{"ok":true,"entry":{"slug":"olopatadine","kind":"medication","name":"olopatadine","aliases":["Patanol","Pataday"],"brands_sg":["Patanol","Pataday","Pazeo","Alerchek","Olopan"],"class":"ocular/nasal antihistamine","tags":["allergy"],"use_for":"sg label: signs and symptoms of allergic conjunctivitis","use_after":"sg label: 1 drop in each affected eye, two times a day","use_duration":null,"take_with":"sg label: other eye drops 5 min apart, ointments last","pros":["meta-analysis: less redness than ketotifen eye drops","pet study of oral 5 mg: low brain h1 occupancy","hsa exemption: pharmacies may supply 0.1% drops, 5 ml"],"cons":["hsa: all 7 sg olopatadine rows are prescription-only","meta-analysis: no edge on itch or tearing vs ketotifen","sg label: not for contact lens-related irritation"],"dose_note":"the singapore label maximum, from the moh national drug formulary page for PATANOL STERILE OPHTHALMIC SOLUTION 0.1% [SIN10485P], is \"The recommended dose is 1 drop in each affected eye 2 times per day\", with safety below 3 years not established. the same page's supply-without-prescription exemption block reads \"As an eyedrop not exceeding 0.2% — Maximum daily dose: 0.1%: One drop in each affected eye two times per day — Maximum supply: 0.1%: 5ml — Minimum age: 3 years\". the us otc drug facts labels for the same molecule cap it by strength: Pataday Twice a Day Relief 0.1% at \"1 drop in the affected eye(s) twice daily, every 6 to 8 hours, no more than twice per day\" and Pataday Once Daily Relief 0.2% at \"1 drop in the affected eye(s) once daily, no more than once per day\". in singapore the prescriber or pharmacist sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["under 3 years — the sg label says safety is not established","contact lens-related eye irritation — the sg label says it is not for that","hypersensitivity to olopatadine or the excipients — an sg label contraindication","pregnancy or breastfeeding — nhs: pharmacist or gp advice first for any antihistamine"],"clashes":[{"src":["ndf_patanol_dose"],"note":"sg label: products must be given at least 5 minutes apart, and eye ointments last","with":"other topical eye products"},{"src":["nhs_anti_mix"],"note":"nhs flags doubling up on antihistamine through an all-in-one remedy","with":"cough and cold remedies containing an antihistamine"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (never re-fetched), 7 olopatadine rows, 27 Aug 2026","quote":"PATANOL 0.1% (SIN10485P), Pataday 0.2% (SIN13961P), PAZEO 0.7% (SIN15242P), ALERCHEK 0.1% and 0.2%, OLOPAN 0.1% and the RYALTRIS nasal spray (olopatadine with mometasone) all read \"Prescription Only\"","accessed":"2026-08-27"},{"id":"ndf_patanol_class","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin10485p/","label":"MOH National Drug Formulary — PATANOL STERILE OPHTHALMIC SOLUTION 0.1% [SIN10485P], Product information block","quote":"OLOPATADINE HCL 11.1 MG/ML EQV OLOPATADINE - 1 MG/ML … Forensic Classification: PRESCRIPTION ONLY MEDICINES · Anatomical Therapeutic Chemical (ATC) code S01GX09","accessed":"2026-08-27"},{"id":"ndf_patanol_exempt","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin10485p/","label":"MOH National Drug Formulary — PATANOL [SIN10485P], Prescription-only Medicines with Exemptions for Supply without Prescription","quote":"As an eyedrop not exceeding 0.2%. Indication: Short-term treatment of symptoms of allergic conjunctivitis. Maximum daily dose: 0.1%: One drop in each affected eye two times per day. Maximum supply: 0.1%: 5ml. Minimum age: 3 years","accessed":"2026-08-27"},{"id":"ndf_patanol_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin10485p/","label":"MOH National Drug Formulary — PATANOL [SIN10485P], Therapeutic indications","quote":"PATANOL eye drops is indicated for the treatment of the signs and symptoms of allergic conjunctivitis.","accessed":"2026-08-27"},{"id":"ndf_patanol_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin10485p/","label":"MOH