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Raspberry ketones

Supplement specialty compound general nutrition
Aka: 4-(4-hydroxyphenyl)butan-2-one
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Sold as a fat burner · no trial has tested it alone
Pros & cons
Pros
  • No serious adverse effects in the one 8-week trial
Cons
  • ODS: insufficient research to draw firm conclusions
  • The one trial used a multi-ingredient blend
  • Safety of 100–1,400 mg doses is unevaluated in humans
Sources
  1. NIH ODS — Dietary Supplements for Weight Loss (Health Professional), updated 18 May 2022; read via the archive.org capture of 26 Aug 2026 because ods.od.nih.gov returns HTTP 403 to direct fetches — Table 1 summary row for raspberry ketone · read 2026-08-27
    what it says
    “Raspberry ketone … Studied only in combination with other ingredients … Research findings: Insufficient research to draw firm conclusions … No safety concerns reported in one 8-week study, but not well studied”
  2. NIH ODS — Dietary Supplements for Weight Loss (Health Professional), updated 18 May 2022; read via the archive.org capture of 26 Aug 2026 because ods.od.nih.gov returns HTTP 403 to direct fetches — the single randomised trial · read 2026-08-27
    what it says
    “Only one randomized controlled trial has examined the effects of a dietary supplement containing raspberry ketone … This product contained 2,000 mg of a proprietary blend of raspberry ketone, caffeine, bitter orange, ginger, garlic, cayenne, L-theanine, and pepper extract”
  3. NIH ODS — Dietary Supplements for Weight Loss (Health Professional), updated 18 May 2022; read via the archive.org capture of 26 Aug 2026 because ods.od.nih.gov returns HTTP 403 to direct fetches — how that trial reported its results · read 2026-08-27
    what it says
    “25 of the 70 participants dropped out of the study, and results were reported for only the 45 participants who completed the study”
  4. NIH ODS — Dietary Supplements for Weight Loss (Health Professional), updated 18 May 2022; read via the archive.org capture of 26 Aug 2026 because ods.od.nih.gov returns HTTP 403 to direct fetches — why that trial cannot isolate raspberry ketone · read 2026-08-27
    what it says
    “the product contained many ingredients in addition to raspberry ketone, making it impossible to determine the effects of raspberry ketone alone”
  5. NIH ODS — Dietary Supplements for Weight Loss (Health Professional), updated 18 May 2022; read via the archive.org capture of 26 Aug 2026 because ods.od.nih.gov returns HTTP 403 to direct fetches — typical doses and hype · read 2026-08-27
    what it says
    “Typical diets provide only a few mg of raspberry ketone a day. Doses contained in dietary supplements typically range from 100 to 1,400 mg, and the safety of such doses has never been evaluated in humans”
  6. HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (October 2025) — Annex A (118 rows) and Annex B (4 rows): raspberry ketone / Rubus idaeus is NOT LISTED in either; Annex A runs 89. Red yeast rice then 90. Sanguinaria, with no Rubus between them · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  7. HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 (January 2026), clause 4.8 with Tables 4–5, which list vitamins and minerals only — no botanical or fibre rows · read 2026-08-27
    what it says
    “4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.