{"ok":true,"entry":{"slug":"nebivolol","kind":"medication","name":"nebivolol","aliases":["Nebilet"],"brands_sg":["Nebilet","Nevodio","Nevopres","Noxbeta","Nebipress"],"class":"beta blocker","tags":["heart-bp"],"use_for":"healthhub: high blood pressure, angina, heart failure","use_after":"sg label: one 5 mg tablet daily, same time each day","use_duration":null,"take_with":"healthhub: with or without food","pros":["sg label: bp effect shows after 1–2 weeks","healthhub: a once-a-day tablet","sg label: pairs with hydrochlorothiazide 12.5–25 mg"],"cons":["healthhub: dizziness, cold fingers, tiredness","healthhub: it can hide low-blood-sugar warning signs","us label: stopping abruptly can worsen angina"],"dose_note":"the singapore product information for nebilet (national drug formulary) gives, for hypertension in adults, “The dose is one tablet (5 mg) daily, preferably at the same time of the day”, and for chronic heart failure a stepped uptitration “1.25 mg nebivolol, to be increased to 2.5 mg nebivolol once daily, then to 5 mg once daily and then to 10 mg once daily. The maximum recommended dose is 10 mg nebivolol once daily.” — 10 mg a day is the ceiling on that sg insert, and every nebivolol product registered in singapore is a 5 mg tablet. starting doses are lower (2.5 mg daily) in renal impairment and over-65s on the same label.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["asthma or other breathing problems — healthhub: it may worsen or cause an asthma attack","pre-diabetes or diabetes — healthhub: it may hide low-blood-sugar symptoms","liver insufficiency, pregnancy or breastfeeding — sg label contraindications","slow pulse under 60 bpm, low blood pressure or heart block — sg label contraindications"],"clashes":[{"src":["fda_neb_di"],"note":"us label: nebivolol tablets are not used with other beta-blockers","with":"other beta blockers"},{"src":["fda_neb_di"],"note":"us label: may cause excessive reductions in heart rate, blood pressure and contractility","with":"verapamil- or diltiazem-type calcium channel blockers"},{"src":["fda_neb_di"],"note":"us label: caution — these may increase nebivolol levels","with":"cyp2d6 inhibitors such as fluoxetine, paroxetine, quinidine"},{"src":["fda_neb_di"],"note":"us label: both slow av conduction, so bradycardia risk rises","with":"digitalis glycosides (digoxin)"},{"src":["fda_neb_di"],"note":"us label: excessive reduction of sympathetic activity; clonidine tapering is sequenced","with":"clonidine or reserpine"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg d_767279312753558cbf19d48344577084); cached at /tmp/hsa_all.json and filtered locally (not re-fetched), 7 nebivolol rows","quote":"NEBILET TABLET 5 mg SIN11728P · NEVODIO TABLET 5MG SIN16446P · NEVOPRES TABLET 5MG SIN15958P · NOXBETA TABLET 5 MG SIN16486P · NEBIPRESS TABLETS 5MG SIN16976P — all 7 rows 5 mg, ATC C07AB12, “Prescription Only”","accessed":"2026-08-27"},{"id":"hh_neb_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/nebivolol","label":"HealthHub (Pharmaceutical Society of Singapore / MOH) — Nebivolol: what is this medication for","quote":"Nebivolol belongs to a group of medications known as beta-blockers. Beta-blockers are usually used in the treatment of different conditions such as High blood pressure; Irregular heartbeat; Reduce chest pain/ discomfort (Angina); Heart failure","accessed":"2026-08-27"},{"id":"hh_neb_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/nebivolol","label":"HealthHub — Nebivolol: how should I take or use this medication","quote":"You may take this medication with or without food … do not stop this medication suddenly without consulting your healthcare professional. Stopping your medication suddenly may worsen your condition.","accessed":"2026-08-27"},{"id":"hh_neb_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/nebivolol","label":"HealthHub — Nebivolol: what precautions should I take","quote":"You have asthma or other breathing problems – this medication may worsen or cause an asthma attack. You have pre-diabetes or diabetes - this medication may hide symptoms of low blood sugar such as fast heartbeat or tremors.","accessed":"2026-08-27"},{"id":"hh_neb_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/nebivolol","label":"HealthHub — Nebivolol: common side effects","quote":"Dizziness and lightheadedness … Coldness, numbness or tingling sensation of your fingers or toes; Feeling weak and tired, and that your heart beats slower; Shortness of breath; Problems with sexual intercourse","accessed":"2026-08-27"},{"id":"ndf_neb_htn","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11728p/","label":"Singapore National Drug Formulary — NEBILET TABLET 5 mg [SIN11728P], Posology (hypertension)","quote":"The dose is one tablet (5 mg) daily, preferably at the same time of the day. The blood pressure lowering effect becomes evident after 1–2 weeks of treatment. Occasionally, the optimal effect is reached only after 4 weeks.","accessed":"2026-08-27"},{"id":"ndf_neb_chf","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11728p/","label":"Singapore National Drug Formulary — NEBILET [SIN11728P], Posology (chronic heart failure uptitration)","quote":"1.25 mg nebivolol, to be increased to 2.5 mg nebivolol once daily, then to 5 mg once daily and then to 10 mg once daily. The maximum recommended dose is 10 mg nebivolol once daily.","accessed":"2026-08-27"},{"id":"ndf_neb_combo","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11728p/","label":"Singapore National Drug Formulary — NEBILET [SIN11728P], combination with other antihypertensives","quote":"Beta-blockers can be used alone or concomitantly with other antihypertensive agents. Till date, an additional antihypertensive effect has been observed only when Nebilet 5 mg is combined with hydrochlorothiazide 12.5–25 mg.","accessed":"2026-08-27"},{"id":"ndf_neb_contra","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11728p/","label":"Singapore National Drug Formulary — NEBILET [SIN11728P], Contraindications","quote":"Liver insufficiency or liver function impairment. Pregnancy and lactation … sick sinus syndrome … second and third degree heart block (without a pacemaker). history of bronchospasm and bronchial asthma … bradycardia (heart rate < 60 bpm prior to start therapy)","accessed":"2026-08-27"},{"id":"fda_neb_di","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22nebivolol%22&limit=3","label":"US label for nebivolol tablets (effective 2024-10-31) via openFDA drug/label.json, Drug Interactions","quote":"Use caution when nebivolol is co-administered with CYP2D6 inhibitors (quinidine, propafenone, fluoxetine, paroxetine, etc.) … Do not use nebivolol tablets with other β-blockers … Verapamil- or diltiazem-type calcium channel blockers may cause excessive reductions in heart rate","accessed":"2026-08-27"},{"id":"fda_neb_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22nebivolol%22&limit=3","label":"US label for nebivolol tablets via openFDA drug/label.json, Dosage and Administration (hypertension)","quote":"For most patients, the recommended starting dose is 5 mg once daily … For patients requiring further reduction in blood pressure, the dose can be increased at 2-week intervals up to 40 mg.","accessed":"2026-08-27"},{"id":"fda_neb_warn","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22nebivolol%22&limit=3","label":"US label for nebivolol tablets via openFDA drug/label.json, Warnings and Precautions","quote":"Do not abruptly discontinue nebivolol therapy in patients with coronary artery disease. Severe exacerbation of angina, myocardial infarction and ventricular arrhythmias have been reported … following the abrupt discontinuation of therapy with β-blockers.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:26.600885+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}