Omega-3 fish oil
Supplement
fatty acid
heart & metabolicbrain & moodbone & joint
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Triglycerides · heart, memory and joint evidence is mixed
When to take
Timing not addressed
Take with
Water · cod liver oil adds vitamin A and d on top of EPA/DHA
Studied for
Trials ran 12–88 months of daily use
Pros & cons
Pros
- Triglycerides down ~15%, dose-dependent, high certainty
- Typical softgel: 1,000 mg oil = 180 mg EPA + 120 mg DHA
- May slightly cut coronary deaths — low certainty
Cons
- Little or no effect on all-cause death or cvd events
- Bad taste/breath, heartburn, nausea, diarrhea
- 4 g/day trials: slightly more atrial fibrillation
Sources
- NIH ODS — Omega-3 Fatty Acids Fact Sheet for Health Professionals — Recommended Intakes (Table 1 AIs for ALA) · read 2026-08-27
what it says
“[ALA AI] 19–50 years: Male 1.6 g, Female 1.1 g, Pregnancy 1.4 g, Lactation 1.3 g … The IOM did not establish specific intake recommendations for EPA, DHA, or other LC omega-3s”
- NIH ODS — Omega-3 Fatty Acids Fact Sheet for Health Professionals — Dietary Supplements (formulations, cod liver oil) · read 2026-08-27
what it says
“several dietary supplement formulations, including fish oil, krill oil, cod liver oil, and vegetarian products that contain algal oil … Cod liver oil supplements provide vitamin A and vitamin D in addition to LC omega-3s”
- NIH ODS — Omega-3 Fatty Acids Fact Sheet for Health Professionals — Dietary Supplements (typical fish oil supplement), Daily Value note · read 2026-08-27
what it says
“A typical fish oil supplement provides about 1,000 mg fish oil, containing 180 mg EPA and 120 mg DHA … has established a Daily Value (DV) of 65 g for total fat but not for omega-3s”
- NIH ODS — Omega-3 Fatty Acids Fact Sheet for Health Professionals — Omega-3s and Health: Cardiovascular disease (AHA guidance, prescription omega-3s) · read 2026-08-27
what it says
“For people with existing coronary heart disease … the AHA recommends approximately 1 g/day EPA plus DHA … 4 g/day prescription omega-3s (containing EPA plus DHA or EPA only) lower triglyceride levels”
- NIH ODS — Omega-3 Fatty Acids Fact Sheet for Health Professionals — Omega-3s and Health: Alzheimer's disease, dementia, and cognitive function · read 2026-08-27
what it says
“For people with mild cognitive impairment, omega-3s may improve certain aspects of cognitive function … LC omega-3 supplementation does not affect cognitive function in healthy older adults or in people with Alzheimer's disease compared to placebo”
- NIH ODS — Omega-3 Fatty Acids Fact Sheet for Health Professionals — Omega-3s and Health: Rheumatoid arthritis · read 2026-08-27
what it says
“Findings to date suggest that LC omega-3s may be helpful as an adjunctive treatment to pharmacotherapy for ameliorating the symptoms of RA”
- NIH ODS — Omega-3 Fatty Acids Fact Sheet for Health Professionals — Health Risks from Excessive Omega-3s (no UL, FDA 5 g/day, side effects) · read 2026-08-27
what it says
“The IOM did not establish a UL for any omega-3s … FDA has concluded that dietary supplements providing no more than 5 g/day EPA and DHA are safe … unpleasant taste, bad breath, heartburn, nausea, gastrointestinal discomfort, diarrhea, headache”
- NIH ODS — Omega-3 Fatty Acids Fact Sheet for Health Professionals — Health Risks from Excessive Omega-3s (atrial fibrillation) · read 2026-08-27
what it says
“taking 4 g/day of omega-3 supplements for several years slightly increased the risk of atrial fibrillation in people with CVD or at high risk of CVD”
- NIH ODS — Omega-3 Fatty Acids Fact Sheet for Health Professionals — Interactions with Medications (anticoagulant and antiplatelet drugs) · read 2026-08-27
what it says
“Fish oil can have antiplatelet effects at high doses, although it appears to be less potent than aspirin … Fish oil might prolong clotting times, as indicated by an elevated international normalized ratio (INR), when it is taken with warfarin”
- Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease (Abdelhamid et al., Cochrane Database Syst Rev 2020, CD003177.pub5) — Main results: trials and doses · read 2026-08-27
what it says
“86 RCTs (162,796 participants) … Trials were of 12 to 88 months' duration … LCn3 doses ranged from 0.5 g a day to more than 5 g a day”
- Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease (Abdelhamid et al., Cochrane Database Syst Rev 2020, CD003177.pub5) — Main results: outcomes · read 2026-08-27
what it says
“little or no effect of increasing LCn3 on all-cause mortality … cardiovascular events … high-certainty evidence … may slightly reduce coronary heart disease mortality … low-certainty evidence … reduced triglycerides by ˜15% in a dose-dependent way (high-certainty evidence)”
- HSA — Health Supplements Guidelines GL-CHPB-3-001 Rev. 020 (January 2026), s3 working definition + clause 4.8 (Tables 4–5 cover vitamins and minerals only) · read 2026-08-27
what it says
“a. Vitamins, minerals, amino acids, fatty acids, enzymes, probiotics and other bioactive substances … 4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5”
- HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. 001 (October 2025), clause 1.3 + Annex A/B · read 2026-08-27
what it says
“to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [fish oil / omega-3 / EPA / DHA not listed in Annex A or B]”
- iHerb Singapore — 'Fish Oil & Omega-3 Supplements | EPA & DHA' category page, default 'Featured' order, 1,066 results · read 2026-08-27
what it says
“California Gold Nutrition, Omega-3 Premium Fish Oil … (1,100 mg per Softgel) … NOW Foods, Omega-3 Fish Oil … Sports Research, Alaskan Omega-3 Fish Oil … Nordic Naturals, Ultimate Omega®, Great Lemon … Life Extension, Super Omega-3”
Updated 2026-08-30. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.