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Red clover

Supplement botanical women's health
Aka: Trifolium pratense
Brands seen in Singapore: Nature's Way, Nature's Answer, Swanson, NOW Foods, Vitacost
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Hot flushes in menopause — small effect, evidence mixed
When to take
Daily
Studied for
Pooled trials ran 12 weeks to 12 months
Pros & cons
Pros
  • 2026 meta-analysis of 9 RCTS: fewer hot flushes
  • Smd −0.446 vs placebo; most trials low risk of bias
  • Extracts studied for as long as 2 years, well tolerated
Cons
  • NCCIH: no conclusive evidence for any condition
  • Earlier hot-flash trials were inconsistent and biased
  • Bone-density results in postmenopausal women conflict
Sources
  1. NCCIH — Red Clover (What is red clover used for) · read 2026-08-27
    what it says
    “Dietary supplements containing red clover are promoted for women's health conditions.”
  2. NCCIH — Red Clover (What does the research say) · read 2026-08-27
    what it says
    “Red clover has been studied in people, but the research hasn't shown conclusive evidence of benefits for any health condition.”
  3. NCCIH — Red Clover (hot flashes) · read 2026-08-27
    what it says
    “Studies on the effects of red clover on hot flashes associated with menopause have had inconsistent results, and some of the studies had a high risk of bias.”
  4. NCCIH — Red Clover (bone density) · read 2026-08-27
    what it says
    “Only a small number of studies have been done on the effects of red clover on bone density in postmenopausal women, and the results have been inconsistent.”
  5. NCCIH — Red Clover (safety) · read 2026-08-27
    what it says
    “Red clover extracts have been used in clinical studies for as long as 2 years with apparent safety, and they appear to be well tolerated.”
  6. NCCIH — Red Clover (pregnancy and breastfeeding) · read 2026-08-27
    what it says
    “Red clover supplements may be unsafe for use during pregnancy or while breastfeeding.”
  7. NCCIH — Red Clover (interactions with medicines) · read 2026-08-27
    what it says
    “If you take any type of medicine, talk with your health care provider before using any herbal product; some herbs and medicines interact in harmful ways.”
  8. The effectiveness of red clover on hot-flash in menopausal women: a GRADE-assessed systematic review and meta-analysis (Eur J Obstet Gynecol Reprod Biol 2026) — results · read 2026-08-27
    what it says
    “Meta-analysis revealed a statistically significant reduction in frequency of hot flash favoring red clover over placebo (SMD = -0.446; 95% CI: -0.807 to -0.084; p = 0.016), representing a small-to-moderate effect.”
  9. EJOGRB 2026 red clover meta-analysis — trials and doses pooled · read 2026-08-27
    what it says
    “Nine randomized controlled trials (RCTs) met inclusion criteria, enrolling women aged 40-65 years with baseline hot flush frequencies of 2.1-11.7 per day. Red clover doses ranged from 37.1-160 mg daily isoflavones, with treatment durations of 12 weeks to 12 months.”
  10. EJOGRB 2026 red clover meta-analysis — risk of bias and sensitivity · read 2026-08-27
    what it says
    “Sensitivity analyses confirmed result stability, and no publication bias was detected. Most trials exhibited low risk of bias.”
  11. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025) · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list”
  12. iHerb Singapore — Red Clover category (default order); first 5 distinct brands in page order: Nature's Way, Nature's Answer, Swanson, NOW Foods, Vitacost · read 2026-08-27
    what it says
    “Nature's Way, Red Clover … Nature's Answer, Red Clover Aerial Parts, Fluid Extract … Swanson Vitamins, Full Spectrum® Red Clover Blossom, 430 mg … NOW Foods, Red Clover, 375 mg … Vitacost, Red Clover Blossom”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.