{"ok":true,"entry":{"slug":"muira-puama","kind":"supplement","name":"muira puama","aliases":["Ptychopetalum olacoides","potency wood"],"brands_sg":["Swanson Vitamins","Solaray","Vitacost","Nutricost","Nature's Answer"],"class":"botanical","tags":["mens-health"],"use_for":"amazonian aphrodisiac tradition — graded no effect for ed","use_after":null,"use_duration":null,"take_with":null,"pros":["long amazonian use for libido and as a nerve tonic","no human psychiatric or neurological reports found"],"cons":["not among the 8 ed ingredients with rct evidence","rodent studies show memory and locomotion effects","sg bars sexual-dysfunction claims (table 6)"],"dose_note":"a 2023 systematic review of erectile-dysfunction supplements sold in italy found muira puama in commercial formulations at 100 mg to 600 mg a day and scored it level D, the grade the review gives ingredients showing negative or no effect on the analysed outcomes; 33 of the 41 ingredients it catalogued had no reported efficacy on ed, and muira puama is not among the eight that did; no rda, ul, fda daily value or hsa singapore daily limit exists for muira puama","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["preclinical studies reported impaired short- and long-term memory and reduced locomotion","the 2020 review notes adverse effects can appear with overdosing or unstandardised products","not listed in hsa's prohibited or restricted annexes — that is absence of a listing, not a safety finding"],"clashes":[],"sources":[{"id":"enhancers2020_muira","url":"https://europepmc.org/article/PMC/PMC7602496","label":"Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects (Cinquina et al., Pharmaceuticals 2020), section 3.7 Ptychopetalum olacoides","quote":"Ptychopetalum olacoides Benth. is a popular Amazonian tree … The native communities have used its roots and barks as a treatment for depression, sexual dysfunction, and as a “nerve tonic”","accessed":"2026-08-27"},{"id":"enhancers2020_muira_ae","url":"https://europepmc.org/article/PMC/PMC7602496","label":"Cinquina et al., Pharmaceuticals 2020 — reported adverse effects for Ptychopetalum olacoides","quote":"A few neurological side effects were reported in preclinical studies, including impairment of both short- and long-term memory and reduced locomotion","accessed":"2026-08-27"},{"id":"enhancers2020_overall","url":"https://europepmc.org/article/PMC/PMC7602496","label":"Cinquina et al., Pharmaceuticals 2020 — abstract, overall safety conclusion across the reviewed sexual enhancers","quote":"Most of the selected sexual enhancers appeared to be safe at therapeutic doses, although mild to severe adverse effects may occur in cases of overdosing or self-medication with unstandardized products.","accessed":"2026-08-27"},{"id":"ed_review2023_noeff","url":"https://europepmc.org/article/PMC/PMC10490034","label":"Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational Use (Barbonetti et al., Nutrients 2023) — results","quote":"A total of 41 different active ingredients were used by manufacturers … Based on the literature analysis, we found that 33 out of the 41 ingredients had no reported efficacy on ED.","accessed":"2026-08-27"},{"id":"ed_review2023_grades","url":"https://europepmc.org/article/PMC/PMC10490034","label":"Barbonetti et al., Nutrients 2023 — evidence-grading scale adapted from the American Heart Association system","quote":"An ingredient was designated evidence level A if it demonstrated a net positive impact in multiple RCTs … level D was given for ingredients showing negative or no effect on the analyzed outcomes.","accessed":"2026-08-27"},{"id":"ed_review2023_eight","url":"https://europepmc.org/article/PMC/PMC10490034","label":"Barbonetti et al., Nutrients 2023 — the eight ingredients with recognised clinical evidence of efficacy (muira puama and Turnera diffusa are not among them)","quote":"six EIs with evidence of efficacy were supported by at least two RCTs, namely, Eurycoma longifolia, Panax ginseng, L-arginine, Corynanthe yohimbe, Tribulus terrestris and Pinus pinaster. The remaining two EIs, namely, Crocus sativus and Withania somnifera","accessed":"2026-08-27"},{"id":"ed_review2023_dose","url":"https://europepmc.org/article/PMC/PMC10490034","label":"Barbonetti et al., Nutrients 2023 — Table 1, amounts of muira puama in the marketed supplements analysed, with their evidence grade","quote":"Muira puama 100 mg D 100 mg D 100 mg D 600 mg D","accessed":"2026-08-27"},{"id":"hsa_prohibited","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (October 2025), Annex A (118 rows) and Annex B (4 rows) — muira puama / Ptychopetalum olacoides is NOT LISTED in either annex; Annex A runs 71. Mucuna then 72. N-acetyl cysteine, and 86. Psilocybe cubensis then 87. Punica granatum, where 'Muira' and 'Ptychopetalum' rows would fall","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs_guidelines","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 with Tables 4–5 (vitamins and minerals only — no botanical rows)","quote":"4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"hsa_claims_table6","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 6.6 and Table 6 (diseases/conditions not allowed for health supplements), reproductive-system row","quote":"HS must not be labelled, advertised or promoted for any specific medicinal purpose … Reproductive system: Menstrual disorders, sexual dysfunction, infertility, frigidity, impotency, conception, pregnancy","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/muira-puama","label":"iHerb Singapore — Muira Puama category page, default listing order","quote":"1 - 7 of 7 results: Swanson Vitamins, Full Spectrum Muira Puama 400 mg; Swanson Vitamins, Muira Puama 250 mg; Solaray, True Herbs Muira Puama; Vitacost, Everyday Muira Puama; Nutricost, Muira Puama; Nature's Answer, Muira Puama","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:26.600885+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}