{"ok":true,"entry":{"slug":"red-clover","kind":"supplement","name":"red clover","aliases":["Trifolium pratense"],"brands_sg":["Nature's Way","Nature's Answer","Swanson","NOW Foods","Vitacost"],"class":"botanical","tags":["womens-health"],"use_for":"hot flushes in menopause — small effect, evidence mixed","use_after":"daily","use_duration":"pooled trials ran 12 weeks to 12 months","take_with":null,"pros":["2026 meta-analysis of 9 rcts: fewer hot flushes","smd −0.446 vs placebo; most trials low risk of bias","extracts studied for as long as 2 years, well tolerated"],"cons":["nccih: no conclusive evidence for any condition","earlier hot-flash trials were inconsistent and biased","bone-density results in postmenopausal women conflict"],"dose_note":"the nine rcts pooled in the 2026 ejog meta-analysis used 37.1–160 mg a day of red clover isoflavones for 12 weeks to 12 months, in women aged 40–65 with 2.1–11.7 hot flushes a day; nccih does not recommend an amount, and no authority has set one","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["pregnancy or breastfeeding — nccih says it may be unsafe","on any medicine — nccih says to check with a provider first","not listed in hsa annex a or b (oct 2025) — not a clearance"],"clashes":[{"src":["nccih_rc_interactions"],"note":"nccih names no specific interaction; it says some herbs and medicines interact in harmful ways and advises checking first","with":"medicines generally"}],"sources":[{"id":"nccih_rc_uses","url":"https://www.nccih.nih.gov/health/red-clover","label":"NCCIH — Red Clover (What is red clover used for)","quote":"Dietary supplements containing red clover are promoted for women's health conditions.","accessed":"2026-08-27"},{"id":"nccih_rc_evidence","url":"https://www.nccih.nih.gov/health/red-clover","label":"NCCIH — Red Clover (What does the research say)","quote":"Red clover has been studied in people, but the research hasn't shown conclusive evidence of benefits for any health condition.","accessed":"2026-08-27"},{"id":"nccih_rc_hotflash","url":"https://www.nccih.nih.gov/health/red-clover","label":"NCCIH — Red Clover (hot flashes)","quote":"Studies on the effects of red clover on hot flashes associated with menopause have had inconsistent results, and some of the studies had a high risk of bias.","accessed":"2026-08-27"},{"id":"nccih_rc_bone","url":"https://www.nccih.nih.gov/health/red-clover","label":"NCCIH — Red Clover (bone density)","quote":"Only a small number of studies have been done on the effects of red clover on bone density in postmenopausal women, and the results have been inconsistent.","accessed":"2026-08-27"},{"id":"nccih_rc_safety","url":"https://www.nccih.nih.gov/health/red-clover","label":"NCCIH — Red Clover (safety)","quote":"Red clover extracts have been used in clinical studies for as long as 2 years with apparent safety, and they appear to be well tolerated.","accessed":"2026-08-27"},{"id":"nccih_rc_pregnancy","url":"https://www.nccih.nih.gov/health/red-clover","label":"NCCIH — Red Clover (pregnancy and breastfeeding)","quote":"Red clover supplements may be unsafe for use during pregnancy or while breastfeeding.","accessed":"2026-08-27"},{"id":"nccih_rc_interactions","url":"https://www.nccih.nih.gov/health/red-clover","label":"NCCIH — Red Clover (interactions with medicines)","quote":"If you take any type of medicine, talk with your health care provider before using any herbal product; some herbs and medicines interact in harmful ways.","accessed":"2026-08-27"},{"id":"ejog2026_rc_result","url":"https://europepmc.org/article/MED/42269521","label":"The effectiveness of red clover on hot-flash in menopausal women: a GRADE-assessed systematic review and meta-analysis (Eur J Obstet Gynecol Reprod Biol 2026) — results","quote":"Meta-analysis revealed a statistically significant reduction in frequency of hot flash favoring red clover over placebo (SMD = -0.446; 95% CI: -0.807 to -0.084; p = 0.016), representing a small-to-moderate effect.","accessed":"2026-08-27"},{"id":"ejog2026_rc_dose","url":"https://europepmc.org/article/MED/42269521","label":"EJOGRB 2026 red clover meta-analysis — trials and doses pooled","quote":"Nine randomized controlled trials (RCTs) met inclusion criteria, enrolling women aged 40-65 years with baseline hot flush frequencies of 2.1-11.7 per day. Red clover doses ranged from 37.1-160 mg daily isoflavones, with treatment durations of 12 weeks to 12 months.","accessed":"2026-08-27"},{"id":"ejog2026_rc_bias","url":"https://europepmc.org/article/MED/42269521","label":"EJOGRB 2026 red clover meta-analysis — risk of bias and sensitivity","quote":"Sensitivity analyses confirmed result stability, and no publication bias was detected. Most trials exhibited low risk of bias.","accessed":"2026-08-27"},{"id":"hsa_prohibited_2025","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/red-clover","label":"iHerb Singapore — Red Clover category (default order); first 5 distinct brands in page order: Nature's Way, Nature's Answer, Swanson, NOW Foods, Vitacost","quote":"Nature's Way, Red Clover … Nature's Answer, Red Clover Aerial Parts, Fluid Extract … Swanson Vitamins, Full Spectrum® Red Clover Blossom, 430 mg … NOW Foods, Red Clover, 375 mg … Vitacost, Red Clover Blossom","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:29.426925+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}