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Panadol extra

Medication paracetamol + caffeine combination pain & fever
Aka: paracetamol 500 mg + caffeine 65 mg, Panadol Extra Optizorb
Brands seen in Singapore: Panadol Extra, Panadol Extra with Optizorb, Panadol Extra Effervescent, Guardian Pain Relief Extra, Watsons Pain Relief Extra
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Stronger pain — bad headache, backache, toothache
When to take
Label: every 4–6 h as required · at least 4 h apart
Take with
With or without food (NHS, on the paracetamol half)
Pros & cons
Pros
  • General sale list in SG — sold beyond pharmacies
  • 500 mg paracetamol plus 65 mg caffeine per caplet
  • Store-brand versions exist at the SAMe 500/65 strength
Cons
  • Other cold/flu products also contain paracetamol
  • Each caplet also carries 65 mg caffeine
  • SG label: 3 days max without asking a doctor
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084, Health Sciences Authority), Forensicclassification column; all 5,511 rows pulled via the datastore_search API on 27 Aug 2026 · read 2026-08-27
    what it says
    “PANADOL EXTRA CAPLET | SIN09110P | General Sale List; PANADOL EXTRA WITH OPTIZORB CAPLETS | SIN14766P | GSL; PANADOL EXTRA EFFERVESCENT | SIN14833P | GSL; GUARDIAN and WATSONS PAIN RELIEF EXTRA CAPLET 500MG/65MG | SIN16261P, SIN16263P | GSL.”
  2. MOH National Drug Formulary (Singapore) — PANADOL EXTRA CAPLET [SIN09110P], paracetamol 500 mg + caffeine 65 mg, Haleon Singapore Pte. Ltd. · read 2026-08-27
    what it says
    “GENERAL SALE LIST … For extra relief from stronger pain, bad headache, backache, joint pain and toothache … Do not take more than 8 caplets in 24 hours … Do not take more than 3 days without asking your doctors”
  3. MOH National Drug Formulary (Singapore) — PANADOL EXTRA WITH OPTIZORB CAPLETS 500mg/65mg [SIN14766P], Haleon Singapore Pte. Ltd. · read 2026-08-27
    what it says
    “Paracetamol 500 mg/caplet … Caffeine 65 mg/caplet … GENERAL SALE LIST … 1–2 caplets taken every 4 to 6 hours as required … Do not exceed the stated dose and do not take more frequently than every 4 hours”
  4. NHS medicines A–Z — Paracetamol for adults (how and when to take it) · read 2026-08-27
    what it says
    “You can take tablets or capsules with or without food … leave at least 4 hours between each dose … do not take more than 8 tablets or capsules in 24 hours”
  5. NHS medicines A–Z — Paracetamol for adults (who it is not suitable for, and medicines that may not mix well) · read 2026-08-27
    what it says
    “avoid taking paracetamol … as other medicines containing paracetamol, for example, cold and flu remedies … medicines to help prevent blood clots, such as warfarin … a kidney or liver condition, you're dependent on alcohol or binge drink”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.