Nebivolol

“NEBILET TABLET 5 mg SIN11728P · NEVODIO TABLET 5MG SIN16446P · NEVOPRES TABLET 5MG SIN15958P · NOXBETA TABLET 5 MG SIN16486P · NEBIPRESS TABLETS 5MG SIN16976P — all 7 rows 5 mg, ATC C07AB12, “Prescription Only””

“Nebivolol belongs to a group of medications known as beta-blockers. Beta-blockers are usually used in the treatment of different conditions such as High blood pressure; Irregular heartbeat; Reduce chest pain/ discomfort (Angina); Heart failure”

“You may take this medication with or without food … do not stop this medication suddenly without consulting your healthcare professional. Stopping your medication suddenly may worsen your condition.”

“You have asthma or other breathing problems – this medication may worsen or cause an asthma attack. You have pre-diabetes or diabetes - this medication may hide symptoms of low blood sugar such as fast heartbeat or tremors.”

“Dizziness and lightheadedness … Coldness, numbness or tingling sensation of your fingers or toes; Feeling weak and tired, and that your heart beats slower; Shortness of breath; Problems with sexual intercourse”

“The dose is one tablet (5 mg) daily, preferably at the same time of the day. The blood pressure lowering effect becomes evident after 1–2 weeks of treatment. Occasionally, the optimal effect is reached only after 4 weeks.”

“1.25 mg nebivolol, to be increased to 2.5 mg nebivolol once daily, then to 5 mg once daily and then to 10 mg once daily. The maximum recommended dose is 10 mg nebivolol once daily.”

“Beta-blockers can be used alone or concomitantly with other antihypertensive agents. Till date, an additional antihypertensive effect has been observed only when Nebilet 5 mg is combined with hydrochlorothiazide 12.5–25 mg.”

“Liver insufficiency or liver function impairment. Pregnancy and lactation … sick sinus syndrome … second and third degree heart block (without a pacemaker). history of bronchospasm and bronchial asthma … bradycardia (heart rate < 60 bpm prior to start therapy)”

“Use caution when nebivolol is co-administered with CYP2D6 inhibitors (quinidine, propafenone, fluoxetine, paroxetine, etc.) … Do not use nebivolol tablets with other β-blockers … Verapamil- or diltiazem-type calcium channel blockers may cause excessive reductions in heart rate”

“For most patients, the recommended starting dose is 5 mg once daily … For patients requiring further reduction in blood pressure, the dose can be increased at 2-week intervals up to 40 mg.”

“Do not abruptly discontinue nebivolol therapy in patients with coronary artery disease. Severe exacerbation of angina, myocardial infarction and ventricular arrhythmias have been reported … following the abrupt discontinuation of therapy with β-blockers.”