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Phosphatidylserine

Supplement phospholipid brain & moodsleep
Aka: PS, Sharp-PS
Brands seen in Singapore: California Gold Nutrition, Doctor's Best, EVLution Nutrition, NOW Foods, Life Extension
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Limited evidence — memory in older adults
When to take
Daily
Studied for
Trials ran 6 weeks to 6 months at 200–600 mg
Pros & cons
Pros
  • 200–600 mg improved memory in older adults
  • Cortisol-lowering is documented in stressed groups
  • In adhd, 3 of 5 studies improved attention
Cons
  • Gains may come from DHA freed in digestion, not ps
  • A 2026 review: not supported as a cognitive enhancer
  • No sleep trials exist — the sleep link is indirect
Sources
  1. Dietary Protocols to Promote and Improve Restful Sleep: A Narrative Review (Nutrition Reviews 2026) — phosphatidylserine section, clinical doses · read 2026-08-27
    what it says
    “Converging evidence from clinical studies demonstrates that supplemental doses of 200-600 mg/d of phosphatidylserine, administered over a period of 6 weeks to 6 months, significantly improve cognitive function and memory performance in elderly individuals”
  2. Nutrition Reviews 2026 — phosphatidylserine section, DHA confound · read 2026-08-27
    what it says
    “it remains unclear whether these cognitive benefits are attributable to the exogenous supply of this nutraceutical per se as opposed to DHA released during digestion”
  3. Nutrition Reviews 2026 — phosphatidylserine section, cortisol · read 2026-08-27
    what it says
    “the cortisol-reducing properties of phosphatidylserine are well documented in chronically stressed populations and may be especially relevant to improve recovery and performance outcomes in athletic and military cohorts”
  4. Nutrition Reviews 2026 — phosphatidylserine section, absence of sleep trials · read 2026-08-27
    what it says
    “while dietary interventions to investigate the potential benefits of phosphatidylserine on sleep measures are currently not available, the findings presented above suggest that … phosphatidylserine may help restore and maintain the neurochemical balance that is conducive to restful sleep”
  5. Nutrition Reviews 2026 — conclusion, how the review ranks these ingredients · read 2026-08-27
    what it says
    “ashwagandha, myoinositol, Rhodiola rosea, and phosphatidylserine may be considered as subsidiary sleep aids by working in synergy with other soporific nutrients or by addressing concomitant physiological mechanisms”
  6. The Impact of Citicoline/Phosphatidylserine Supplementation on Cognitive Performance and Executive Functions in Mental Disorders: A Systematic Review of Controlled Trials (Hum Psychopharmacol 2026) — results · read 2026-08-27
    what it says
    “Regarding ADHD, PS-containing supplementation produced significant improvements in attention and impulsivity in three studies, whereas two studies found no significant differences … findings were heterogeneous and inconsistent across diagnostic groups”
  7. Hum Psychopharmacol 2026 systematic review — conclusion · read 2026-08-27
    what it says
    “Given methodological limitations and high risk of bias, current evidence does not support citicoline or PS-containing compounds as effective cognitive enhancers in mental disorders … these agents should be positioned as adjunctive or investigational”
  8. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025) · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list”
  9. iHerb Singapore — Phosphatidylserine category (default order); first 5 distinct brands in page order: California Gold Nutrition, Doctor's Best, EVLution Nutrition, NOW Foods, Life Extension · read 2026-08-27
    what it says
    “Sunflower Phosphatidylserine, 100 mg, 120 Veggie Capsules … Phosphatidyl Serine, 100 mg, 120 Veggie Caps … Phosphatidyl Serine, 60 Veggie Capsules (150 mg per Capsule) … Phosphatidyl Serine, 120 Veg Capsules … PS Caps, 100 mg, 100 Vegetarian Capsules”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.