{"ok":true,"entry":{"slug":"pyridoxal-5-phosphate","kind":"supplement","name":"pyridoxal-5-phosphate","aliases":["P-5-P","P5P","active B6"],"brands_sg":["California Gold Nutrition","Solgar","NOW Foods","Natural Factors","Vitamatic"],"class":"vitamin B6 form","tags":["womens-health","general"],"use_for":"the active coenzyme form of vitamin b6","use_after":null,"use_duration":null,"take_with":null,"pros":["plp is an active coenzyme form of vitamin b6","b6 works in more than 100 enzyme reactions","one trial: 80 mg/day pyridoxine eased pms symptoms"],"cons":["absorption barely differs between b6 supplement forms","1–6 g/day pyridoxine caused severe sensory neuropathy","ul is 100 mg/day and sg caps supplements at the same"],"dose_note":"the upper limit for adults is 100 mg a day and singapore caps health supplements at 100 mg; pms trials used 80 mg pyridoxine daily, and pregnancy-nausea trials used 30–75 mg a day","dosage":{"ul":100,"unit":"mg","fda_dv":1.7,"rda_ai":"1.3 mg (19–50) · 1.7 mg men, 1.5 mg women (51+)","ul_status":"established","population":"general adult","hsa_max_daily":100},"ul_status":"established","sg_class":null,"cautions":["impaired kidney function or dialysis — plp concentrations are often low","long-term high-dose b6 — sensory neuropathy appears to be dose dependent","pregnancy — trials used 30–75 mg pyridoxine; medical advice first"],"clashes":[{"src":["nih_ods_b6_cycloserine"],"note":"increases urinary pyridoxine excretion in combination with pyridoxal phosphate","with":"cycloserine"},{"src":["nih_ods_b6_aeds"],"note":"raise the catabolism of b6 vitamers, lowering plasma plp","with":"valproic acid, carbamazepine, phenytoin"}],"sources":[{"id":"nih_ods_b6_intro","url":"https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/","label":"NIH ODS — Vitamin B6 (Health Professional), Introduction","quote":"Pyridoxal 5' phosphate (PLP) and pyridoxamine 5' phosphate (PMP) are the active coenzyme forms of vitamin B6 … involvement in more than 100 enzyme reactions, mostly concerned with protein metabolism","accessed":"2026-08-27"},{"id":"nih_ods_b6_supp","url":"https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/","label":"NIH ODS — Vitamin B6 (Health Professional), Dietary supplements","quote":"Absorption of vitamin B6 from supplements is similar to that from food sources and does not differ substantially among the various forms of supplements","accessed":"2026-08-27"},{"id":"nih_ods_b6_rda","url":"https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/","label":"NIH ODS — Vitamin B6 (Health Professional), Table 1 Recommended Dietary Allowances","quote":"19–50 years | 1.3 mg | 1.3 mg | 1.9 mg | 2.0 mg | 51+ years | 1.7 mg | 1.5 mg","accessed":"2026-08-27"},{"id":"nih_ods_b6_dv","url":"https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/","label":"NIH ODS — Vitamin B6 (Health Professional), Sources of Vitamin B6 (Daily Value)","quote":"The DV for vitamin B6 is 1.7 mg for adults and children age 4 years and older","accessed":"2026-08-27"},{"id":"nih_ods_b6_ul_table","url":"https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/","label":"NIH ODS — Vitamin B6 (Health Professional), Table 3 Tolerable Upper Intake Levels","quote":"19+ years | 100 mg | 100 mg | 100 mg | 100 mg","accessed":"2026-08-27"},{"id":"nih_ods_b6_ul","url":"https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/","label":"NIH ODS — Vitamin B6 (Health Professional), Health Risks from Excessive Vitamin B6","quote":"chronic administration of 1–6 g oral pyridoxine per day for 12–40 months can cause severe and progressive sensory neuropathy characterized by ataxia … Symptom severity appears to be dose dependent","accessed":"2026-08-27"},{"id":"nih_ods_b6_pms","url":"https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/","label":"NIH ODS — Vitamin B6 (Health Professional), Premenstrual syndrome","quote":"a double-blind, randomized controlled trial in 94 women found that 80 mg pyridoxine taken daily over the course of three cycles was associated with statistically significant reductions in a broad range of PMS symptoms","accessed":"2026-08-27"},{"id":"nih_ods_b6_pregnancy","url":"https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/","label":"NIH ODS — Vitamin B6 (Health Professional), Nausea and vomiting in pregnancy","quote":"In two randomized, placebo-controlled trials, 30–75 mg of oral pyridoxine per day significantly decreased nausea in pregnant women … could not draw firm conclusions on the value of vitamin B6 to control the symptoms of morning sickness","accessed":"2026-08-27"},{"id":"nih_ods_b6_renal","url":"https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/","label":"NIH ODS — Vitamin B6 (Health Professional), Groups at Risk (impaired renal function)","quote":"People with poor renal function, including those with end-stage renal disease and chronic renal insufficiency, often have low vitamin B6 concentrations. Plasma PLP concentrations are also low in patients receiving maintenance kidney dialysis","accessed":"2026-08-27"},{"id":"nih_ods_b6_cycloserine","url":"https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/","label":"NIH ODS — Vitamin B6 (Health Professional), Interactions with Medications (cycloserine)","quote":"In combination with pyridoxal phosphate, cycloserine increases urinary excretion of pyridoxine. The urinary loss of pyridoxine might exacerbate the seizures and neurotoxicity associated with cycloserine","accessed":"2026-08-27"},{"id":"nih_ods_b6_aeds","url":"https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/","label":"NIH ODS — Vitamin B6 (Health Professional), Interactions with Medications (antiepileptic medications)","quote":"Some antiepileptic drugs, including valproic acid, carbamazepine, and phenytoin increase the catabolism rate of vitamin B6 vitamers, resulting in low plasma PLP concentrations and hyperhomocysteinemia","accessed":"2026-08-27"},{"id":"hsa_hs_limits_b6","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. 020 (January 2026), clause 4.8 and Table 4 Vitamins Limits","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5. … Vitamin B6  100mg","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/vitamin-b6-pyridoxine","label":"iHerb Singapore — 'Vitamin B6 (Pyridoxine)' category page, default order, 95 results","quote":"Vitamin B6 (Pyridoxine) … 1 - 48 of 95 results … California Gold Nutrition … Solgar … NOW Foods, P-5-P … Natural Factors, BioCoenzymated, B6, Pyridoxal 5'-Phosphate … Vitamatic","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:29.426925+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}