{"ok":true,"entry":{"slug":"perindopril","kind":"medication","name":"perindopril","aliases":["Coversyl"],"brands_sg":["Coversyl","Hiten","Perinace","Provinace"],"class":"ACE inhibitor","tags":["heart-bp"],"use_for":"sg label: hypertension and stable coronary artery disease","use_after":"sg label: once daily in the morning, before a meal","use_duration":null,"take_with":"healthhub: half to one hour before food","pros":["sg label: once-daily dosing, 5 mg or 10 mg","sg label: no dose change needed in hepatic impairment","sg label: renal dosing follows a clearance table"],"cons":["healthhub: a dry cough that does not go away is listed","sg label: contraindicated in 2nd and 3rd trimester","healthhub: dizziness on getting up is listed"],"dose_note":"the sg coversyl label (sin13494p/sin13495p) tops out at 10 mg once daily and sets it separately per use: in hypertension the recommended starting dose is 5 mg once daily in the morning and \"the dose may be increased to 10 mg once daily after one month of treatment\"; in stable coronary artery disease coversyl \"should be introduced at a dose of 5 mg once daily for two weeks, then increased to 10 mg once daily, depending on renal function\"; in symptomatic heart failure the starting dose is 2.5 mg and \"this dose may be increased after 2 weeks to 5 mg once daily if tolerated\" — as directed on the label or by your doctor","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["pregnant or planning pregnancy — healthhub: taking this medication can cause injury and death to a developing fetus, and the sg label contraindicates the 2nd and 3rd trimesters","a past reaction to any ace inhibitor, or hereditary or idiopathic angioedema — sg label contraindications","kidney function and potassium — healthhub: your doctor may need to monitor potassium levels and kidney function","aliskiren-containing products with diabetes or renal impairment, and sacubitril/valsartan — sg label contraindications"],"clashes":[{"src":["nhs_perindopril_int2"],"note":"nhs lists these among medicines that may affect the way perindopril works","with":"potassium-raising medicines (spironolactone, amiloride, triamterene, potassium supplements, trimethoprim, heparin)"},{"src":["nhs_perindopril_int"],"note":"nhs notes low-dose aspirin at 75 mg a day is safe to take with perindopril","with":"anti-inflammatory painkillers such as ibuprofen or indomethacin"},{"src":["nhs_perindopril_int2","ndf_coversyl_diuretic"],"note":"sg label: symptomatic hypotension is more likely in patients treated concurrently with diuretics","with":"diuretics such as furosemide"},{"src":["ndf_coversyl_ci"],"note":"sg label: concomitant use is contraindicated in patients with diabetes mellitus or renal impairment (gfr < 60)","with":"aliskiren"},{"src":["nhs_perindopril_int2"],"note":"nhs lists lithium among medicines to declare before taking perindopril","with":"lithium"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/api/action/datastore_search?resource_id=d_767279312753558cbf19d48344577084&limit=6000","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (not re-fetched), 27 Aug 2026","quote":"COVERSYL 5mg SIN13494P and 10mg SIN13495P (perindopril arginine eqv perindopril 3.395/6.790 mg); HITEN 4 SIN14563P; PERINACE 4MG SIN13602P; PROVINACE 4mg SIN14866P | ATC C09AA04 — all 23 perindopril-containing rows Prescription Only","accessed":"2026-08-27"},{"id":"ndf_coversyl","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13494p/","label":"MOH National Drug Formulary (Singapore) — COVERSYL 5MG TABLET [SIN13494P], product information","quote":"PERINDOPRIL ARGININE 5 MG EQV TO PERINDOPRIL - 3.395 MG … Registration Number SIN13494P … Licence Holder SERVIER (S) PTE LTD … Forensic Classification PRESCRIPTION ONLY MEDICINES … ATC code C09AA04 … Exemptions for Supply without Prescription NA","accessed":"2026-08-27"},{"id":"ndf_coversyl_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13494p/","label":"MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.1 Therapeutic indications","quote":"Coversyl 5 mg and 10 mg — Hypertension: Treatment of hypertension. Stable coronary artery disease: Reduction of risk of cardiac events in patients with a history of myocardial infarction and/or revascularisation","accessed":"2026-08-27"},{"id":"ndf_coversyl_admin","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13494p/","label":"MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.2 Method of administration","quote":"For oral use. COVERSYL is recommended to be taken once daily in the morning before a meal","accessed":"2026-08-27"},{"id":"ndf_coversyl_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13494p/","label":"MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.2 