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Muira puama

Supplement botanical men's health
Aka: Ptychopetalum olacoides, potency wood
Brands seen in Singapore: Swanson Vitamins, Solaray, Vitacost, Nutricost, Nature's Answer
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Amazonian aphrodisiac tradition — graded no effect for ed
Pros & cons
Pros
  • Long amazonian use for libido and as a nerve tonic
  • No human psychiatric or neurological reports found
Cons
  • Not among the 8 ed ingredients with RCT evidence
  • Rodent studies show memory and locomotion effects
  • SG bars sexual-dysfunction claims (table 6)
Sources
  1. Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects (Cinquina et al., Pharmaceuticals 2020), section 3.7 Ptychopetalum olacoides · read 2026-08-27
    what it says
    “Ptychopetalum olacoides Benth. is a popular Amazonian tree … The native communities have used its roots and barks as a treatment for depression, sexual dysfunction, and as a “nerve tonic””
  2. Cinquina et al., Pharmaceuticals 2020 — reported adverse effects for Ptychopetalum olacoides · read 2026-08-27
    what it says
    “A few neurological side effects were reported in preclinical studies, including impairment of both short- and long-term memory and reduced locomotion”
  3. Cinquina et al., Pharmaceuticals 2020 — abstract, overall safety conclusion across the reviewed sexual enhancers · read 2026-08-27
    what it says
    “Most of the selected sexual enhancers appeared to be safe at therapeutic doses, although mild to severe adverse effects may occur in cases of overdosing or self-medication with unstandardized products.”
  4. Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational Use (Barbonetti et al., Nutrients 2023) — results · read 2026-08-27
    what it says
    “A total of 41 different active ingredients were used by manufacturers … Based on the literature analysis, we found that 33 out of the 41 ingredients had no reported efficacy on ED.”
  5. Barbonetti et al., Nutrients 2023 — evidence-grading scale adapted from the American Heart Association system · read 2026-08-27
    what it says
    “An ingredient was designated evidence level A if it demonstrated a net positive impact in multiple RCTs … level D was given for ingredients showing negative or no effect on the analyzed outcomes.”
  6. Barbonetti et al., Nutrients 2023 — the eight ingredients with recognised clinical evidence of efficacy (muira puama and Turnera diffusa are not among them) · read 2026-08-27
    what it says
    “six EIs with evidence of efficacy were supported by at least two RCTs, namely, Eurycoma longifolia, Panax ginseng, L-arginine, Corynanthe yohimbe, Tribulus terrestris and Pinus pinaster. The remaining two EIs, namely, Crocus sativus and Withania somnifera”
  7. Barbonetti et al., Nutrients 2023 — Table 1, amounts of muira puama in the marketed supplements analysed, with their evidence grade · read 2026-08-27
    what it says
    “Muira puama 100 mg D 100 mg D 100 mg D 600 mg D”
  8. HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (October 2025), Annex A (118 rows) and Annex B (4 rows) — muira puama / Ptychopetalum olacoides is NOT LISTED in either annex; Annex A runs 71. Mucuna then 72. N-acetyl cysteine, and 86. Psilocybe cubensis then 87. Punica granatum, where 'Muira' and 'Ptychopetalum' rows would fall · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  9. HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 with Tables 4–5 (vitamins and minerals only — no botanical rows) · read 2026-08-27
    what it says
    “4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.”
  10. HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 6.6 and Table 6 (diseases/conditions not allowed for health supplements), reproductive-system row · read 2026-08-27
    what it says
    “HS must not be labelled, advertised or promoted for any specific medicinal purpose … Reproductive system: Menstrual disorders, sexual dysfunction, infertility, frigidity, impotency, conception, pregnancy”
  11. iHerb Singapore — Muira Puama category page, default listing order · read 2026-08-27
    what it says
    “1 - 7 of 7 results: Swanson Vitamins, Full Spectrum Muira Puama 400 mg; Swanson Vitamins, Muira Puama 250 mg; Solaray, True Herbs Muira Puama; Vitacost, Everyday Muira Puama; Nutricost, Muira Puama; Nature's Answer, Muira Puama”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.