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Pyridoxal-5-phosphate

Supplement vitamin B6 form women's healthgeneral nutrition
Aka: P-5-P, P5P, active B6
Brands seen in Singapore: California Gold Nutrition, Solgar, NOW Foods, Natural Factors, Vitamatic
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
The active coenzyme form of vitamin B6
Pros & cons
Pros
  • Plp is an active coenzyme form of vitamin B6
  • B6 works in more than 100 enzyme reactions
  • One trial: 80 mg/day pyridoxine eased pms symptoms
Cons
  • Absorption barely differs between B6 supplement forms
  • 1–6 g/day pyridoxine caused severe sensory neuropathy
  • UL is 100 mg/day and SG caps supplements at the SAMe
Sources
  1. NIH ODS — Vitamin B6 (Health Professional), Introduction · read 2026-08-27
    what it says
    “Pyridoxal 5' phosphate (PLP) and pyridoxamine 5' phosphate (PMP) are the active coenzyme forms of vitamin B6 … involvement in more than 100 enzyme reactions, mostly concerned with protein metabolism”
  2. NIH ODS — Vitamin B6 (Health Professional), Dietary supplements · read 2026-08-27
    what it says
    “Absorption of vitamin B6 from supplements is similar to that from food sources and does not differ substantially among the various forms of supplements”
  3. NIH ODS — Vitamin B6 (Health Professional), Table 1 Recommended Dietary Allowances · read 2026-08-27
    what it says
    “19–50 years | 1.3 mg | 1.3 mg | 1.9 mg | 2.0 mg | 51+ years | 1.7 mg | 1.5 mg”
  4. NIH ODS — Vitamin B6 (Health Professional), Sources of Vitamin B6 (Daily Value) · read 2026-08-27
    what it says
    “The DV for vitamin B6 is 1.7 mg for adults and children age 4 years and older”
  5. NIH ODS — Vitamin B6 (Health Professional), Table 3 Tolerable Upper Intake Levels · read 2026-08-27
    what it says
    “19+ years | 100 mg | 100 mg | 100 mg | 100 mg”
  6. NIH ODS — Vitamin B6 (Health Professional), Health Risks from Excessive Vitamin B6 · read 2026-08-27
    what it says
    “chronic administration of 1–6 g oral pyridoxine per day for 12–40 months can cause severe and progressive sensory neuropathy characterized by ataxia … Symptom severity appears to be dose dependent”
  7. NIH ODS — Vitamin B6 (Health Professional), Premenstrual syndrome · read 2026-08-27
    what it says
    “a double-blind, randomized controlled trial in 94 women found that 80 mg pyridoxine taken daily over the course of three cycles was associated with statistically significant reductions in a broad range of PMS symptoms”
  8. NIH ODS — Vitamin B6 (Health Professional), Nausea and vomiting in pregnancy · read 2026-08-27
    what it says
    “In two randomized, placebo-controlled trials, 30–75 mg of oral pyridoxine per day significantly decreased nausea in pregnant women … could not draw firm conclusions on the value of vitamin B6 to control the symptoms of morning sickness”
  9. NIH ODS — Vitamin B6 (Health Professional), Groups at Risk (impaired renal function) · read 2026-08-27
    what it says
    “People with poor renal function, including those with end-stage renal disease and chronic renal insufficiency, often have low vitamin B6 concentrations. Plasma PLP concentrations are also low in patients receiving maintenance kidney dialysis”
  10. NIH ODS — Vitamin B6 (Health Professional), Interactions with Medications (cycloserine) · read 2026-08-27
    what it says
    “In combination with pyridoxal phosphate, cycloserine increases urinary excretion of pyridoxine. The urinary loss of pyridoxine might exacerbate the seizures and neurotoxicity associated with cycloserine”
  11. NIH ODS — Vitamin B6 (Health Professional), Interactions with Medications (antiepileptic medications) · read 2026-08-27
    what it says
    “Some antiepileptic drugs, including valproic acid, carbamazepine, and phenytoin increase the catabolism rate of vitamin B6 vitamers, resulting in low plasma PLP concentrations and hyperhomocysteinemia”
  12. HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. 020 (January 2026), clause 4.8 and Table 4 Vitamins Limits · read 2026-08-27
    what it says
    “HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5. … Vitamin B6 100mg”
  13. iHerb Singapore — 'Vitamin B6 (Pyridoxine)' category page, default order, 95 results · read 2026-08-27
    what it says
    “Vitamin B6 (Pyridoxine) … 1 - 48 of 95 results … California Gold Nutrition … Solgar … NOW Foods, P-5-P … Natural Factors, BioCoenzymated, B6, Pyridoxal 5'-Phosphate … Vitamatic”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.