{"ok":true,"entry":{"slug":"perilla-oil","kind":"supplement","name":"perilla seed oil","aliases":["Perilla frutescens oil","shiso oil"],"brands_sg":[],"class":"fatty acid","tags":["heart"],"use_for":"another plant omega-3 (ala) oil · small trials only","use_after":"daily","use_duration":"trials ran 8 weeks to 6 months","take_with":"absorption runs ~95%, similar to other ingested fats","pros":["an 8-week 4.8 g/day trial raised plasma ala and epa","described as a rich dietary source of ala","ala is the only omega-3 the body must get from food"],"cons":["ala converts to epa/dha at under 15%","trials are few, small and short (8 weeks to 6 months)","an 8-week trial prolonged adp closure time"],"dose_note":"published trials used 4.8 g/day for 8 weeks in healthy smokers and 3 g/day for 6 months in type 2 diabetes; the iom sets an adequate intake for ala, not for perilla oil","dosage":{"ul":null,"unit":"g","fda_dv":null,"rda_ai":"1.6 (men) / 1.1 (women), as ALA","ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["on warfarin or antiplatelets — ask your doctor first","before surgery — a trial prolonged adp closure time"],"clashes":[{"src":["perilla_rct","ods_warfarin"],"note":"a perilla oil trial prolonged collagen-induced adp closure time; omega-3s with anticoagulants warrant inr monitoring","with":"warfarin and other anticoagulants"}],"sources":[{"id":"ods_ai","url":"https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/","label":"NIH ODS — Omega-3 Fatty Acids (Health Professional)","quote":"The AIs apply only to ALA because ALA is the only omega-3 that is essential. The IOM did not establish specific intake recommendations for EPA, DHA … 19–50 years 1.6 g (male) 1.1 g (female)","accessed":"2026-08-27"},{"id":"ods_conv","url":"https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/","label":"NIH ODS — Omega-3 Fatty Acids (Health Professional)","quote":"ALA can be converted into EPA and then to DHA, but the conversion (which occurs primarily in the liver) is very limited, with reported rates of less than 15%","accessed":"2026-08-27"},{"id":"ods_safety","url":"https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/","label":"NIH ODS — Omega-3 Fatty Acids (Health Professional)","quote":"The IOM did not establish a UL for any omega-3s … FDA has concluded that dietary supplements providing no more than 5 g/day EPA and DHA are safe when used as recommended","accessed":"2026-08-27"},{"id":"ods_nodv","url":"https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/","label":"NIH ODS — Omega-3 Fatty Acids (Health Professional)","quote":"The U.S. Food and Drug Administration (FDA) has established a Daily Value (DV) of 65 g for total fat but not for omega-3s","accessed":"2026-08-27"},{"id":"ods_absorb","url":"https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/","label":"NIH ODS — Omega-3 Fatty Acids (Health Professional)","quote":"The process is efficient, with an absorption rate of about 95%, which is similar to that of other ingested fats","accessed":"2026-08-27"},{"id":"ods_warfarin","url":"https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/","label":"NIH ODS — Omega-3 Fatty Acids (Health Professional)","quote":"Fish oil might prolong clotting times, as indicated by an elevated international normalized ratio (INR), when it is taken with warfarin … patients taking these products with anticoagulants should be monitored periodically for changes in INR","accessed":"2026-08-27"},{"id":"perilla_rct","url":"https://europepmc.org/article/MED/42132779","label":"Effects of perilla oil on platelet and inflammatory responses in healthy smokers: a randomized, double-blind, placebo-controlled, parallel trial (Food Funct 2026)","quote":"Perilla oil (PO), a rich dietary source of ALA … 8-week PO supplementation (4.8 g per day) … prolonged collagen-induced ADP-closure time … increased the proportion of ALA in plasma … as well as eicosapentaenoic acid in plasma","accessed":"2026-08-27"},{"id":"perilla_t2dm","url":"https://europepmc.org/article/PMC/PMC8832668","label":"Effects of marine-derived and plant-derived omega-3 PUFAs on erythrocyte fatty acid composition in type 2 diabetic patients (Lipids Health Dis 2022)","quote":"the perilla oil (PO) group was administered with PO at a dose of 3 g/day containing α-linolenic (ALA) … the six-month intervention … A total of 150 patients finished the trial","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annex A/B","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:27.496708+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}