 2026-08-27
what it says
“There is no need to make drastic changes to your lifestyle. However, avoid sports or activities that may cause you to get injured … Inform all doctors, dentists and pharmacists that you are on Rivaroxaban.”
- HealthHub — Rivaroxaban: what food or medication should I avoid · read 2026-08-27
what it says
“Examples of medications or supplements that may affect Rivaroxaban: Antibiotics for tuberculosis (e.g. Rifampicin); Medications to treat fungal infections (e.g. Itraconazole); Seizure medications (e.g. Carbamazepine, Phenytoin); St John's Wort”
- US FDA label — XARELTO (rivaroxaban), section 2 Dosage and Administration, via openFDA drug/label.json · read 2026-08-27
what it says
“Nonvalvular Atrial Fibrillation: 15 or 20 mg, once daily with food … CAD or PAD: 2.5 mg orally twice daily with or without food, in combination with aspirin (75–100 mg) once daily”
- US FDA label — XARELTO (rivaroxaban), section 2.1 treatment of DVT and/or PE, via openFDA drug/label.json · read 2026-08-27
what it says
“Treatment of DVT and/or PE: 15 mg orally twice daily with food for the first 21 days followed by 20 mg orally once daily with food for the remaining treatment”
- US FDA label — XARELTO (rivaroxaban), boxed warning, via openFDA drug/label.json · read 2026-08-27
what it says
“(A) PREMATURE DISCONTINUATION OF XARELTO INCREASES THE RISK OF THROMBOTIC EVENTS, (B) SPINAL/EPIDURAL HEMATOMA … Epidural or spinal hematomas have occurred … These hematomas may result in long-term or permanent paralysis.”
- US FDA label — XARELTO (rivaroxaban), section 4 Contraindications, via openFDA drug/label.json · read 2026-08-27
what it says
“XARELTO is contraindicated in patients with: active pathological bleeding … severe hypersensitivity reaction to XARELTO (e.g., anaphylactic reactions)”
- US FDA label — XARELTO (rivaroxaban), section 7 Drug Interactions, via openFDA drug/label.json · read 2026-08-27
what it says
“Avoid combined P-gp and strong CYP3A inhibitors and inducers … Anticoagulants: Avoid concomitant use … Coadministration of enoxaparin, warfarin, aspirin, clopidogrel and chronic NSAID use may increase the risk of bleeding.”
Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.