{"ok":true,"entry":{"slug":"rivaroxaban","kind":"medication","name":"rivaroxaban","aliases":["Xarelto"],"brands_sg":["Xarelto","Invarox","Estaelto","Rivason","Rivaroxaban-Teva"],"class":"direct oral anticoagulant","tags":["heart-bp"],"use_for":"prescribed to prevent and treat blood clots and strokes","use_after":"healthhub: 15 mg and 20 mg tablets are taken after food","use_duration":null,"take_with":"water · nhs: with food; 2.5/10 mg with or without","pros":["healthhub: no drastic lifestyle changes needed","healthhub: tablets can be crushed and mixed with water","nhs: you can eat and drink as normal on it"],"cons":["nhs: bleeding and bruising more easily than usual","fda: boxed warning on spinal or epidural haematoma","fda: stopping early raises the risk of clots"],"dose_note":"the us fda label for xarelto gives 20 mg once daily with the evening meal for nonvalvular atrial fibrillation (15 mg once daily if crcl is 50 ml/min or less), and '15 mg orally twice daily with food for the first 21 days' when treating dvt or pe — 15 mg twice daily, 30 mg in a day, is the highest daily figure the label carries; the lowest is 2.5 mg twice daily for coronary or peripheral artery disease. healthhub reports the same ceiling on the twice-daily regimen — a total of 30 mg per day, and no more than two 15 mg tablets in a day. sg-registered strengths are 2.5, 10, 15 and 20 mg tablets plus a 1 mg/ml oral suspension. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["a bleeding condition, ulcer or recent brain bleed (nhs)","liver disease or antiphospholipid syndrome (nhs)","pregnancy or breastfeeding — nhs: not used","fda: contraindicated in active pathological bleeding"],"clashes":[{"src":["nhs_riva_mix","fda_riva_di"],"note":"nhs lists other clot-preventing medicines among poor mixes; fda: avoid concurrent use","with":"other anticoagulants such as warfarin"},{"src":["nhs_riva_mix","fda_riva_di"],"note":"nhs lists painkillers or anti-inflammatories among poor mixes; fda: may increase bleeding risk","with":"nsaids and anti-inflammatory painkillers"},{"src":["nhs_riva_mix"],"note":"nhs lists antidepressant medicines such as ssris among poor mixes","with":"ssri antidepressants"},{"src":["fda_riva_di","hh_riva_food"],"note":"fda: avoid combined p-gp and strong cyp3a inhibitors — they raise rivaroxaban levels and bleeding risk","with":"ketoconazole, itraconazole, ritonavir"},{"src":["fda_riva_di","hh_riva_food"],"note":"fda and healthhub: strong inducers lower rivaroxaban levels; fda: avoid concomitant use","with":"rifampicin, carbamazepine, phenytoin, st john's wort"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 34 registered rivaroxaban rows read Forensicclassification 'Prescription Only' — brands Xarelto, Invarox, Estaelto, Rivason, Rivaroxaban-Teva, Jbrivo, Oranxa, Zyroxaban, Xabarem, Rivoban; strengths 2.5, 10, 15, 20 mg and 1 mg/ml granules; ATC B01AF01.","accessed":"2026-08-27"},{"id":"nhs_riva_about","url":"https://www.nhs.uk/medicines/rivaroxaban/","label":"NHS Medicines A-Z — Rivaroxaban: what rivaroxaban is for","quote":"Rivaroxaban is a medicine used to help prevent blood clots. It is only available with a prescription … It's used to prevent conditions such as … deep vein thrombosis (DVT) … pulmonary embolism … atrial fibrillation","accessed":"2026-08-27"},{"id":"nhs_riva_howto","url":"https://www.nhs.uk/medicines/rivaroxaban/","label":"NHS Medicines A-Z — Rivaroxaban: how to take rivaroxaban","quote":"Rivaroxaban comes as a tablet that you swallow with water … You'll usually need to take it once or twice a day, at the same time every day. You take it with food.","accessed":"2026-08-27"},{"id":"nhs_riva_side","url":"https://www.nhs.uk/medicines/rivaroxaban/","label":"NHS Medicines A-Z — Rivaroxaban: side effects","quote":"One of the most common side effects of taking rivaroxaban is bleeding more than usual … nosebleeds; bleeding from your gums when you brush your teeth; bruises that come up more easily","accessed":"2026-08-27"},{"id":"nhs_riva_who","url":"https://www.nhs.uk/medicines/rivaroxaban/","label":"NHS Medicines A-Z — Rivaroxaban: who can and cannot take it","quote":"you have a condition that increases your risk of serious bleeding, such as a stomach ulcer or bowel ulcer … you've recently had a bleed in your brain … you have liver disease … antiphospholipid syndrome … pregnant or breastfeeding","accessed":"2026-08-27"},{"id":"nhs_riva_mix","url":"https://www.nhs.uk/medicines/rivaroxaban/","label":"NHS Medicines A-Z — Rivaroxaban: taking it with other medicines, food