Posology: hypertension","quote":"The recommended starting dose is 5 mg given once daily in the morning … The dose may be increased to 10 mg once daily after one month of treatment","accessed":"2026-08-27"},{"id":"ndf_coversyl_diuretic","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13494p/","label":"MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.2 Posology: symptomatic hypotension with diuretics","quote":"Symptomatic hypotension may occur following initiation of therapy with COVERSYL; this is more likely in patients who are being treated concurrently with diuretics","accessed":"2026-08-27"},{"id":"ndf_coversyl_dose2","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13494p/","label":"MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.2 Posology: stable coronary artery disease","quote":"COVERSYL should be introduced at a dose of 5 mg once daily for two weeks, then increased to 10 mg once daily, depending on renal function and provided that the 5 mg dose is well tolerated","accessed":"2026-08-27"},{"id":"ndf_coversyl_dose3","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13494p/","label":"MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.2 Posology: symptomatic heart failure","quote":"a recommended starting dose of 2.5 mg taken in the morning. This dose may be increased after 2 weeks to 5 mg once daily if tolerated. The dose adjustment should be based on the clinical response of the individual patient","accessed":"2026-08-27"},{"id":"ndf_coversyl_special","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13494p/","label":"MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.2 Special population: renal and hepatic impairment","quote":"Dosage in patients with renal impairment should be based on creatinine clearance as outlined in Table 1 below … No dosage adjustment is necessary in patients with hepatic impairment","accessed":"2026-08-27"},{"id":"ndf_coversyl_ci","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13494p/","label":"MOH National Drug Formulary (Singapore) — COVERSYL [SIN13494P], 4.3 Contraindications","quote":"History of angioedema associated with previous ACE inhibitor therapy; Hereditary or idiopathic angioedema; Second and third trimesters of pregnancy; Concomitant use of COVERSYL with aliskiren-containing products in patients with diabetes mellitus or renal impairment","accessed":"2026-08-27"},{"id":"healthhub_perindopril","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/perindopril","label":"HealthHub (MOH Singapore) — Perindopril, medication information leaflet","quote":"Perindopril lowers blood pressure by reducing the production of a substance called Angiotensin II which causes the blood vessels to narrow … Take this medicine half to one hour before food","accessed":"2026-08-27"},{"id":"healthhub_perindopril_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/perindopril","label":"HealthHub (MOH Singapore) — Perindopril, precautions","quote":"Inform your doctor if you are pregnant or planning to get pregnant … Taking this medication can cause injury and death to your developing fetus. Your doctor may need to monitor your potassium levels and kidney function","accessed":"2026-08-27"},{"id":"healthhub_perindopril_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/perindopril","label":"HealthHub (MOH Singapore) — Perindopril, common side effects","quote":"The side effects include a dry, annoying cough that does not go away, dizziness and lightheadedness on getting up from a sitting or sleeping position. Very rarely, some patients might experience a loss of taste","accessed":"2026-08-27"},{"id":"nhs_perindopril_int","url":"https://www.nhs.uk/medicines/perindopril/taking-perindopril-with-other-medicines-and-herbal-supplements/","label":"NHS medicines A–Z — Perindopril, cautions with other medicines","quote":"anti-inflammatory medicines such as ibuprofen, indomethacin or aspirin for pain relief (low-dose aspirin – 75mg a day, is safe to take with perindopril)","accessed":"2026-08-27"},{"id":"nhs_perindopril_int2","url":"https://www.nhs.uk/medicines/perindopril/taking-perindopril-with-other-medicines-and-herbal-supplements/","label":"NHS medicines A–Z — Perindopril, further cautions with other medicines","quote":"medicines that make you pee more (diuretics), such as furosemide … medicines that can increase the amount of potassium in your blood, such as spironolactone, triamterene, amiloride, potassium supplements, trimethoprim … or heparin … lithium","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:27.496708+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}