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Olopatadine

Medication ocular/nasal antihistamine allergy
Aka: Patanol, Pataday
Brands seen in Singapore: Patanol, Pataday, Pazeo, Alerchek, Olopan
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
SG label: signs and symptoms of allergic conjunctivitis
When to take
SG label: 1 drop in each affected eye, two times a day
Take with
SG label: other eye drops 5 min apart, ointments last
Pros & cons
Pros
  • Meta-analysis: less redness than ketotifen eye drops
  • Pet study of oral 5 mg: low brain h1 occupancy
  • HSA exemption: pharmacies may supply 0.1% drops, 5 ml
Cons
  • HSA: all 7 SG olopatadine rows are prescription-only
  • Meta-analysis: no edge on itch or tearing vs ketotifen
  • SG label: not for contact lens-related irritation
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (never re-fetched), 7 olopatadine rows, 27 Aug 2026 · read 2026-08-27
    what it says
    “PATANOL 0.1% (SIN10485P), Pataday 0.2% (SIN13961P), PAZEO 0.7% (SIN15242P), ALERCHEK 0.1% and 0.2%, OLOPAN 0.1% and the RYALTRIS nasal spray (olopatadine with mometasone) all read "Prescription Only"”
  2. MOH National Drug Formulary — PATANOL STERILE OPHTHALMIC SOLUTION 0.1% [SIN10485P], Product information block · read 2026-08-27
    what it says
    “OLOPATADINE HCL 11.1 MG/ML EQV OLOPATADINE - 1 MG/ML … Forensic Classification: PRESCRIPTION ONLY MEDICINES · Anatomical Therapeutic Chemical (ATC) code S01GX09”
  3. MOH National Drug Formulary — PATANOL [SIN10485P], Prescription-only Medicines with Exemptions for Supply without Prescription · read 2026-08-27
    what it says
    “As an eyedrop not exceeding 0.2%. Indication: Short-term treatment of symptoms of allergic conjunctivitis. Maximum daily dose: 0.1%: One drop in each affected eye two times per day. Maximum supply: 0.1%: 5ml. Minimum age: 3 years”
  4. MOH National Drug Formulary — PATANOL [SIN10485P], Therapeutic indications · read 2026-08-27
    what it says
    “PATANOL eye drops is indicated for the treatment of the signs and symptoms of allergic conjunctivitis.”
  5. MOH National Drug Formulary — PATANOL [SIN10485P], Posology and method of administration · read 2026-08-27
    what it says
    “The recommended dose is 1 drop in each affected eye 2 times per day … the products must be administered at least 5 minutes apart. Eye ointments should be administered last.”
  6. MOH National Drug Formulary — PATANOL [SIN10485P], Contraindications and paediatric use · read 2026-08-27
    what it says
    “Hypersensitivity to the active substance or to any of the excipients … Safety and effectiveness in paediatric patients below the age of 3 years have not been established … Patanol should not be used to treat contact lens related irritation.”
  7. US FDA OTC Drug Facts (DailyMed/openFDA) — PATADAY TWICE A DAY RELIEF, olopatadine 0.1% eye drops · read 2026-08-27
    what it says
    “Olopatadine (0.1%) … Antihistamine and Redness Reliever … adults and children 2 years of age and older: put 1 drop in the affected eye(s) twice daily, every 6 to 8 hours, no more than twice per day”
  8. US FDA OTC Drug Facts (DailyMed/openFDA) — PATADAY ONCE DAILY RELIEF, olopatadine 0.2% eye drops · read 2026-08-27
    what it says
    “adults and children 2 years of age and older: put 1 drop in the affected eye(s) once daily, no more than once per day … temporarily relieves itchy eyes due to pollen, ragweed, grass, animal hair and dander”
  9. Comparison of olopatadine with ketotifen for allergic conjunctivitis: a meta-analysis (Li S, Zhong S; Postepy Dermatol Alergol 2023; 7 RCTs) · read 2026-08-27
    what it says
    “compared with ketotifen intervention for allergic conjunctivitis, olopatadine intervention was associated with substantially lower hyperaemia … but demonstrated no significant impact on itching, tearing or papillae”
  10. Brain histamine H1 receptor occupancy of orally administered antihistamines measured by PET: a comparison of olopatadine and ketotifen (Tashiro et al., Br J Clin Pharmacol 2006) · read 2026-08-27
    what it says
    “H(1)R occupancy after olopatadine treatment was significantly lower than that after ketotifen treatment in the all cortical regions … 5 mg oral olopatadine, with its low H(1)R occupancy and thus minimal sedation”
  11. NHS — Antihistamines (conditions A–Z), types and forms · read 2026-08-27
    what it says
    “Antihistamines block the effects of a substance called histamine in your body … They also come in several different forms – including tablets, capsules, liquids, syrups, creams, lotions, gels, eyedrops and nasal sprays.”
  12. NHS — Antihistamines: who can take antihistamines · read 2026-08-27
    what it says
    “speak to a pharmacist or GP for advice if you: are pregnant or breastfeeding … are an older person … have an underlying health condition, such as heart disease, liver disease, kidney disease or epilepsy”
  13. NHS — Antihistamines: taking antihistamines with other medicines, food or alcohol · read 2026-08-27
    what it says
    “Examples of medicines that could cause problems if taken with antihistamines include some types of: antidepressants; stomach ulcer or indigestion medicines; cough and cold remedies that also contain an antihistamine”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.