and drink","quote":"other medicines that prevent blood clots (anticoagulants), such as warfarin … some types of antidepressant medicines, such as SSRIs; some painkillers or anti-inflammatories (NSAIDs) … You can eat and drink as normal while taking rivaroxaban.","accessed":"2026-08-27"},{"id":"hh_riva_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/rivaroxaban","label":"HealthHub (Pharmaceutical Society of Singapore) — Rivaroxaban: what is this medication for","quote":"Rivaroxaban is a blood thinning medication that prevents blood clots from forming in your body. It does not remove clots that are already formed, but prevents these clots from becoming bigger.","accessed":"2026-08-27"},{"id":"hh_riva_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/rivaroxaban","label":"HealthHub — Rivaroxaban: how should I take this medication","quote":"If you are taking 2.5mg or 10mg tablets, take this medication with or without food. If you are taking 15mg or 20mg tablets, take this medication after food … you may crush the tablets and mix with water","accessed":"2026-08-27"},{"id":"hh_riva_missed","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/rivaroxaban","label":"HealthHub — Rivaroxaban: what should I do if I forget a dose (15 mg twice daily regimen)","quote":"take a dose immediately to ensure a total of 30mg is taken per day (in this case, two 15mg tablets may be taken together) … Do not take more than two 15mg tablets in a day.","accessed":"2026-08-27"},{"id":"hh_riva_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/rivaroxaban","label":"HealthHub — Rivaroxaban: what precautions should I take","quote":"There is no need to make drastic changes to your lifestyle. However, avoid sports or activities that may cause you to get injured … Inform all doctors, dentists and pharmacists that you are on Rivaroxaban.","accessed":"2026-08-27"},{"id":"hh_riva_food","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/rivaroxaban","label":"HealthHub — Rivaroxaban: what food or medication should I avoid","quote":"Examples of medications or supplements that may affect Rivaroxaban: Antibiotics for tuberculosis (e.g. Rifampicin); Medications to treat fungal infections (e.g. Itraconazole); Seizure medications (e.g. Carbamazepine, Phenytoin); St John's Wort","accessed":"2026-08-27"},{"id":"fda_riva_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22rivaroxaban%22&limit=1","label":"US FDA label — XARELTO (rivaroxaban), section 2 Dosage and Administration, via openFDA drug/label.json","quote":"Nonvalvular Atrial Fibrillation: 15 or 20 mg, once daily with food … CAD or PAD: 2.5 mg orally twice daily with or without food, in combination with aspirin (75–100 mg) once daily","accessed":"2026-08-27"},{"id":"fda_riva_dose_dvt","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22rivaroxaban%22&limit=1","label":"US FDA label — XARELTO (rivaroxaban), section 2.1 treatment of DVT and/or PE, via openFDA drug/label.json","quote":"Treatment of DVT and/or PE: 15 mg orally twice daily with food for the first 21 days followed by 20 mg orally once daily with food for the remaining treatment","accessed":"2026-08-27"},{"id":"fda_riva_boxed","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22rivaroxaban%22&limit=1","label":"US FDA label — XARELTO (rivaroxaban), boxed warning, via openFDA drug/label.json","quote":"(A) PREMATURE DISCONTINUATION OF XARELTO INCREASES THE RISK OF THROMBOTIC EVENTS, (B) SPINAL/EPIDURAL HEMATOMA … Epidural or spinal hematomas have occurred … These hematomas may result in long-term or permanent paralysis.","accessed":"2026-08-27"},{"id":"fda_riva_ci","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22rivaroxaban%22&limit=1","label":"US FDA label — XARELTO (rivaroxaban), section 4 Contraindications, via openFDA drug/label.json","quote":"XARELTO is contraindicated in patients with: active pathological bleeding … severe hypersensitivity reaction to XARELTO (e.g., anaphylactic reactions)","accessed":"2026-08-27"},{"id":"fda_riva_di","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22rivaroxaban%22&limit=1","label":"US FDA label — XARELTO (rivaroxaban), section 7 Drug Interactions, via openFDA drug/label.json","quote":"Avoid combined P-gp and strong CYP3A inhibitors and inducers … Anticoagulants: Avoid concomitant use … Coadministration of enoxaparin, warfarin, aspirin, clopidogrel and chronic NSAID use may increase the risk of bleeding.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:29.426925+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}