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Reishi

Supplement mushroom immunesleep
Aka: Ganoderma lucidum, lingzhi
Brands seen in Singapore: California Gold Nutrition, Swanson Vitamins, Real Mushrooms, Nutricost, Nature's Way
Third-party tested: Real Mushrooms certifies other products with NSF Certified for Sport, but nothing for reishi.Certification is granted per product, so check the tub you actually own. Not being listed is not the same as failing.
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Immune markers in trials; overall evidence quality very low
When to take
Daily
Take with
One trial gave a 225 mg capsule after lunch or dinner
Studied for
Trials ran 1 to 24 weeks at 200–11,200 mg
Pros & cons
Pros
  • 17 RCTS, 971 people pooled in a 2025 review
  • Immune cell counts rose in an 84-day RCT in adults
  • That RCT reported it safe and well tolerated
Cons
  • Grade quality: very low across all outcomes
  • No change in inflammatory markers, lipids or glucose
  • Insomnia was among side effects reported by users
Sources
  1. The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials (Food Sci Nutr 2025) — scope and dose range · read 2026-08-27
    what it says
    “the impact of Ganoderma lucidum supplementation (200-11,200 mg/day, 1-24 weeks) on health-related indices … Pooled analysis of 17 randomized controlled trials (RCTs) involving 971 participants”
  2. Ganoderma lucidum GRADE-assessed systematic review, Food Sci Nutr 2025 — certainty of evidence · read 2026-08-27
    what it says
    “the quality of evidence was very low across all outcomes. Ganoderma lucidum supplementation may have modest effects on certain health indices, but the evidence is limited by very low quality.”
  3. Ganoderma lucidum GRADE-assessed systematic review, Food Sci Nutr 2025 — null outcomes · read 2026-08-27
    what it says
    “No significant effects were observed on body fat, waist circumference, blood pressure, fasting glucose, lipid profile, inflammatory markers, or liver enzymes.”
  4. Evaluation of Immune Modulation by β-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomized Controlled Trial (Foods 2023) — immune outcomes · read 2026-08-27
    what it says
    “Participants … self-administer the interventions or placebos on a daily basis for 84 days … exhibited a significant enhancement in various immune cell populations, including CD3+, CD4+, CD8+ T-lymphocytes … natural killer cell counts”
  5. Reishi β-glucan RCT, Foods 2023 — tolerability · read 2026-08-27
    what it says
    “the intervention was found to be safe and well tolerated, with no statistically significant changes observed in markers of kidney or liver function in either group”
  6. Symptom improvements and adverse effects with Reishi mushroom use: A Cross-Sectional survey of cancer patients (Integr Med Res 2024) — adverse events · read 2026-08-27
    what it says
    “Among 1374 participants … 125 (9.1 %) also reported a range of AEs, including dry mouth (5 %), constipation (4 %), insomnia (3 %), pruritus (3 %) and vertigo (3 %).”
  7. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice (Sci Rep 2021) · read 2026-08-27
    what it says
    “Ganoderma lucidum is a medicinal mushroom used in traditional Chinese medicine with putative tranquilizing effects … GLAA promotes sleep through a gut microbiota-dependent and serotonin-associated pathway in mice.”
  8. Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study in healthy volunteers (Pharm Biol 2017) — dosing schedule · read 2026-08-27
    what it says
    “Forty-two healthy subjects … requested to intake GL (n = 21) or placebo (n = 21) capsule (225 mg; after lunch or dinner) for six consecutive months”
  9. Herb-drug interactions between the medicinal mushrooms Lingzhi and Yunzhi and cytotoxic anticancer drugs: a systematic review (Chin Med 2020) · read 2026-08-27
    what it says
    “the most commonly used cytotoxic drugs with Lingzhi were cisplatin, 5-fluorouracil (5-FU) and paclitaxel … Only two clinical pharmacokinetic studies were available showing no significant interactions between Polysaccharide K (PSK) and Tegafur”
  10. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev 001 (Oct 2025), Annex A/B — searched, no row for this ingredient · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  11. iHerb Singapore — Mushrooms > Reishi category (default order, 55 results); first 5 distinct brands: California Gold Nutrition, Swanson Vitamins, Real Mushrooms, Nutricost, Nature's Way · read 2026-08-27
    what it says
    “California Gold Nutrition, Reishi (Ganoderma lucidum), Full Spectrum … Swanson Vitamins, Reishi Mushroom, 600 mg … Real Mushrooms, Reishi, Mushroom Extract Powder … Nutricost, Reishi Mushroom … Nature's Way, Echinacea Astragalus & Reishi”
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Updated 2026-08-30. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.