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Perilla seed oil

Supplement fatty acid heart & metabolic
Aka: Perilla frutescens oil, shiso oil
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Another plant omega-3 (ala) oil · small trials only
When to take
Daily
Take with
Absorption runs ~95%, similar to other ingested fats
Studied for
Trials ran 8 weeks to 6 months
Pros & cons
Pros
  • An 8-week 4.8 g/day trial raised plasma ala and EPA
  • Described as a rich dietary source of ala
  • Ala is the only omega-3 the body must get from food
Cons
  • Ala converts to EPA/DHA at under 15%
  • Trials are few, small and short (8 weeks to 6 months)
  • An 8-week trial prolonged adp closure time
Sources
  1. NIH ODS — Omega-3 Fatty Acids (Health Professional) · read 2026-08-27
    what it says
    “The AIs apply only to ALA because ALA is the only omega-3 that is essential. The IOM did not establish specific intake recommendations for EPA, DHA … 19–50 years 1.6 g (male) 1.1 g (female)”
  2. NIH ODS — Omega-3 Fatty Acids (Health Professional) · read 2026-08-27
    what it says
    “ALA can be converted into EPA and then to DHA, but the conversion (which occurs primarily in the liver) is very limited, with reported rates of less than 15%”
  3. NIH ODS — Omega-3 Fatty Acids (Health Professional) · read 2026-08-27
    what it says
    “The IOM did not establish a UL for any omega-3s … FDA has concluded that dietary supplements providing no more than 5 g/day EPA and DHA are safe when used as recommended”
  4. NIH ODS — Omega-3 Fatty Acids (Health Professional) · read 2026-08-27
    what it says
    “The U.S. Food and Drug Administration (FDA) has established a Daily Value (DV) of 65 g for total fat but not for omega-3s”
  5. NIH ODS — Omega-3 Fatty Acids (Health Professional) · read 2026-08-27
    what it says
    “The process is efficient, with an absorption rate of about 95%, which is similar to that of other ingested fats”
  6. NIH ODS — Omega-3 Fatty Acids (Health Professional) · read 2026-08-27
    what it says
    “Fish oil might prolong clotting times, as indicated by an elevated international normalized ratio (INR), when it is taken with warfarin … patients taking these products with anticoagulants should be monitored periodically for changes in INR”
  7. Effects of perilla oil on platelet and inflammatory responses in healthy smokers: a randomized, double-blind, placebo-controlled, parallel trial (Food Funct 2026) · read 2026-08-27
    what it says
    “Perilla oil (PO), a rich dietary source of ALA … 8-week PO supplementation (4.8 g per day) … prolonged collagen-induced ADP-closure time … increased the proportion of ALA in plasma … as well as eicosapentaenoic acid in plasma”
  8. Effects of marine-derived and plant-derived omega-3 PUFAs on erythrocyte fatty acid composition in type 2 diabetic patients (Lipids Health Dis 2022) · read 2026-08-27
    what it says
    “the perilla oil (PO) group was administered with PO at a dose of 3 g/day containing α-linolenic (ALA) … the six-month intervention … A total of 150 patients finished the trial”
  9. HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annex A/B · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.