National Drug Formulary — PATANOL [SIN10485P], Posology and method of administration","quote":"The recommended dose is 1 drop in each affected eye 2 times per day … the products must be administered at least 5 minutes apart. Eye ointments should be administered last.","accessed":"2026-08-27"},{"id":"ndf_patanol_contra","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin10485p/","label":"MOH National Drug Formulary — PATANOL [SIN10485P], Contraindications and paediatric use","quote":"Hypersensitivity to the active substance or to any of the excipients … Safety and effectiveness in paediatric patients below the age of 3 years have not been established … Patanol should not be used to treat contact lens related irritation.","accessed":"2026-08-27"},{"id":"fda_pataday_2x","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b7a24375-25df-4405-aa7c-34c46af51194","label":"US FDA OTC Drug Facts (DailyMed/openFDA) — PATADAY TWICE A DAY RELIEF, olopatadine 0.1% eye drops","quote":"Olopatadine (0.1%) … Antihistamine and Redness Reliever … adults and children 2 years of age and older: put 1 drop in the affected eye(s) twice daily, every 6 to 8 hours, no more than twice per day","accessed":"2026-08-27"},{"id":"fda_pataday_1x","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1c7d2342-ba1c-4244-9814-d92a05725d4e","label":"US FDA OTC Drug Facts (DailyMed/openFDA) — PATADAY ONCE DAILY RELIEF, olopatadine 0.2% eye drops","quote":"adults and children 2 years of age and older: put 1 drop in the affected eye(s) once daily, no more than once per day … temporarily relieves itchy eyes due to pollen, ragweed, grass, animal hair and dander","accessed":"2026-08-27"},{"id":"li2023","url":"https://europepmc.org/article/PMC/PMC10258714","label":"Comparison of olopatadine with ketotifen for allergic conjunctivitis: a meta-analysis (Li S, Zhong S; Postepy Dermatol Alergol 2023; 7 RCTs)","quote":"compared with ketotifen intervention for allergic conjunctivitis, olopatadine intervention was associated with substantially lower hyperaemia … but demonstrated no significant impact on itching, tearing or papillae","accessed":"2026-08-27"},{"id":"tashiro2006","url":"https://europepmc.org/article/PMC/PMC1884984","label":"Brain histamine H1 receptor occupancy of orally administered antihistamines measured by PET: a comparison of olopatadine and ketotifen (Tashiro et al., Br J Clin Pharmacol 2006)","quote":"H(1)R occupancy after olopatadine treatment was significantly lower than that after ketotifen treatment in the all cortical regions … 5 mg oral olopatadine, with its low H(1)R occupancy and thus minimal sedation","accessed":"2026-08-27"},{"id":"nhs_anti_types","url":"https://www.nhs.uk/conditions/antihistamines/","label":"NHS — Antihistamines (conditions A–Z), types and forms","quote":"Antihistamines block the effects of a substance called histamine in your body … They also come in several different forms – including tablets, capsules, liquids, syrups, creams, lotions, gels, eyedrops and nasal sprays.","accessed":"2026-08-27"},{"id":"nhs_anti_who","url":"https://www.nhs.uk/conditions/antihistamines/","label":"NHS — Antihistamines: who can take antihistamines","quote":"speak to a pharmacist or GP for advice if you: are pregnant or breastfeeding … are an older person … have an underlying health condition, such as heart disease, liver disease, kidney disease or epilepsy","accessed":"2026-08-27"},{"id":"nhs_anti_mix","url":"https://www.nhs.uk/conditions/antihistamines/","label":"NHS — Antihistamines: taking antihistamines with other medicines, food or alcohol","quote":"Examples of medicines that could cause problems if taken with antihistamines include some types of: antidepressants; stomach ulcer or indigestion medicines; cough and cold remedies that also contain an antihistamine","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:27.496708+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}