Perindopril
Medication
ACE inhibitor
heart & blood pressure
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
SG label: hypertension and stable coronary artery disease
When to take
SG label: once daily in the morning, before a meal
Take with
HealthHub: half to one hour before food
Pros & cons
Pros
- SG label: once-daily dosing, 5 mg or 10 mg
- SG label: no dose change needed in hepatic impairment
- SG label: renal dosing follows a clearance table
Cons
- HealthHub: a dry cough that does not go away is listed
- SG label: contraindicated in 2nd and 3rd trimester
- HealthHub: dizziness on getting up is listed
Sources
- HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (not re-fetched), 27 Aug 2026 · read 2026-08-27
what it says
“COVERSYL 5mg SIN13494P and 10mg SIN13495P (perindopril arginine eqv perindopril 3.395/6.790 mg); HITEN 4 SIN14563P; PERINACE 4MG SIN13602P; PROVINACE 4mg SIN14866P | ATC C09AA04 — all 23 perindopril-containing rows Prescription Only”
- MOH National Drug Formulary (Singapore) — COVERSYL 5MG TABLET [SIN13494P], product information · read 2026-08-27
what it says
“PERINDOPRIL ARGININE 5 MG EQV TO PERINDOPRIL - 3.395 MG … Registration Number SIN13494P … Licence Holder SERVIER (S) PTE LTD … Forensic Classification PRESCRIPTION ONLY MEDICINES … ATC code C09AA04 … Exemptions for Supply without Prescription NA”
- MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.1 Therapeutic indications · read 2026-08-27
what it says
“Coversyl 5 mg and 10 mg — Hypertension: Treatment of hypertension. Stable coronary artery disease: Reduction of risk of cardiac events in patients with a history of myocardial infarction and/or revascularisation”
- MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.2 Method of administration · read 2026-08-27
what it says
“For oral use. COVERSYL is recommended to be taken once daily in the morning before a meal”
- MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.2 Posology: hypertension · read 2026-08-27
what it says
“The recommended starting dose is 5 mg given once daily in the morning … The dose may be increased to 10 mg once daily after one month of treatment”
- MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.2 Posology: symptomatic hypotension with diuretics · read 2026-08-27
what it says
“Symptomatic hypotension may occur following initiation of therapy with COVERSYL; this is more likely in patients who are being treated concurrently with diuretics”
- MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.2 Posology: stable coronary artery disease · read 2026-08-27
what it says
“COVERSYL should be introduced at a dose of 5 mg once daily for two weeks, then increased to 10 mg once daily, depending on renal function and provided that the 5 mg dose is well tolerated”
- MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.2 Posology: symptomatic heart failure · read 2026-08-27
what it says
“a recommended starting dose of 2.5 mg taken in the morning. This dose may be increased after 2 weeks to 5 mg once daily if tolerated. The dose adjustment should be based on the clinical response of the individual patient”
- MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.2 Special population: renal and hepatic impairment · read 2026-08-27
what it says
“Dosage in patients with renal impairment should be based on creatinine clearance as outlined in Table 1 below … No dosage adjustment is necessary in patients with hepatic impairment”
- MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.3 Contraindications · read 2026-08-27
what it says
“History of angioedema associated with previous ACE inhibitor therapy; Hereditary or idiopathic angioedema; Second and third trimesters of pregnancy; Concomitant use of COVERSYL with aliskiren-containing products in patients with diabetes mellitus or renal impairment”
- HealthHub (MOH Singapore) — Perindopril, medication information leaflet · read 2026-08-27
what it says
“Perindopril lowers blood pressure by reducing the production of a substance called Angiotensin II which causes the blood vessels to narrow … Take this medicine half to one hour before food”
- HealthHub (MOH Singapore) — Perindopril, precautions · read 2026-08-27
what it says
“Inform your doctor if you are pregnant or planning to get pregnant … Taking this medication can cause injury and death to your developing fetus. Your doctor may need to monitor your potassium levels and kidney function”
- HealthHub (MOH Singapore) — Perindopril, common side effects · read 2026-08-27
what it says
“The side effects include a dry, annoying cough that does not go away, dizziness and lightheadedness on getting up from a sitting or sleeping position. Very rarely, some patients might experience a loss of taste”
- NHS medicines A–Z — Perindopril, cautions with other medicines · read 2026-08-27
what it says
“anti-inflammatory medicines such as ibuprofen, indomethacin or aspirin for pain relief (low-dose aspirin – 75mg a day, is safe to take with perindopril)”
- NHS medicines A–Z — Perindopril, further cautions with other medicines · read 2026-08-27
what it says
“medicines that make you pee more (diuretics), such as furosemide … medicines that can increase the amount of potassium in your blood, such as spironolactone, triamterene, amiloride, potassium supplements, trimethoprim … or heparin … lithium”
Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.