{"ok":true,"entry":{"slug":"raspberry-ketones","kind":"supplement","name":"raspberry ketones","aliases":["4-(4-hydroxyphenyl)butan-2-one"],"brands_sg":[],"class":"specialty compound","tags":["general"],"use_for":"sold as a fat burner · no trial has tested it alone","use_after":null,"use_duration":null,"take_with":null,"pros":["no serious adverse effects in the one 8-week trial"],"cons":["ods: insufficient research to draw firm conclusions","the one trial used a multi-ingredient blend","safety of 100–1,400 mg doses is unevaluated in humans"],"dose_note":"supplement doses typically run 100 to 1,400 mg a day and ods states the safety of such doses has never been evaluated in humans, against a normal dietary intake of only a few mg a day; the single randomised trial gave 70 overweight adults 2,000 mg of a proprietary blend containing raspberry ketone plus caffeine, bitter orange, ginger, garlic, cayenne, l-theanine, pepper extract, b-vitamins and chromium for 8 weeks alongside a calorie-restricted diet and exercise, so no dose of raspberry ketone on its own has been tested; no rda, ul, fda daily value or hsa singapore daily limit exists","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["no human trial has tested raspberry ketone on its own","the safety of 100–1,400 mg supplement doses is unevaluated","the one trial reported only 45 of its 70 participants","not listed in hsa annex a or b — that is not a safety finding"],"clashes":[],"sources":[{"id":"ods_wl_rk_table","url":"https://web.archive.org/web/20260826105104/https://ods.od.nih.gov/factsheets/WeightLoss-HealthProfessional/","label":"NIH ODS — Dietary Supplements for Weight Loss (Health Professional), updated 18 May 2022; read via the archive.org capture of 26 Aug 2026 because ods.od.nih.gov returns HTTP 403 to direct fetches — Table 1 summary row for raspberry ketone","quote":"Raspberry ketone … Studied only in combination with other ingredients … Research findings: Insufficient research to draw firm conclusions … No safety concerns reported in one 8-week study, but not well studied","accessed":"2026-08-27"},{"id":"ods_wl_rk_trial","url":"https://web.archive.org/web/20260826105104/https://ods.od.nih.gov/factsheets/WeightLoss-HealthProfessional/","label":"NIH ODS — Dietary Supplements for Weight Loss (Health Professional), updated 18 May 2022; read via the archive.org capture of 26 Aug 2026 because ods.od.nih.gov returns HTTP 403 to direct fetches — the single randomised trial","quote":"Only one randomized controlled trial has examined the effects of a dietary supplement containing raspberry ketone … This product contained 2,000 mg of a proprietary blend of raspberry ketone, caffeine, bitter orange, ginger, garlic, cayenne, L-theanine, and pepper extract","accessed":"2026-08-27"},{"id":"ods_wl_rk_dropouts","url":"https://web.archive.org/web/20260826105104/https://ods.od.nih.gov/factsheets/WeightLoss-HealthProfessional/","label":"NIH ODS — Dietary Supplements for Weight Loss (Health Professional), updated 18 May 2022; read via the archive.org capture of 26 Aug 2026 because ods.od.nih.gov returns HTTP 403 to direct fetches — how that trial reported its results","quote":"25 of the 70 participants dropped out of the study, and results were reported for only the 45 participants who completed the study","accessed":"2026-08-27"},{"id":"ods_wl_rk_confound","url":"https://web.archive.org/web/20260826105104/https://ods.od.nih.gov/factsheets/WeightLoss-HealthProfessional/","label":"NIH ODS — Dietary Supplements for Weight Loss (Health Professional), updated 18 May 2022; read via the archive.org capture of 26 Aug 2026 because ods.od.nih.gov returns HTTP 403 to direct fetches — why that trial cannot isolate raspberry ketone","quote":"the product contained many ingredients in addition to raspberry ketone, making it impossible to determine the effects of raspberry ketone alone","accessed":"2026-08-27"},{"id":"ods_wl_rk_dose","url":"https://web.archive.org/web/20260826105104/https://ods.od.nih.gov/factsheets/WeightLoss-HealthProfessional/","label":"NIH ODS — Dietary Supplements for Weight Loss (Health Professional), updated 18 May 2022; read via the archive.org capture of 26 Aug 2026 because ods.od.nih.gov returns HTTP 403 to direct fetches — typical doses and hype","quote":"Typical diets provide only a few mg of raspberry ketone a day. Doses contained in dietary supplements typically range from 100 to 1,400 mg, and the safety of such doses has never been evaluated in humans","accessed":"2026-08-27"},{"id":"hsa_prohibited","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (October 2025) — Annex A (118 rows) and Annex B (4 rows): raspberry ketone / Rubus idaeus is NOT LISTED in either; Annex A runs 89. Red yeast rice then 90. Sanguinaria, with no Rubus between them","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs_guidelines","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 (January 2026), clause 4.8 with Tables 4–5, which list vitamins and minerals only — no botanical or fibre rows","quote":"4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:29.426925+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}